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Chemical Structure| 261947-64-2 Chemical Structure| 261947-64-2

Structure of 261947-64-2

Chemical Structure| 261947-64-2

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Product Details of [ 261947-64-2 ]

CAS No. :261947-64-2
Formula : C15H19F3N2O2
M.W : 316.32
SMILES Code : O=C(N1[C@H](CC)C[C@H](N)C2=C1C=CC(C(F)(F)F)=C2)OCC

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Application In Synthesis of [ 261947-64-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 261947-64-2 ]

[ 261947-64-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3034-47-7 ]
  • [ 261947-64-2 ]
  • (2R,4S)-2-ethyl-4-(5-nitrothiazol-2-yl)amino-6-trifluoromethyl-3,4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester [ No CAS ]
YieldReaction ConditionsOperation in experiment
In DMF (N,N-dimethyl-formamide); at 100℃; for 3.0h; (2R, 4S) -4-Amino-2-ethyl-6-trifluoromethyl-3, 4-dihydro-2H- quinoline-1-carboxylic acid ethyl ester (200 mg) and 2-chloro-5-nitro- thiazole (416 mg) are dissolved in N, N-dimethylformamide (1 ml), and the mixture is stirred at 100°C for 3 hours. The reaction solution is cooled to room temperature, and thereto are added an aqueous citric acid solution and ethyl acetate. The organic layer is washed with a saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The resulting residue is purified by column chromatography (silica gel; hexane : ethyl acetate = 4: 1No.1 : 1) to give (2R, 4S)-2-ethyl-4-(5-nitorthiazol-2- yl) amino-6-trifluoromethyl-3, 4-dihydro-2H-quinoline-1-carboxylic acid ethyl ester (148 mg). MS (m/z): 445 [M+H] +
 

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