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[ CAS No. 28163-00-0 ]

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CAS No. :	28163-00-0	MDL No. :	MFCD00052203
Formula :	C₇H₃ClN₂O₂	Boiling Point :	337°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	182.56 g/mol	Pubchem ID :	-
Synonyms :

Safety of [ 28163-00-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 28163-00-0 ]

Upstream synthesis route of [ 28163-00-0 ]
Downstream synthetic route of [ 28163-00-0 ]

[ 28163-00-0 ] Synthesis Path-Upstream 1~6

1
[ 28163-00-0 ]
[ 99-60-5 ]

Reference： [1] Farmaco (1946-1952), 1948, vol. 3, p. 509,523

2
[ 28163-00-0 ]
[ 3939-09-1 ]
[ 60702-69-4 ]

Reference： [1] Journal of Fluorine Chemistry, 1993, vol. 63, # 1-2, p. 25 - 30

3
[ 28163-00-0 ]
[ 20925-27-3 ]

Yield	Reaction Conditions	Operation in experiment
78%	With hydrazine hydrate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate	Step 4 A portion of 2-chloro-4-nitrobenzonitrile (5 g, 0.027 m) was heated with hydrazine monohydrate (110 ml) until the reaction began. Another portion of 2-chloro-4-nitrobenzonitrile (35 g, 0.192 m) was added in predetermined amounts. Once the evolution of nitrogen gas ceased, the reaction mixture was refluxed approximately thirty minutes, and then poured into stirred ice water. The precipitate was filtered and the solid was crystallized from water to yield 2-chloro-4-aminobenzonitrile (25 g, 78percent, mp 117° C.).

Reference： [1] Patent: US4424371, 1984, A,

4
[ 67-56-1 ]
[ 28163-00-0 ]
[ 127666-99-3 ]

Reference： [1] Journal of Organic Chemistry, 1990, vol. 55, # 16, p. 4817 - 4821

5
[ 28163-00-0 ]
[ 60702-69-4 ]

Reference： [1] Tetrahedron Letters, 2010, vol. 51, # 14, p. 1906 - 1909

6
[ 28163-00-0 ]
[ 3939-09-1 ]
[ 60702-69-4 ]

Reference： [1] Journal of Fluorine Chemistry, 1993, vol. 63, # 1-2, p. 25 - 30

[ 28163-00-0 ] Synthesis Path-Downstream 1~25

1
[ 67-56-1 ]
[ 28163-00-0 ]
[ 127666-99-3 ]

Reference： [1]Journal of Organic Chemistry,1990,vol. 55,p. 4817 - 4821

2
[ 3011-89-0 ]
[ 28163-00-0 ]

Yield	Reaction Conditions	Operation in experiment
79%	With thionyl chloride; In benzene;	Step 3 Thionyl chloride (1,000 g, 8.4 m) was then added to the <strong>[3011-89-0]2-chloro-4-nitrobenzamide</strong> (200 g, 1 m) while the mixture was warmed. After addition, the mixture was refluxed for approximately three hours. The excess thionyl chloride was removed by distillation leaving a reaction mixture residue. Benzene (500 ml) was added to the cold reaction mixture residue to extract the reaction product. The extract was washed with diluted sodium hydroxide solution and water until neutralized and then dried over anhydrous sodium sulfate. The benzene solvent was distilled off and the reaction product was crystallized from methanol to yield 2-chloro-4-nitrobenzonitrile (145 g, 79%, mp 73-75 C.).
	With phosphorus pentachloride; In tetrachloromethane;	D. 4-Nitro-2-chlorobenzonitrile was prepared as follows: A mixture of 18.2 g. <strong>[3011-89-0]2-chloro-4-nitrobenzamide</strong>, 20.9 g. phosphorus pentachloride and 20 ml. carbon tetrachloride was slowly heated till vigorous gas evolution ensued (40C.). Heat was removed till gas evolution became gentle and the solution was heated at reflux for 20 minutes. The solution was evaporated to dryness and the resulting residue was heated till the internal temperature reached 135C. when vigorous bubbling began. Heat was removed till bubbling became gentle and the reaction mixture was heated at 140-145C. (internal) for thirty minutes. The mixture was distilled under pressure to remove phosphorus oxychloride and the resulting residue was crystallized from ethyl alcohol to give 9.6 g. 4-nitro-2-chlorobenzonitrile; m.p. 80-81C.

