Alternatived Products of [ 273222-06-3 ]
Product Details of [ 273222-06-3 ]
CAS No. : | 273222-06-3 |
MDL No. : | MFCD01860707 |
Formula : |
C25H28N2O6
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | FJEXPICLVWOJSE-VFNWGFHPSA-N |
M.W : |
452.50
|
Pubchem ID : | 44118846 |
Synonyms : |
|
Safety of [ 273222-06-3 ]
Application In Synthesis of [ 273222-06-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 273222-06-3 ]
- Downstream synthetic route of [ 273222-06-3 ]
- 1
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(2S,4R)-H-Amp(Boc)-OH
[ No CAS ]
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[ 82911-69-1 ]
-
[ 273222-06-3 ]
- 2
-
[ 273222-06-3 ]
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(1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carboxamide hydrochloride
[ No CAS ]
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(2S,4R)-4-tert-Butoxycarbonylamino-2-((1S,3S,5S)-3-carbamoyl-2-aza-bicyclo[3.1.0]hexane-2-carbonyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
[ No CAS ]
- 3
-
[ 273222-06-3 ]
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Fmoc-D-Tyr(O-tBu)-OH
[ No CAS ]
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N-(9-fluorenylmethoxycarbonyl)-3-(β-naphthyl)-L-alanine
[ No CAS ]
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Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine
[ No CAS ]
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Fmoc-Gly-OH
[ No CAS ]
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C58H79N11O12S
[ No CAS ]
- 4
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[ 28920-43-6 ]
-
[ 473806-21-2 ]
-
[ 273222-06-3 ]
- 5
-
[ 853063-25-9 ]
-
[ 273222-06-3 ]
- 6
-
[ 273222-06-3 ]
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[(3R,5S)-5-((1S,3S,5S)-3-Cyano-2-aza-bicyclo[3.1.0]hexane-2-carbonyl)-pyrrolidin-3-yl]-carbamic acid tert-butyl ester
[ No CAS ]
- 7
-
[ 273222-06-3 ]
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(2S,4R)-4-tert-Butoxycarbonylamino-2-((1S,3S,5S)-3-cyano-2-aza-bicyclo[3.1.0]hexane-2-carbonyl)-pyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
[ No CAS ]
- 8
-
[ 24424-99-5 ]
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1.) NaH; 2.) SOCl2
[ No CAS ]
-
[ 273222-06-3 ]
- 9
-
[ 329191-66-4 ]
-
[ 273222-06-3 ]
- 10
-
[ 273222-06-3 ]
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Fmoc-Rink resin
[ No CAS ]
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[ 35661-40-6 ]
-
[ 108-24-7 ]
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C101H158N20O29
[ No CAS ]
- 11
-
[ 273222-06-3 ]
-
[ 29022-11-5 ]
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Fmoc-Hyp(tBu)-OH
[ No CAS ]
-
[ 71989-31-6 ]
-
[ 108-24-7 ]
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Ac-(Gly-Pro-Hyp)3-Gly-Pro-Amp-(Gly-Pro-Hyp)3-Gly-Gly-NH2
[ No CAS ]
- 12
-
[ 273222-06-3 ]
-
[ 67-56-1 ]
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(2S,4R)-1-(9H-fluoren-9-yl)methyl 2-methyl-4-aminopyrrolidine-1,2-dicarboxylate hydrochloride
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With thionyl chloride; at 70.0℃; for 16h;Cooling with ice; |
(2S,4R)-1 -(((9H-fluoren-9-yl)methoxy)carbonyl)-4-(tert-butoxycarbonylam ino)pyrrolidine2-carboxylic acid (1.00 g, 2.210 mmol, 1.00 eq) was dissolved in MeOH (40 ml). Thereaction mixture was placed in an ice-bath followed by the drop-wise addition of neat SOCI2 (526 mg, 4.42 mmol, 2.00 eq). After the addition, the resulting reaction mixture was stirred at 70 C for 16 h. The mixture was concentrated under reduced pressure to provide 890 mg of the title compound as a solid. The crude material was taken to the next step without any further purification. |
- 13
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[ 273222-06-3 ]
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[ 29022-11-5 ]
-
[ 35661-40-6 ]
-
[ 108-24-7 ]
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[ 71989-31-6 ]
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Ac-L-phenylalanine-L-Pro-(4R-amino-L-proline)-Gly-L-Pro-(4R-amino-L-proline)-Gly-L-Pro-(4R-amino-L-proline)-Gly-L-Pro-(4R-amino-L-proline)-Gly-L-Pro-(4R-amino-L-proline)-Gly-L-Pro-(4R-amino-L-proline)-Gly-NH<SUB>2</SUB>
[ No CAS ]