* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Reference:
[1] Patent: US4703106, 1987, A,
[2] Patent: US4086221, 1978, A,
[3] Journal of Organic Chemistry, 1997, vol. 62, # 5, p. 1356 - 1362
[4] Tetrahedron, 2004, vol. 60, # 14, p. 3251 - 3259
[5] Patent: US5672584, 1997, A,
[6] Patent: US4693718, 1987, A,
[7] Patent: US4111924, 1978, A,
2
[ 26061-06-3 ]
[ 28782-78-7 ]
Yield
Reaction Conditions
Operation in experiment
92.4%
at 20℃; for 3 h;
Compound 9a (2.6 g, 10 mmol) in 50 ml methanol was treatedwith 1 M NaOH (30 ml), and stirred for 3 h at room temperature.The solvent was evaporated in vacuum and the residue wasadjusted to PH 2–3 with 1 M HCl. The mixture was extracted 3times by EtOAc. The organic phase was dried over Na2SO4. Evaporationof EtOAc provided compound 10a. White solid: yield 92.4percent,mp: 102–105 C.
Reference:
[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 5, p. 1413 - 1415
[2] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 11, p. 3055 - 3064
[3] Chemistry - An Asian Journal, 2017, vol. 12, # 12, p. 1326 - 1337
[4] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788,15
[5] European Journal of Organic Chemistry, 2012, # 29, p. 5774 - 5788
[6] Journal of Organic Chemistry, 2005, vol. 70, # 6, p. 2026 - 2032
3
[ 15761-38-3 ]
[ 28782-78-7 ]
Reference:
[1] Journal of Organic Chemistry, 1997, vol. 62, # 5, p. 1356 - 1362
[2] Pharmazie, 1982, vol. 37, # 6, p. 403 - 407
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 11, p. 3055 - 3064
[4] Chemistry - An Asian Journal, 2017, vol. 12, # 12, p. 1326 - 1337
4
[ 2483-49-0 ]
[ 56-40-6 ]
[ 28782-78-7 ]
Reference:
[1] Synlett, 2011, # 10, p. 1427 - 1430
Stage #1: glycine With calcium hydroxide In water at 20℃;
Stage #2: tert-butyloxycarbonyl-L-alanine p-nitrophenyl ester In N,N-dimethyl-formamide at 25℃; for 24h;