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Chemical Structure| 27699-93-0 Chemical Structure| 27699-93-0

Structure of 27699-93-0

Chemical Structure| 27699-93-0

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Product Details of [ 27699-93-0 ]

CAS No. :27699-93-0
Formula : C10H6O3
M.W : 174.15
SMILES Code : O=C1C(C=C(O)C2=C1C=CC=C2)=O
MDL No. :N/A

Safety of [ 27699-93-0 ]

Application In Synthesis of [ 27699-93-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 27699-93-0 ]

[ 27699-93-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 4418-61-5 ]
  • [ 52351-75-4 ]
  • [ 27699-93-0 ]
  • 6'-methoxyl-4,6-dihydrospiro[benzo[h]tetrazolo[5,1-b]-quinazoline-4,3'-indoline]-2',7,8-trione [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% In acetic acid; for 7h;Reflux; General procedure: To a mixture of 2-hydroxy-1,4-naphthoquinone (1 mmol), isatin (1 mmol) and CH3COOH10 mL, 5-aminotetrazole (1 mmol) was added. The mixture was stirred at reflux for an appropriatetime (Table 2). After completion of the reaction (TLC), the reaction mixture was cooled to roomtemperature and the solvent was evaporated under reduced pressure. Then, the crude product waswashed sequentially with 20 mL saturated NaHCO3 and 20 mL brine, purified by silica gel columnchromatography using petroleum ether: ethyl acetate (v:v = 1:1) as eluent to afford the pure product 4(the copies of all spectral data see Supplementary Materials).
  • 2
  • [ 4418-61-5 ]
  • [ 391-12-8 ]
  • [ 27699-93-0 ]
  • 7'-trifloromethyl-4,6-dihydrospiro[benzo[h]tetrazolo[5,1-b]-quinazoline-4,3'-indoline]-2',7,8-trione [ No CAS ]
YieldReaction ConditionsOperation in experiment
47% In acetic acid; for 7h;Reflux; General procedure: To a mixture of 2-hydroxy-1,4-naphthoquinone (1 mmol), isatin (1 mmol) and CH3COOH10 mL, 5-aminotetrazole (1 mmol) was added. The mixture was stirred at reflux for an appropriatetime (Table 2). After completion of the reaction (TLC), the reaction mixture was cooled to roomtemperature and the solvent was evaporated under reduced pressure. Then, the crude product waswashed sequentially with 20 mL saturated NaHCO3 and 20 mL brine, purified by silica gel columnchromatography using petroleum ether: ethyl acetate (v:v = 1:1) as eluent to afford the pure product 4(the copies of all spectral data see Supplementary Materials).
 

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