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Chemical Structure| 25666-51-7 Chemical Structure| 25666-51-7

Structure of 25666-51-7

Chemical Structure| 25666-51-7

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Product Details of [ 25666-51-7 ]

CAS No. :25666-51-7
Formula : C8H5F3O2
M.W : 190.12
SMILES Code : OC1=CC=CC=C1C(C(F)(F)F)=O
MDL No. :MFCD06657950

Safety of [ 25666-51-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H312-H315-H319-H332-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 25666-51-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25666-51-7 ]

[ 25666-51-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 25666-51-7 ]
  • [ 262373-15-9 ]
  • 2-methyl-9-(trifluoromethyl)-9H-xanthen-9-ol [ No CAS ]
  • 1-methyl-9-(trifluoromethyl)-9H-xanthen-9-ol [ No CAS ]
YieldReaction ConditionsOperation in experiment
With cesium fluoride; In tetrahydrofuran;Inert atmosphere; Reflux; General procedure: CsF (45 mg, 0.3 mmol) and aryne precursor 2a(44.7 mg, 0.15 mmol) were added to a solution of 2-tirfluoroacetylphenol 1a (19 mg, 0.1 mmol) in dry THF (1.0 mL) under nitrogen. After addition, the resulting mixture was stirred in refluxing THF until full consumption of the starting 2-tirfluoroacetylphenol indicated by TLC. The solvent was removed under reduced pressure and the crude material was purified by column chromatography (PE-EtOAc, 10:1) to afford the pure desired product.
 

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