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Chemical Structure| 26231-89-0 Chemical Structure| 26231-89-0

Structure of 26231-89-0

Chemical Structure| 26231-89-0

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Product Details of [ 26231-89-0 ]

CAS No. :26231-89-0
Formula : C9H8O2
M.W : 148.16
SMILES Code : O=C/C=C/C1=CC=CC(O)=C1

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Application In Synthesis of [ 26231-89-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 26231-89-0 ]

[ 26231-89-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1080-12-2 ]
  • [ 26231-89-0 ]
  • [ 1612860-91-9 ]
YieldReaction ConditionsOperation in experiment
45% With sodium hydroxide; In ethanol; water; at 0 - 20℃; General procedure: To a solution of each of substituted 4-phenylbut-3-en-2-ones(7a1-d1, 7e, 7f and 7c3) and substituted 3-phenylacrylaldehydes (8a1-d1, 8c3 and 8a2-b2) in ethanol was added 20% (w/v) aqueous NaOH at 0-5 C. The mixture was allowed to stir at ambient temperature until the starting material was consumed, during which time the progress of the reaction was monitored by TLC. Development of dark orange coloration indicated that the reaction has taken place. Ethanol was removed in vacuo; ice-water was added to the residue and the solution was neutralized with cold 3M HCl (or acidified to pH ca. 1-2 in the case of 4 and 5, the intermediates 3-phenylacrylaldehydes 8a2 and 8b2 were used, respectively). The solid was collected by vacuum filtration (or extracted with EtOAc and the solvent was evaporated to dryness), washed with water and dried. The residue was purified by column chromatography or recrystallized from appropriate solvent system to provide the substituted trienone analogues 4, 5, 9-15 and 17-20.
 

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