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Chemical Structure| 256935-99-6 Chemical Structure| 256935-99-6

Structure of 256935-99-6

Chemical Structure| 256935-99-6

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Product Details of [ 256935-99-6 ]

CAS No. :256935-99-6
Formula : C9H6FNO2
M.W : 179.15
SMILES Code : O=C(C1=CC2=C(NC=C2)C(F)=C1)O
MDL No. :MFCD06656875

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Application In Synthesis of [ 256935-99-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 256935-99-6 ]

[ 256935-99-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 883500-73-0 ]
  • [ 124-38-9 ]
  • [ 256935-99-6 ]
YieldReaction ConditionsOperation in experiment
To a solution of <strong>[883500-73-0]5-bromo-7-fluoroindole</strong> 21a (1.71 mmol, 365 mg) in THF at -60 C. was added n-BuLi (1.6 M solution in hexanes, 5.2 mmol, 3.2 mL). The solution was kept at -60 C. for 4 h and was then poured onto an excess of freshly crushed dry ice. Water was added and the mixture was acidified to pH 4. The organic phase was concentrated and the residue was purified by flash column chromatography (silica gel, 35% EtOAc/hexanes) to give compound 21b.
  • 2
  • [ 883500-73-0 ]
  • [ 256935-99-6 ]
YieldReaction ConditionsOperation in experiment
A. 7-Fluoro-1H-indole-5-carboxylic acid, 21b. To a solution of <strong>[883500-73-0]5-bromo-7-fluoroindole</strong> 21a (1.71 mmol, 365 mg) in THF at -60 C. was added n-BuLi (1.6 M solution in hexanes, 5.2 mmol, 3.2 mL). The solution was kept at -60 C. for 4 h and was then poured onto an excess of freshly crushed dry ice. Water was added and the mixture was acidified to pH 4. The organic phase was concentrated and the residue was purified by flash column chromatography (silica gel, 35% EtOAc/hexanes) to give compound 21b.
 

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