Home Cart Sign in  
Chemical Structure| 2693-46-1 Chemical Structure| 2693-46-1

Structure of 2693-46-1

Chemical Structure| 2693-46-1

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Hong, Sumin ; Han, Eunjung ; Park, Saemi ; Hyun, Kyungtae ; Lee, Yunkyoung ; Baek, Hyun woo , et al.

Abstract: Gentamicin-induced ototoxicity leads to irreversible sensorineural hearing loss due to structural and functional damage to inner ear hair cells. In this study, we identified (-)-butaclamol as a potent protective agent against gentamicin‑induced cytotoxicity through high-content screening (HCS) of a natural compound library. (-)-Butaclamol significantly enhanced cell viability in both HEI-OC1 cells and zebrafish neuromasts, demonstrating robust protection against gentamicin toxicity. Mechanistically, (-)-butaclamol inhibited intrinsic , as evidenced by reduced TUNEL-positive cell counts and the downregulation of BAX and caspase-3, alongside the upregulation of . Moreover, (-)-butaclamol activated key survival signaling pathways, including AKT/mTOR and , while suppressing the inflammatory regulator . Additional analyses revealed that (-)-butaclamol effectively mitigated oxidative stress and restored autophagic activity, as confirmed by CellROX and LysoTracker assays. Notably, staining showed that (-)-butaclamol preserved mitochondrial membrane potential in zebrafish hair cells, indicating mitochondrial protection. Collectively, these findings suggest that (-)-butaclamol exerts comprehensive cytoprotective effects against gentamicin-induced ototoxicity by modulating , enhancing survival signaling, and restoring mitochondrial and cellular homeostasis. These results highlight the therapeutic potential of (-)-butaclamol and provide a foundation for future studies aimed at its clinical application.

Keywords: (-)-butaclamol ; in vitro ; in vivo ; ototoxicity ; gentamicin ; hair cell

Purchased from AmBeed:

Alternative Products

Product Details of [ 2693-46-1 ]

CAS No. :2693-46-1
Formula : C16H11N
M.W : 217.27
SMILES Code : NC1=CC=C2C3=CC=CC=C3C3=CC=CC1=C23
MDL No. :MFCD00001185
InChI Key :VHGJAFIHUSTRGB-UHFFFAOYSA-N
Pubchem ID :17599

Safety of [ 2693-46-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 2693-46-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2693-46-1 ]

[ 2693-46-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2693-46-1 ]
  • [ 81-16-3 ]
  • C26H15N3 [ No CAS ]
YieldReaction ConditionsOperation in experiment
51% 3-Aminofluoranthene, 10.85 g, 49.94 [MMOL,] is suspended in water, 50 ml, and HCI, 12 M, 10 [ML,] 0.12 mol, at [0C.] Sodium nitrite, 3.50 g, 50.7 [MMOL,] in water, 10 mi, is added dropwise over 15 minutes. After 30 minutes at [0C,] the red-brown solution is filtered. Tobias acid (2- [NAPHTHYLAMINE-1-SULFONIC] acid), 11.15 g, 49.96 [MMOL,] is dissolved in pyridine, 50 ml, and cooled to [0C.] The diazonium salt solution is then added dropwise over 30 minutes at [0C.] After 2 hours, the suspension is filtered, washed with water and dried in vacuo to give a purple-red solid. The material, 15.6 g, 42.0 [MMOL,] is heated in pyridine, 250 ml, to [60C] in a 1 I reactor. Copper [(IL)] sulfate pentahydrate, 26.4 g, 0.105 mol, in water, 100 mi, is added dropwise to the azo compound. The temperature is then raised to [90C] for 4 hours. The mixture is cooled to room temperature and filtered to give a pale brown solid. The compound is purified by crystallization. Yield, 7.9 g, 21.4 mmol, [51%. TM = 155C.] MS [(APCI)] : 370.1 (M+1). The material has a [XMAE] eMAHsion of 478 nm in solution.
 

Historical Records

Categories