Reference： [1]Synthesis,1982,p. 591 - 592
[2]Patent: US4424371,1984,A
[3]Zhurnal Obshchei Khimii,1956,vol. 26,p. 905; engl. Ausg. S. 1029
[4]Patent: US3984467,1976,A

3
[ 28163-00-0 ]
[ 3939-09-1 ]
[ 60702-69-4 ]

Reference： [1]Journal of Fluorine Chemistry,1993,vol. 63,p. 25 - 30

4
[ 98606-58-7 ]
[ 28163-00-0 ]
[ 7684-30-2 ]

Yield	Reaction Conditions	Operation in experiment
89%	With dichloromethylenedimethyliminium chloride In 1,2-dichloro-ethane 1.) room temp., 1 h, 2.) reflux, 4 h;

Reference： [1]Kokel, Bruno; Menichi, Gabriel; Hubert-Habart, Michel [Synthesis, 1985, # 2, p. 201 - 202]

5
[ 28163-00-0 ]
[ 140-29-4 ]
(3-chloro-4-cyanophenyl)-phenylacetonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
68%	With potassium <i>tert</i>-butylate In N,N-dimethyl-formamide at 20℃;

Reference： [1]Bech Sommer, Michael; Begtrup, Mikael; Boegesoe, Klaus Peter [Journal of Organic Chemistry, 1990, vol. 55, # 16, p. 4817 - 4821]

6
[ 28163-00-0 ]
[ 127667-07-6 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 89 percent / NaOH 2: 79 percent / potassium tert-butoxide / dimethylformamide / 1 h / 20 °C

Reference： [1]Bech Sommer, Michael; Begtrup, Mikael; Boegesoe, Klaus Peter [Journal of Organic Chemistry, 1990, vol. 55, # 16, p. 4817 - 4821]

7
trans-dichloro(bis(tricyclohexylphosphino))palladium [ No CAS ]
[ 28163-00-0 ]
[ 13922-41-3 ]
2-(1-naphthyl)-4-nitrobenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium carbonate In 1,4-dioxane; ethyl acetate; toluene	287.A 2-(1-naphthyl)-4-nitrobenzonitrile EXAMPLE 287A 2-(1-naphthyl)-4-nitrobenzonitrile A solution of 1-naphthylboronic acid (2.58 g, 15.0 mmol) in toluene (20 mL) and dioxane (20 mL) was treated with 2-chloro-4-nitrobenzonitrile (1.83 g, 10.0 mmol), trans-dichloro(bis(tricyclohexylphosphino))palladium (370 mg, 0.50 mmol), and 2M Na2CO3 (20 mL), purged with nitrogen, heated to reflux, stirred for 19 hours, treated with ethyl acetate, washed with water and brine, dried (MgSO4), filtered, and concentrated. The concentrate was triturated with ethyl acetate/hexanes to provide the desired product. MS (DCI/NH3) m/z 292 (M+NH4)+; 1H NMR (300 MHz, CDCl3) δ 8.41(m, 2H), 8.00 (m, 3H), 7.53(m, 5H).

Reference： [1]Current Patent Assignee: ABBOTT LABORATORIES INC - US2002/19527, 2002, A1

8
[ 28163-00-0 ]
[ 20925-27-3 ]

Yield	Reaction Conditions	Operation in experiment
78%	With hydrazine hydrate; In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;	Step 4 A portion of 2-chloro-4-nitrobenzonitrile (5 g, 0.027 m) was heated with hydrazine monohydrate (110 ml) until the reaction began. Another portion of 2-chloro-4-nitrobenzonitrile (35 g, 0.192 m) was added in predetermined amounts. Once the evolution of nitrogen gas ceased, the reaction mixture was refluxed approximately thirty minutes, and then poured into stirred ice water. The precipitate was filtered and the solid was crystallized from water to yield 2-chloro-4-aminobenzonitrile (25 g, 78%, mp 117 C.).

