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Chemical Structure| 2650-65-9 Chemical Structure| 2650-65-9

Structure of H-Gln-Gly-OH
CAS No.: 2650-65-9

Chemical Structure| 2650-65-9

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Product Details of [ 2650-65-9 ]

CAS No. :2650-65-9
Formula : C7H13N3O4
M.W : 203.20
SMILES Code : O=C(O)CNC([C@@H](N)CCC(N)=O)=O
MDL No. :MFCD00038160

Safety of [ 2650-65-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319
Precautionary Statements:P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330

Application In Synthesis of [ 2650-65-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2650-65-9 ]

[ 2650-65-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2650-65-9 ]
  • [ 1426827-79-3 ]
  • cyclooctynecyclopropyl-CH2-OC(O)NH-Q-G [ No CAS ]
YieldReaction ConditionsOperation in experiment
49% With N-ethyl-N,N-diisopropylamine; In water; dimethyl sulfoxide; at 35 - 40℃; for 1h; Commercially available QG (92 mg, 0.316 mmol) and Huenig's Base (64.5 μL, 0.369 mmol) were dissolved in 2 mL of 1:1 Water:DMSO and warmed to 35 C. Commercially available Click-easy BCN N-hydroxysuccinimide ester I (50 mg, 0.246 mmol) was dissolved in 2 mL of DMSO and slowly added to the reaction. The reaction mixed at 40 C. for 1 hr. The product was purified by column chromatography (20 g C-18, 0-70 MeCN/Water). Product eluted around 50% MeCN. Yield: 46 mg (49% yield). 1H NMR (400 MHz, DMSO-d6) δ ppm 0.87 (t, J=9.66 Hz, 2 H) 1.27 (quin, J=8.53 Hz, 1 H) 1.52 (d, J=10.88 Hz, 2 H) 1.62-1.75 (m, 1 H) 1.81-1.95 (m, 1 H) 2.04-2.25 (m, 8 H) 3.14 (br. s., 1 H) 3.49-3.73 (m, 2 H) 3.89-3.99 (m, 1 H) 4.05 (d, J=7.95 Hz, 2 H) 6.72 (br. s., 1 H) 7.21-7.31 (m, 2 H) 7.88 (br. s., 1 H); HRMS calculated for (C18H25N3O6): 379.1743 observed: (M+1) 380.1811.
 

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