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Chemical Structure| 268209-15-0 Chemical Structure| 268209-15-0

Structure of 268209-15-0

Chemical Structure| 268209-15-0

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Product Details of [ 268209-15-0 ]

CAS No. :268209-15-0
Formula : C19H27FN4O4
M.W : 394.44
SMILES Code : O=C(N1CCN(C2=CC=C(N3C(O[C@@H](CN)C3)=O)C=C2F)CC1)OC(C)(C)C

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Application In Synthesis of [ 268209-15-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 268209-15-0 ]

[ 268209-15-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 268209-15-0 ]
  • [ 10241-97-1 ]
  • (S)-tert-butyl 4-(2-fluoro-4-(5-((5-methyl-1H-indole-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)piperazine-1-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20℃;Inert atmosphere; General procedure: Compound 11a prepared by amide bond formation between (R)-5-(amino methyl)-3-(3-fluoro-4-thiomorpholinophenyl)oxazolidin-2-one (8b, 155 mg, 0.50 mmol) and (E)-2,3-diphenylacrylic acid (156 mg, 0.7 mmol) in dry CH2Cl2. The coupling reagents EDC (1.2 mmol) and HOBt (1.2 mmol) were added, and the reaction mixture was stirred at room temperature for 10 h. After completion of reaction as indicated by TLC, the reaction mixture was quenched with NaHCO3 and extracted in EtOAc (4 x 25 ml) from the ice-cold aqueous layer and dried over anhydrous MgSO4. The resulting product 10a was purified by column chromatography to afford 232 mg, a yellow solid.
 

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