Reference： [1]Patent: US4424371,1984,A

9
[ 28163-00-0 ]
[ 96898-76-9 ]

Yield	Reaction Conditions	Operation in experiment
68%	With hydroxyamino hydrochloride; triethylamine In ethanol at 20 - 85℃;	4 Example 4; 3-Chloro-4-(5-(8-chloro-6-(trifluor omethyl)-imidazo [ 1 ,2-a] pyridin-2-yl)- 1 ,2,4-oxadiazol-3- yl)benzenaminemethanesulfonate; 2-Chloro-7V'-hydroxy-4-nitrobenzamidine (30).; To a stirred solution of 2-chloro-4- nitrobenzonitrile 29 (5.0 g, 0.027 moles) in EtOH (30 rnL) was added hydroxylamine hydrochloride (9.5g, 0.14 moles) followed by triethylamine (13.8 g, 0.136 mol) at room temperature. After stirring at 85 0C for 2 h, the reaction mixture was concentrated in vacuo and water added to the residue. The product was extracted into EtOAc. The organic layers were combined, washed with water (2x), combined again, dried over Na2Sθ4, and concentrated. The crude product was purified by column chromatography (30% EtOAc/hexane), affording hydroxyimidate 30 (4.0 g, 68% yield) as a yellow solid.
	With hydroxyamino hydrochloride; sodium hydroxide In ethanol; lithium hydroxide monohydrate Reflux;

Reference： [1]Current Patent Assignee: EXELIXIS INC - WO2010/65760, 2010, A1 Location in patent: Page/Page column 115
[2]Bojarski, Andrzej J.; Brański, Piotr; Bugno, Ryszard; Burnat, Grzegorz; Chorobik, Paulina; Chruścicka, Barbara; Duszyńska, Beata; Kaczorowska, Katarzyna; Kozioł, Aneta; Paluchowska, Maria H.; Pilc, Andrzej; Stankiewicz, Anna; Wierońska, Joanna M. [Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, vol. 37, # 1, p. 211 - 225]

10
[ 28163-00-0 ]
[ 60702-69-4 ]

Reference： [1]Tetrahedron Letters,2010,vol. 51,p. 1906 - 1909

11
[ 773837-37-9 ]
None [ No CAS ]
[ 28163-00-0 ]

Yield	Reaction Conditions	Operation in experiment
83%	With copper(l) cyanide at 20℃;

Reference： [1]Habibi, Davood; Heydari, Somayyeh; Nasrollahzadeh, Mahmoud [Journal of Chemical Research, 2012, vol. 36, # 10, p. 573 - 574,2]

12
[ 619-72-7 ]
[ 28163-00-0 ]

Yield	Reaction Conditions	Operation in experiment
83%	With N-chloro-succinimide; palladium diacetate; toluene-4-sulfonic acid In 1,2-dichloro-ethane at 70℃; for 12h; Sealed tube;

Reference： [1]Du, Bingnan; Jiang, Xiaoqing; Sun, Peipei [Journal of Organic Chemistry, 2013, vol. 78, # 6, p. 2786 - 2791]

13
[ 28163-00-0 ]
[ 411235-57-9 ]
[ 1533425-12-5 ]

Yield	Reaction Conditions	Operation in experiment
	With palladium diacetate; potassium carbonate; XPhos In tetrahydrofuran; water at 75℃; for 16h; Inert atmosphere;	35 2-Cyclopropyl-4-nitrobenzonitrile In a Teflon-capped reaction tube, 2-chloro-4-nitrobenzonitrile (450 mg, 2.46 mmol), 2- dicyclohexylphosphino-2',4',6'-triisopropylbiphenyl (X-phos, 118 mg, 0.246 mmol), cyclopropylboronic acid (800 mg, 9.31 mmol), potassium carbonate (1.02 g, 7.39 mmol) and palladium (II) acetate (28 mg, 0.125 mmol) were combined with THF (10 mL) and water (1 mL) to give a light brown suspension. The reaction tube was sealed, and the reaction mixture was heated at 75 °C for 16 hours. After this time, reverse-phase HPLC shows approximately a 2:1 ratio of starting material to desired product. The reaction mixture was cooled to room temperature and partitioned between ethyl acetate and water. The organic phase was dried over Na2S04, filtered, and concentrated. The crude product was combined with crude fractions from small scale (60 mg) versions of the same reaction. This combined crude product was dissolved in CH2C12 and this mixture was concentrated over celite. The celite supported crude product was loaded onto a 80 gram SiliCycle column. Flash chromatography (10% ethyl acetate -hexanes) was used to isolate 2-cyclopropyl-4-nitrobenzonitrile.

