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Chemical Structure| 25846-90-6 Chemical Structure| 25846-90-6

Structure of 25846-90-6

Chemical Structure| 25846-90-6

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Product Details of [ 25846-90-6 ]

CAS No. :25846-90-6
Formula : C7H2Cl3N3
M.W : 234.47
SMILES Code : ClC1=CN=C(N=C(Cl)C(Cl)=N2)C2=C1
MDL No. :MFCD29089334

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Application In Synthesis of [ 25846-90-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 25846-90-6 ]

[ 25846-90-6 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 25846-90-6 ]
  • [ 159877-36-8 ]
  • tert-butyl 6-(2,7-dichloropyrido[2,3-b]pyrazin-3-yl)octahydro-1H-pyrrolo[3,4-b]pyridin-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
61% With triethylamine; In dichloromethane; at 0 - 20℃; for 2h; 2,3,7-Trichloropyrido[2,3-b]pyrazine (150.0 mg, 0.64 mmol) was dissolved in DCM (6.0 mL). tert-Butyl octahydro-1H-pyrrolo[3,4-b]pyridin-1-carboxylate (151.0 mg, 0.67 mmol) and TEA (288.0 muL, 1.92 mmol) were then added to the mixture at 0 C. The reaction mixture was stirred at room temperature for 2 hours and then diluted in DCM. The organic layer was washed water and brine, dried over anhydrous MgSO4, filtered and then concentrated under reduced pressure. The residue was purified by column chromatography (n-Hex:EtOAc=3:1) on amine silica. The fractions containing the product were collected and concentrated to obtain ivory solid compound of tert-butyl 6-(2,7-dichloropyrido[2,3-b]pyrazin-3-yl)octahydro-1H-pyrrolo[3,4-b]pyridin-1-carboxylate (173.0 mg, 61%). [0993] LCMS ESI(+): 424(M+1), 426(M+3) [0994] 1H-NMR (300 MHz, DMSO-d6); delta: 8.81 (d, 1H, J=2.7 Hz), 8.38 (d, 1H, J=2.7 Hz), 4.69 (m, 1H), 4.00-3.80 (m, 4H), 3.70 (m, 1H), 2.85 (m, 1H), 2.26 (m, 1H), 1.77-1.61 (m, 2H), 1.42 (s, 9H), 1.38-1.26 (m, 2H)
  • 2
  • [ 25846-90-6 ]
  • [ 392338-15-7 ]
  • (R)-tert-butyl (1-(2,7-dichloropyrido[2,3-b]pyrazin-3-yl)pyrrolidin-3-yl)(methyl)carbamate [ No CAS ]
 

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