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Chemical Structure| 276862-11-4 Chemical Structure| 276862-11-4

Structure of 276862-11-4

Chemical Structure| 276862-11-4

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Product Details of [ 276862-11-4 ]

CAS No. :276862-11-4
Formula : C7H13F2NO
M.W : 165.18
SMILES Code : OCCN1CCC(F)(F)CC1
MDL No. :MFCD30011127
InChI Key :FIOGEOHNBIXNID-UHFFFAOYSA-N
Pubchem ID :17964029

Safety of [ 276862-11-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H315-H318-H335-H227
Precautionary Statements:P210-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P332+P313-P362-P370+P378-P403+P233-P403+P235-P405-P501
Class:8
UN#:2735
Packing Group:

Application In Synthesis of [ 276862-11-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 276862-11-4 ]

[ 276862-11-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 101990-45-8 ]
  • [ 276862-11-4 ]
  • 2-bromo-5-((2-(4,4-difluoropiperidin-1-yl)ethoxy)methyl)pyridine [ No CAS ]
YieldReaction ConditionsOperation in experiment
1.3 g With sodium hydride; In tetrahydrofuran; at 0 - 20℃; for 4h; To a solution of the compound obtained in the previous section, step b (1 g, 6.1 mmol), NaH (0.72 g, 30.0 mmol) in THF at 0C the compound obtained in the previous section, step a (1.67 g, 6.7 mmol) was added lowly at same temperature and allowed to stir for 4 h from 0C to RT. Reaction was monitored by TLC & LCMS. The reaction mixture was diluted with 40 mL ice cold water and extracted with 2 X 50 mL EtOAC, washed with brine, dried over anhydrous Na2S04, evaporated to get crude 2-bromo-5-((2-(4,4- difluoropiperidin-1-yl)ethoxy)methyl)pyridine (3) as pale yellow liquid. The crude was purified flash column chromatography by 40% EtOAC/Hexane in 100-200 silica to get 1.3 g (64%) of of the title compound as pale yellow liquid. (0776) LC-MS (method 27): R, = 0.41 min; m/z = 337.08 (M+H-+2).
 

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