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[ CAS No. 261710-79-6 ] {[proInfo.proName]}

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Chemical Structure| 261710-79-6
Chemical Structure| 261710-79-6
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Product Details of [ 261710-79-6 ]

CAS No. :261710-79-6 MDL No. :MFCD10700245
Formula : C5H5NOS Boiling Point : -
Linear Structure Formula :- InChI Key :BEVOHAAXXVHNQE-UHFFFAOYSA-N
M.W : 127.16 Pubchem ID :11094627
Synonyms :

Safety of [ 261710-79-6 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H317-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 261710-79-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 261710-79-6 ]
  • Downstream synthetic route of [ 261710-79-6 ]

[ 261710-79-6 ] Synthesis Path-Upstream   1~2

  • 1
  • [ 61323-26-0 ]
  • [ 261710-79-6 ]
YieldReaction ConditionsOperation in experiment
54% With diisobutylaluminium hydride In tetrahydrofuran; toluene at -78℃; for 0.5 h; Inert atmosphere Step 1: 5-Methylthiazole-4-carbaldehyde. [00670] To a solution of ethyl 5-methylthiazole-4-carboxylate (794 mg, 5.05 mmol) in THF (21.6 mL) was added dropwise 1.0 M of DIBAL-H in toluene (5.56 mL, 5.56 mmol) under an atmosphere of argon at -78 °C and the reaction was stirred for 30 min. The reaction was quenched with water ( 12.4 mL) at -78 °C. The reaction was warmed to rt. The reaction was poured into 300 mL of saturated Rochelle salt in water and diluted with EtOAc. The layers were stirred together for 1 hour. The layers were separated and the aqueous layer was extracted with EtOAc (x3). The combined organics were washed with brine, dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by ISCO column chromatography ( 10percent EtOAc in DCM as eluent) to give 642 mg (54 percent) of the title compound as yellow oil. NMR (400 MHz, Chloroform-if) δ 10.22 (s, 1 H), 8.62 (s, 1H), 2.83 (s, 3H).
Reference: [1] Journal of Medicinal Chemistry, 2001, vol. 44, # 14, p. 2319 - 2332
[2] Patent: WO2016/4136, 2016, A1, . Location in patent: Paragraph 00670
  • 2
  • [ 61323-26-0 ]
  • [ 261710-79-6 ]
Reference: [1] Patent: US6528510, 2003, B1,
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