Reference： [1]Current Patent Assignee: ROCHE HOLDING AG - WO2014/6066, 2014, A1 Location in patent: Paragraph 0246

14
[ 28163-00-0 ]
[ 191171-55-8 ]
[ 1617497-66-1 ]

Yield	Reaction Conditions	Operation in experiment
45%	With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate In 1,4-dioxane at 75 - 100℃; for 8.08333h; Inert atmosphere;	4.1.1.1 Suzuki coupling conditions General procedure: A solution of 2 M Na2CO3 (10 mL) was added under nitrogen to a 2-bromoaniline (10 mmol) in 60 mL dioxane. After 5 min stirring at 75 °C, Pd[P(C6H5)3]4 was added followed by (10 mmol) of a 2-cyanophenylboronic acid pinacol ester. The reaction was stirred 8 h at 100 °C. After cooling to rt the mixture was vacuum concentrated to half of its initial volume and extracted with CH2Cl2 (30 mL) and water (30 mL). The aqueous phase was extracted with CH2Cl2 (3×20 mL). The combined organic layers were washed with brine, dried over Na2SO4 and evaporated. The solid crystallized upon concentration.

Reference： [1]Nguyen, Phuhai; Oumata, Nassima; Soubigou, Flavie; Evrard, Justine; Desban, Nathalie; Lemoine, Pascale; Bouaziz, Serge; Blondel, Marc; Voisset, Cécile [European Journal of Medicinal Chemistry, 2014, vol. 82, p. 363 - 371]

15
[ 52301-88-9 ]
[ 28163-00-0 ]

Reference： [1]Journal of the Iranian Chemical Society,2015,vol. 12,p. 107 - 111

16
(2-chloro-4-nitrophenyl)methanamine [ No CAS ]
[ 28163-00-0 ]

Yield	Reaction Conditions	Operation in experiment
86%	With ammonium hydroxide; trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; ammonium bromide at 20℃; for 1.66667h; Green chemistry;

Reference： [1]Azarifar, Davood; Najminejad, Zohreh [Journal of the Iranian Chemical Society, 2015, vol. 12, # 1, p. 107 - 111]

17
[ 50274-95-8 ]
[ 28163-00-0 ]

Yield	Reaction Conditions	Operation in experiment
80%	With ammonium hydroxide; trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; ammonium bromide at 20℃; for 2h; Green chemistry;

Reference： [1]Azarifar, Davood; Najminejad, Zohreh [Journal of the Iranian Chemical Society, 2015, vol. 12, # 1, p. 107 - 111]

18
[ 42533-63-1 ]
[ 28163-00-0 ]

Yield	Reaction Conditions	Operation in experiment
85%	With ammonium hydroxide; trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; ammonium bromide at 20℃; for 1.5h; Green chemistry;

Reference： [1]Azarifar, Davood; Najminejad, Zohreh [Journal of the Iranian Chemical Society, 2015, vol. 12, # 1, p. 107 - 111]

19
[ 5568-33-2 ]
[ 28163-00-0 ]

Yield	Reaction Conditions	Operation in experiment
78%	With ammonium hydroxide; trans-3,5-dihydroperoxy-3,5-dimethyl-1,2-dioxolane; ammonium bromide at 20℃; for 0.833333h; Green chemistry;

Reference： [1]Azarifar, Davood; Najminejad, Zohreh [Journal of the Iranian Chemical Society, 2015, vol. 12, # 1, p. 107 - 111]

20
[ 28163-00-0 ]
[ 824-79-3 ]
2,4-bis(toluene-4-sulfonyl)benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
76%	With {(Pd{Fe(η5-C5H5)(η5-C5H3C(CH3)=NC6H4CH3-4)}(μ-Cl))2}; potassium carbonate In dimethyl sulfoxide at 110℃; for 12h; Inert atmosphere;	4.3. General procedure for the first palladium-catalyzed denitrated coupling of nitroarenes with aryl sulfinates General procedure: Under N2 atmosphere, a reaction vessel was charged with a mixture of sodium sulfinates 1 (0.6 mmol), nitroarenes 2 (0.3 mmol), palladacycle I (0.75 mol%) and K2CO3 (1.0 equiv) in DMSO (2 ml) at room temperature. After that, the mixture was heated to 110 °C and incubated in an oil bath for 12 h under N2 atmosphere. After the completion of the reaction, the reaction mixture was diluted with ethyl acetate and washed with brine three times. The combined organic solution was dried with Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by thin-layer chromatography on silica gel GF 254 (ethyl acetate/petroleum ether) to give the pure product.

