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Chemical Structure| 281234-90-0 Chemical Structure| 281234-90-0

Structure of 281234-90-0

Chemical Structure| 281234-90-0

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Product Details of [ 281234-90-0 ]

CAS No. :281234-90-0
Formula : C12H15N3
M.W : 201.27
SMILES Code : N#CC1=CC=C(N2CCC(N)CC2)C=C1
MDL No. :MFCD11038429

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Application In Synthesis of [ 281234-90-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 281234-90-0 ]

[ 281234-90-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 281234-90-0 ]
  • [ 459-04-1 ]
  • C20H20FN3O [ No CAS ]
YieldReaction ConditionsOperation in experiment
45% With triethylamine; In tetrahydrofuran; at 0 - 20℃; for 16.5h; To a solution of compound 4-(4-aminopiperidin-1-yl)benzonitrile (500 mg, 2.48 mmol) in anhydrous THF (5 mL) was added TEA (754 mg, 7.45 mmol) followed by (4-Fluoro-phenyl)-acetyl chloride (514 mg, 2.98 mmol) at 0 C. After stirring at the temperature for 0.5 hour, the mixture was allowed to warm to 20 C and stirred for 16 hours. The reaction mixture was diluted with water (100 mL), extracted with EtOAc (50 mLx3). The extracts was washed with brine, dried over Na2SO4 and concentrated to give a residue which was purified by silica gel column (eluent: PE/EA = 4/1 to 1/2) to afford 380 mg (yield: 45%) of D1 as a white solid.
 

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