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Chemistry
Heterocyclic Building Blocks
Isoxazoles
2-Bromo-1-(3-(4-chlorophenyl)isoxazol-5-yl)ethanone
Chemistry
Heterocyclic Building Blocks
Organic Building Blocks
Isoxazoles
Aryls Bromides Chlorides Ketones

[ CAS No. 258506-49-9 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
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Chemical Structure| 258506-49-9
Chemical Structure| 258506-49-9
Structure of 258506-49-9 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 258506-49-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 258506-49-9 ]

SDS Specification
Alternatived Products of [ 258506-49-9 ]

Product Details of [ 258506-49-9 ]

CAS No. :258506-49-9 MDL No. :MFCD00662759
Formula : C11H7BrClNO2 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 300.54 Pubchem ID :-
Synonyms :

Safety of [ 258506-49-9 ]

Signal Word:Danger Class:8
Precautionary Statements:P260-P264-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P321-P363-P405-P501 UN#:1759
Hazard Statements:H314 Packing Group:Ⅲ
GHS Pictogram:

Application In Synthesis of [ 258506-49-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 258506-49-9 ]

[ 258506-49-9 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 37091-33-1 ]
  • [ 258506-49-9 ]
YieldReaction ConditionsOperation in experiment
With bromine In dichloromethane at 0 - 5℃; for 3h;
Reference： [1]Srivastava, Seema; Bajpai, Lakshmi Kant; Batra, Sanjay; Bhaduri, Amiya P.; Maikhuri; Gupta, Gopal; Dhar [Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2607 - 2613]
  • 2
  • 1-[3-(4-chloro-phenyl)-4,5-dihydro-isoxazol-5-yl]-ethanone [ No CAS ]
  • [ 258506-49-9 ]
YieldReaction ConditionsOperation in experiment
With bromine In dichloromethane for 3h; Photolysis;
Multi-step reaction with 2 steps 1: NBS; AIBN / CCl4 / 1 h / 65 °C 2: Br2 / CH2Cl2 / 3 h / 0 - 5 °C
Multi-step reaction with 2 steps 1: Br2 / CH2Cl2 / 1.5 h / 0 - 5 °C / Photolysis 2: Br2 / CH2Cl2 / 2 h
Reference： [1]Srivastava, Seema; Bajpai, Lakshmi Kant; Batra, Sanjay; Bhaduri, Amiya P.; Maikhuri; Gupta, Gopal; Dhar [Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2607 - 2613]
[2]Srivastava, Seema; Bajpai, Lakshmi Kant; Batra, Sanjay; Bhaduri, Amiya P.; Maikhuri; Gupta, Gopal; Dhar [Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2607 - 2613]
[3]Srivastava, Seema; Bajpai, Lakshmi Kant; Batra, Sanjay; Bhaduri, Amiya P.; Maikhuri; Gupta, Gopal; Dhar [Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2607 - 2613]
  • 3
  • [ 258506-52-4 ]
  • [ 258506-49-9 ]
YieldReaction ConditionsOperation in experiment
With bromine In dichloromethane for 2h;
Reference： [1]Srivastava, Seema; Bajpai, Lakshmi Kant; Batra, Sanjay; Bhaduri, Amiya P.; Maikhuri; Gupta, Gopal; Dhar [Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2607 - 2613]
  • 4
  • [ 258506-49-9 ]
  • 2,2-dibromo-1-[3-(4-chloro-phenyl)-isoxazol-5-yl]-ethanone [ No CAS ]
YieldReaction ConditionsOperation in experiment
With bromine In dichloromethane at 0 - 5℃; for 6h;
Reference： [1]Srivastava, Seema; Bajpai, Lakshmi Kant; Batra, Sanjay; Bhaduri, Amiya P.; Maikhuri; Gupta, Gopal; Dhar [Bioorganic and Medicinal Chemistry, 1999, vol. 7, # 11, p. 2607 - 2613]
  • 5
  • 1-(3-(methylthio)phenyl)thiourea [ No CAS ]
  • [ 258506-49-9 ]
  • 4-(3-(4-chlorophenyl)isoxazol-5-yl)-N-(3-(methylthio)phenyl)thiazol-2-amine [ No CAS ]
YieldReaction ConditionsOperation in experiment
75% In ethanol Reflux; 7 4.1.5. General procedure for the synthesis of aminoarylthiazole analogues (Hantzsch synthesis) General procedure: Haloketones (1 eq) were conjugated with thioureas (1 eq) in anhydrous EtOH (1 ml). Reaction was stirred at reflux from 2 to 24 h until the reaction was judged complete (HPLC-MS). The mixture was then extracted with ethyl acetate (3 x 3 ml). The organic phases were concentrated in vacuum and lyophilized. Products were verified by HPLC and MS and purified with preparative HPLC. Relevant fractions were collected and concentrated to afford the desired product in 40-95% yields, with purity of >95% as determined by HPLC-MS.
Reference： [1]Pesce, Emanuela; Bellotti, Marta; Liessi, Nara; Guariento, Sara; Damonte, Gianluca; Cichero, Elena; Galatini, Andrea; Salis, Annalisa; Gianotti, Ambra; Pedemonte, Nicoletta; Zegarra-Moran, Olga; Fossa, Paola; Galietta, Luis J.V.; Millo, Enrico [European Journal of Medicinal Chemistry, 2015, vol. 99, p. 14 - 35]

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