Reference： [1]Tian, Heng; Cao, Aijuan; Qiao, Lijun; Yu, Ajuan; Chang, Junbiao; Wu, Yangjie [Tetrahedron, 2014, vol. 70, # 47, p. 9107 - 9112]

21
[ 28163-00-0 ]
[ 7251-09-4 ]

Reference： [1]Patent: CN110981800,2020,A

22
[ 28163-00-0 ]
[ 124-41-4 ]
[ 101084-96-2 ]

Yield	Reaction Conditions	Operation in experiment
83%	In methanol for 13h; Reflux;	1 S1, Synthesis of 4-nitro-2-methoxybenzonitrile (a) Take 181g of 4-nitro-2-chlorobenzonitrile and dissolve in 300g of methanol,Dissolve under heating and reflux, and drop 300g of 30% sodium methoxide solution into the system.After dripping after 1h, the reaction system keeps warm for 12h,After the reaction, most of the methanol was recovered under reduced pressure, and the residue was poured into ice water.A large amount of yellow solid is precipitated, filtered, and the filter cake is washed with water until neutral,The filter cake was recrystallized with isopropanol to obtain 147g of a yellow solid with a yield of 83%.

Reference： [1]Current Patent Assignee: ANHUI CHENGLIAN MEDICINE TECH - CN110981800, 2020, A Location in patent: Paragraph 0049-0050

23
[ 28163-00-0 ]
2-chloro-N'-hydroxy-4-nitrobenzene-1-carboximidamide [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
16%	With hydroxylamine hydrochloride; sodium hydroxide In ethanol; water for 6h; Reflux;	2-chloro-N'-hydroxy-4-nitrobenzene-1-carboximidamide (Scheme I, Step 1a): 2-chloro-4-nitrobenzonitrile (3.50 g, 19.20 mmol, 1 eq) was dissolved in 80 ml of ethanol and hydroxylamine hydrochloride (2.67 g, 38.4 mmol, 2 eq) was added followed by solution of NaOH (1.54 g, 38.4 mmol, 2 eq) in 20 ml of water. Reaction mixture was refluxed for 6 h (TLC control) and ethanol was evaporated in vacuo. 100 ml of water was added and reaction mixture was acidified with 1N HCl Precipitated solid was filtered and identified as byproduct 2-chloro-4-nitrobenzamide (1.80 g, 47%). Filtrate was extracted with AcOEt water layer was alkalized with NH3aq. Precipitated solid was filtered and purified by maceration from i-PrOH/hexane (1:3) resulting with 0.65 g of product as a white solid (16%).

Reference： [1]Current Patent Assignee: POLISH ACADEMY OF SCIENCES - EP2853532, 2020, B1 Location in patent: Paragraph 0063; 0064

24
[ 28163-00-0 ]
3-(2-chloro-4-nitrophenyl)-5-phenyl-1,2,4-oxadiazole [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: hydroxyamino hydrochloride; sodium hydroxide / ethanol; lithium hydroxide monohydrate / Reflux 2: potassium carbonate / toluene / 0.17 h / 170 °C / Microwave irradiation

Reference： [1]Bojarski, Andrzej J.; Brański, Piotr; Bugno, Ryszard; Burnat, Grzegorz; Chorobik, Paulina; Chruścicka, Barbara; Duszyńska, Beata; Kaczorowska, Katarzyna; Kozioł, Aneta; Paluchowska, Maria H.; Pilc, Andrzej; Stankiewicz, Anna; Wierońska, Joanna M. [Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, vol. 37, # 1, p. 211 - 225]

25
C₇H₃N₄O₂⁽¹⁺⁾*BF₄^(1-) [ No CAS ]
[ 28163-00-0 ]

Yield	Reaction Conditions	Operation in experiment
94%	With potassium chloride In glycerol at 22℃; for 4h;

Reference： [1]Antenucci, Achille; Bonomo, Matteo; Dughera, Stefano; Ghigo, Giovanni; Reviglio, Chiara [Molecules, 2022, vol. 27, # 6]

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P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere