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Chemical Structure| 266353-32-6 Chemical Structure| 266353-32-6

Structure of 266353-32-6

Chemical Structure| 266353-32-6

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Product Details of [ 266353-32-6 ]

CAS No. :266353-32-6
Formula : C6H4N2O4
M.W : 168.11
SMILES Code : O=[N+](C1=CC=[N+]([O-])C=C1C=O)[O-]

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Application In Synthesis of [ 266353-32-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 266353-32-6 ]

[ 266353-32-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 266353-32-6 ]
  • [ 218609-00-8 ]
  • 3-[2-(tert-butoxycarbonylamino)-2-(methoxycarbonyl)ethenyl]-4-nitropyridine-1-oxide [ No CAS ]
YieldReaction ConditionsOperation in experiment
64% With N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; at -78.0℃; for 3.0h; Intermediate 15: 3-[ 2-(tert-Butoxycarbonviamino)-2-(methoxvcarbonyl)ethenyll-4- nitrojpyridine-1-oxide; Methyl [(tert-butoxycarbonyl)amino](dimethoxyphosphoryl)acetate (1.633 g , 5.5 mmol) was dissolved in dry THF (30 ml) and cooled to-78 C under nitrogen. Tetramethylguanidine (603 mg. , 5.25 mmol) was added and the solution stirred at-78 C for a further 15 mins. A slurry of 4-nitronicotinaldehyde-N-oxide (Eur. J.Med.Chem. 2000, 35(1), 77-82,850 mg, 5 mmol), in dry THF (5 ml) was added and stirred at-78 C for 3 hours. Water (100 ml) was added and the aqueous phase was extracted with ethyl acetate (3x50ml). The combined extracts were washed with water (2 x 20 ml) and brine (20 ml), dried (MgS04) and evaporated under reduced pressure to give a yellow oil, which was triturated with ether to give the title compound (1.08 g, 64%) as a yellow solid. ¹H NMR: 1.3 (s, 9H) ; 3.8 (s, 3H) ; 7.1 (s, 1H); 8.15 (m, 2H) ; 8.35 (d, 1H) ; 8.85 (s,lH); MS: 338 (M-H) +.
 

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