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Chemical Structure| 256473-81-1 Chemical Structure| 256473-81-1

Structure of 256473-81-1

Chemical Structure| 256473-81-1

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Product Details of [ 256473-81-1 ]

CAS No. :256473-81-1
Formula : C6H5NO4
M.W : 155.11
SMILES Code : O=C(C1=C(C=O)C(C)=NO1)O
MDL No. :MFCD18821844

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Application In Synthesis of [ 256473-81-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 256473-81-1 ]

[ 256473-81-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4857-42-5 ]
  • [ 68-12-2 ]
  • [ 256473-81-1 ]
YieldReaction ConditionsOperation in experiment
To a solution of 1 (3g) in THF(60mL) was added n-Butyllithium(32.9mL, 1.58M hexane solution) at -78 °C under N2 atmosphere, then the reaction solution was allowed warm up to -30 °C. After cooling again to -78 °C, dimethylformamide(3.66mL) in THF(10mL) was added to the reaction solution and allowed warm up to 0 °C. After termination of this reaction, dilute hydrochloric acid was added to the solution. The solution was partitioned between water and Et2O, extracted with Et2O and washed with brine. The extraction was back extracted with sat.NaHCO3 soln. and the back extraction was washed with Et2O. It was neutralized with conc.HCl, extracted with Et2O, washed with brine, dried with MgSO4 and concentrated in vacuo to give 11 (2.32g).
 

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