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Chemical Structure| 28955-71-7 Chemical Structure| 28955-71-7

Structure of 28955-71-7

Chemical Structure| 28955-71-7

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Product Details of [ 28955-71-7 ]

CAS No. :28955-71-7
Formula : C7H4N2O4
M.W : 180.12
SMILES Code : O=C1OC2=CC=CC([N+]([O-])=O)=C2N1
MDL No. :MFCD00460557

Safety of [ 28955-71-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338

Application In Synthesis of [ 28955-71-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 28955-71-7 ]

[ 28955-71-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 6665-98-1 ]
  • [ 530-62-1 ]
  • [ 28955-71-7 ]
YieldReaction ConditionsOperation in experiment
65% Example 24: 1-(4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-4-yl)urea (scheme 1) Preparation of 4-nitrobenzo[d]oxazol-2(3H)-one 4b (scheme 2) To <strong>[6665-98-1]2-hydroxy-6-nitrophenol</strong> 3b (2 g, 13.00 mmol) dissolved in THF (50 ml) was added in one portion DCI (1.5equiv., 19.6 mmol, 3.176 g) and the reaction was refluxed for 4 hours. (TLC AcOEt 1 / petroleum ether 1). The reaction was evaporated and the crude material was dissolved in HCL 2N and extracted 3 times with chloroform. The combined organic phases were washed with water, brine, dried over sodium sulfate and concentrated under vacuum. The crude solid was crystallized from ether giving 1,5g of a beige solid. Yield = 65% 1HNMR (DMSO, 200 MHz) delta 7.27 (1H, t, J = 7.8 Hz), 7.72 (1H, dd, J = 8.2 Hz, J' = 1 Hz), 7.93 (1H, dd, J = 8.4 Hz, J' = 0.6 Hz), 12.64 (1H, bs)
  • 2
  • [ 32315-10-9 ]
  • [ 603-87-2 ]
  • [ 28955-71-7 ]
YieldReaction ConditionsOperation in experiment
With triethylamine; In 1,2-dichloro-ethane; at 65 - 75℃;Large scale; The <strong>[603-87-2]2-amino-6-nitrophenol</strong> (III)-dichloroethane solution obtained by the second step of step 2), 1338.1 kg of triphosgene, 1369.0 kg of triethylamine was mixed, and the reaction was stirred at 65 to 75 C. To the end, a solution of 4-nitro-2-benzoxazolone (IV)-dichloroethane was obtained.
 

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