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Chemical Structure| 264927-53-9 Chemical Structure| 264927-53-9

Structure of 264927-53-9

Chemical Structure| 264927-53-9

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Product Details of [ 264927-53-9 ]

CAS No. :264927-53-9
Formula : C8H5ClFIO2
M.W : 314.48
SMILES Code : O=C(OC)C1=CC(I)=C(F)C=C1Cl
MDL No. :MFCD24107116

Safety of [ 264927-53-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 264927-53-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 264927-53-9 ]

[ 264927-53-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 264927-52-8 ]
  • [ 264927-53-9 ]
  • [ 264927-54-0 ]
YieldReaction ConditionsOperation in experiment
With thionyl chloride; In methanol; b Methyl 2-chloro-4-fluoro-5-iodobenzoate 30.8 g of <strong>[264927-52-8]2-chloro-4-fluoro-5-iodobenzoic acid</strong> were dissolved in 300 ml of MeOH and 36 ml of thionyl chloride were added dropwise. The mixture was refluxed for 4 hours and the volatile constituents were removed in vacuo. The residue was taken up using 600 ml of EA and washed with 400 ml of a half-concentrated aqueous Na2 CO3 solution. The organic phase was dried over Na2 SO4 and the solvent was removed in vacuo. The residue was stirred with 200 ml of HEP, and the precipitate was filtered off and washed with 100 ml of HEP. 5.8 g of methyl 2-chloro-4-fluoro-3,5-diiodobenzoate were obtained, mp 155 C. The solvent was removed in vacuo from the filtrate containing the desired product and 23.5 g of white crystals were obtained, mp 52 C.
 

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