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[ CAS No. 28163-00-0 ]

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Chemical Structure| 28163-00-0
Chemical Structure| 28163-00-0
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CAS No. :28163-00-0 MDL No. :MFCD00052203
Formula : C7H3ClN2O2 Boiling Point : 337°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :182.56 g/mol Pubchem ID :-
Synonyms :

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Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 28163-00-0 ]

  • Upstream synthesis route of [ 28163-00-0 ]
  • Downstream synthetic route of [ 28163-00-0 ]

[ 28163-00-0 ] Synthesis Path-Upstream   1~6

  • 1
  • [ 28163-00-0 ]
  • [ 99-60-5 ]
Reference: [1] Farmaco (1946-1952), 1948, vol. 3, p. 509,523
  • 2
  • [ 28163-00-0 ]
  • [ 3939-09-1 ]
  • [ 60702-69-4 ]
Reference: [1] Journal of Fluorine Chemistry, 1993, vol. 63, # 1-2, p. 25 - 30
  • 3
  • [ 28163-00-0 ]
  • [ 20925-27-3 ]
YieldReaction ConditionsOperation in experiment
78% With hydrazine hydrate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate Step 4
A portion of 2-chloro-4-nitrobenzonitrile (5 g, 0.027 m) was heated with hydrazine monohydrate (110 ml) until the reaction began.
Another portion of 2-chloro-4-nitrobenzonitrile (35 g, 0.192 m) was added in predetermined amounts.
Once the evolution of nitrogen gas ceased, the reaction mixture was refluxed approximately thirty minutes, and then poured into stirred ice water.
The precipitate was filtered and the solid was crystallized from water to yield 2-chloro-4-aminobenzonitrile (25 g, 78percent, mp 117° C.).
Reference: [1] Patent: US4424371, 1984, A,
  • 4
  • [ 67-56-1 ]
  • [ 28163-00-0 ]
  • [ 127666-99-3 ]
Reference: [1] Journal of Organic Chemistry, 1990, vol. 55, # 16, p. 4817 - 4821
  • 5
  • [ 28163-00-0 ]
  • [ 60702-69-4 ]
Reference: [1] Tetrahedron Letters, 2010, vol. 51, # 14, p. 1906 - 1909
  • 6
  • [ 28163-00-0 ]
  • [ 3939-09-1 ]
  • [ 60702-69-4 ]
Reference: [1] Journal of Fluorine Chemistry, 1993, vol. 63, # 1-2, p. 25 - 30
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