Home Cart 0 Sign in  

[ CAS No. 255060-77-6 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 255060-77-6
Chemical Structure| 255060-77-6
Structure of 255060-77-6 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 255060-77-6 ]

Related Doc. of [ 255060-77-6 ]

Alternatived Products of [ 255060-77-6 ]

Product Details of [ 255060-77-6 ]

CAS No. :255060-77-6 MDL No. :MFCD08436134
Formula : C13H20N2O2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 236.31 Pubchem ID :-
Synonyms :

Safety of [ 255060-77-6 ]

Signal Word:Warning Class:
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:
Hazard Statements:H302-H315-H319-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 255060-77-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 255060-77-6 ]

[ 255060-77-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 58757-38-3 ]
  • [ 255060-77-6 ]
  • [ 1039736-62-3 ]
YieldReaction ConditionsOperation in experiment
86% With triethylamine In dichloromethane at 20℃; 269.3 To a solution of (S)-tert-butyl 1 -(4-aminophenyl)ethylcarbamate (440 mg,1.86 mmol) in dichloromethane (7.0 mL) and triethylamine (excess) was added 6- chloronicotinoyl chloride (380 mg, 2.2 mmol) and the reaction stirred at room temperature overnight. White precipitate formed and was collected by filtration, the solids washed with dichloromethane and dried in a vacuum oven to yield (S)-tert-butyl l-(4-(6- chloronicotinamido)phenyl)ethylcarbamate (600 mg; 86%; (M+H)-376.1).
  • 2
  • [ 24424-99-5 ]
  • [ 57233-86-0 ]
  • [ 255060-77-6 ]
  • 3
  • [ 56651-60-6 ]
  • [ 255060-77-6 ]
  • tert-butyl (S)-(1-(4-(3-(4-methoxybenzyl)ureido)phenyl)ethyl)carbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
28% In dichloromethane at 20℃; for 4h; B.1 Step 1: Preparation of tert-butyl (S)-(1-(4-(3-(4-methoxybenzyl)ureido)phenyl)-ethyl)carbamate (Intermediate 2-a): [0206] To a solution of (S)-[1-(4-amino-phenyl)-ethyl]-carbamic acid tert- butyl ester (2.0 g, 22.7 mmol) in DCM (20 mL) at 20 C was added 4-methoxy benzyl isocyanate (14.4 g, 34.0 mmol) dropwise. The resulting mixture was stirred at room temperature for 4 hours then methanol (10 mL) was added and cooled to 0°C. After 1Hour at 0°C the slurry was filtered providing the tert-butyl (S)-(1-(4-(3-(4-methoxybenzyl)ureido)-phenyl)ethyl)carbamate (1.2 g, 6.3 mmol, 28% yield) as an off-white solid. LCMS-APCI (POS.) m/z: 400.1 (M+H)+. 1H NMR (400 MHz, DMS04) d 8.43 (s,1H), 7.36 - 7.19 (m, 4H), 7.14 (d, J= 8.2 Hz, 2H), 6.89 (d, J= 8.2 Hz, 2H), 6.48 (t, J= 5.9 Hz,1H), 4.53 (p, J= 7.3 Hz,1H), 4.21 (d, J= 5.7 Hz, 2H), 3.73 (s, 3H),1.37 (s, 9H),1.27 (d, J= 7.0 Hz, 3H).
Same Skeleton Products
Historical Records