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Chemical Structure| 258343-71-4 Chemical Structure| 258343-71-4

Structure of 258343-71-4

Chemical Structure| 258343-71-4

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Product Details of [ 258343-71-4 ]

CAS No. :258343-71-4
Formula : C7H7FN2O
M.W : 154.14
SMILES Code : CC(NC1=NC(F)=CC=C1)=O
MDL No. :MFCD11110987

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Application In Synthesis of [ 258343-71-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 258343-71-4 ]

[ 258343-71-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1597-32-6 ]
  • [ 75-36-5 ]
  • [ 258343-71-4 ]
YieldReaction ConditionsOperation in experiment
58% With triethylamine; In dichloromethane; at 0 - 20℃; for 16h; To a solution of <strong>[1597-32-6]6-fluoropyridin-2-amine</strong> (5.0 g, 45 mmol, Apollo scientific) in dichloromethane (100 mL) were added Et3N (15.54 mL, 112 mmol) and acetyl chloride (4.76 mL, 66.9 mmol) at 0 C. The reaction mixture was stirred at room temperature for 16 h before it was diluted with water and was extracted with dichloromethane. The organic extract was washed with brine, dried over Na2SO4, filtered, concentrated and purified by flash column chromatography, eluting with a gradient of 0 % to 20 % ethyl acetate in petroleum ether to provide N-(6-fluoropyridin-2-yl)acetamide (4.0 g, 26 mmol, 58% yield) as pale yellow solid.1H NMR (400 MHz, DMSO-d6): d ppm 10.65 (s, 1 H), 7.93- 8.01 (m, 2 H), 6.29 (d, J=2.6 Hz, 1 H), 2.09 (s, 3 H). m/z (ESI): 155.1 (M+H)+.
 

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