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Chemical Structure| 291514-03-9 Chemical Structure| 291514-03-9

Structure of 291514-03-9

Chemical Structure| 291514-03-9

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Product Details of [ 291514-03-9 ]

CAS No. :291514-03-9
Formula : C6H13NO2S
M.W : 163.24
SMILES Code : C=CCCCCS(=O)(N)=O

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Application In Synthesis of [ 291514-03-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 291514-03-9 ]

[ 291514-03-9 ] Synthesis Path-Downstream   1~2

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  • [ 53308-95-5 ]
  • [ 291514-03-9 ]
  • [ 1241589-41-2 ]
  • 2
  • [ 159622-10-3 ]
  • [ 291514-03-9 ]
  • [ 877069-65-3 ]
YieldReaction ConditionsOperation in experiment
Step 2. To a solution of acid (2.0 g, 8.8 mmol) in THF (30 (mL) stirred at rt was added CDI (1.6 g, 9.7 mmol). The reaction mixture was heated to 65 0C for 2 hr. A solution of sulfonamide (2.6 g, 15.3 mmol) in THF (5.0 mL) was added, followed by EPO <DP n="160"/>DBU (2.0 mL). After the addition, the reaction mixture was heated for 14 hr at 65 0C. The reaction mixture was cooled to rt and diluted with EtOAc, washed with saturated NHtCl, brine and dried over Na2SO4. The drying agent was filtered off and the solvent was evaporated. The residue was purified by Sipsi2 column (10-20- 35percent EtOAc in hexanes) to give the desired product (1.1 g). HNMR (300 MHz, CDCl3): 6 5.44-5.76 (m, 2H), 5.21 (d, IH), 5.06 (d, IH), 4.96-4.86 (m, 2H), 3.4-3.34 (m, 2H), 2.14-1.92 (m, 2H), 1.86-1.66 (m, 2H), 1.38 (s, 9H).
 

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