Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 25746-87-6 | MDL No. : | MFCD06738842 |
Formula : | C7H10N2O2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | QZBWJPFALVAAPM-UHFFFAOYSA-N |
M.W : | 154.17 | Pubchem ID : | 12440240 |
Synonyms : |
4-Pyrimidinecarboxaldehyde, dimethyl acetal
|
Chemical Name : | 4-Dimethoxymethylpyrimidine |
Num. heavy atoms : | 11 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.43 |
Num. rotatable bonds : | 3 |
Num. H-bond acceptors : | 4.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 38.78 |
TPSA : | 44.24 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -7.33 cm/s |
Log Po/w (iLOGP) : | 1.91 |
Log Po/w (XLOGP3) : | -0.13 |
Log Po/w (WLOGP) : | 0.44 |
Log Po/w (MLOGP) : | -0.43 |
Log Po/w (SILICOS-IT) : | 0.84 |
Consensus Log Po/w : | 0.53 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -0.92 |
Solubility : | 18.6 mg/ml ; 0.12 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.35 |
Solubility : | 69.6 mg/ml ; 0.452 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -1.94 |
Solubility : | 1.77 mg/ml ; 0.0115 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.86 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
26% | With sulfuric acid In chloroform; water | c) Pyrimidine-4-carbaldehyde A solution of 4-dimethoxymethyl-pyrimidine (30.6 g, 199 mmol) in water (235 mL) and concentrated sulfuric acid (2.9 g, 30 mmol) was heated at 60° C. for 24 h. After cooling to room temperature the pH was set to 8 with saturated aqueous sodium hydrogen carbonate solution. The mixture was then extracted overnight in a continuous extraction (Keberle) for 48 h with chloroform. The chloroform extract was then dried over sodium sulfate, filtered and evaporated. Purification by chromatography (SiO2, dichloromethane:methanol=1:0 to 95:5) afforded the title compound (8.1 g, 26percent) which was obtained as a brown oil. MS: m/e=108.0 [M]+. |
26% | With hydrogenchloride In water at 60 - 70℃; for 24 h; | Pyrimidine-4-carbaldehyde (C12) A solution of 4-(dimethoxymethyl)pyrimidine (C11) (90 g, 0.58 mol) and concentrated hydrochloric acid (10 mL) in water (300 mL) was heated at 60-70° C. for 24 hours. The mixture was cooled and evaporated under reduced pressure to afford a glass-like mass, which was basified with aqueous potassium carbonate solution and extracted with ethyl acetate. The combined organic layers were concentrated in vacuo, and the residue was purified by distillation to afford the product as an oil. Yield: 16.3 g, 0.15 mol, 26percent. GCMS m/z 108.0 (M+). 1H NMR (400 MHz, DMSO-d6) δ 7.90 (dd, J=5.0, 1.5 Hz, 1H), 9.14 (d, J=5.0 Hz, 1H), 9.49 (d, J=1.5 Hz, 1H), 9.96 (s, 1H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
64% | at 110 - 120℃; for 4 h; | 4-(Dimethoxymethyl)pyrimidine (C11) A mixture of (3E)-4-(dimethylamino)-1,1-dimethoxybut-3-en-2-one (C10) (147 g, 0.85 mol) and formamidine acetate (131 g, 1.26 mol) was heated at 110-120° C. for 4 hours. After cooling to room temperature, the reaction was poured into water (250 mL) and extracted with chloroform (5*100 mL). The combined organic layers were dried over sodium sulfate, filtered, and concentrated in vacuo. Distillation of the residue under vacuum afforded the product as an oil. Yield: 84 g, 0.54 mol, 64percent. Boiling point: 45-50° C./0.2 torr. NMR data was obtained using the product of a reaction run under similar conditions. 1H NMR (400 MHz, CDCl3) δ 3.30 (s, 6H), 5.21 (s, 1H), 7.46 (dd, J=5.1, 1.4 Hz, 1H), 8.68 (d, J=5.1 Hz, 1H), 9.12 (d, J=1.4 Hz, 1H). |
[ 165807-05-6 ]
4-Dimethoxymethylpyrimidin-2-ylamine
Similarity: 0.89
[ 175277-33-5 ]
4-(Dimethoxymethyl)-2-methylpyrimidine
Similarity: 0.87
[ 180869-38-9 ]
4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine
Similarity: 0.81
[ 193746-84-8 ]
4-(Dimethoxymethyl)-2-methoxypyrimidine
Similarity: 0.80
[ 914347-52-7 ]
5-Bromo-4-(dimethoxymethyl)pyrimidin-2-amine
Similarity: 0.72
[ 165807-05-6 ]
4-Dimethoxymethylpyrimidin-2-ylamine
Similarity: 0.89
[ 175277-33-5 ]
4-(Dimethoxymethyl)-2-methylpyrimidine
Similarity: 0.87
[ 180869-38-9 ]
4-(Dimethoxymethyl)-N-methylpyrimidin-2-amine
Similarity: 0.81
[ 193746-84-8 ]
4-(Dimethoxymethyl)-2-methoxypyrimidine
Similarity: 0.80