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Chemical Structure| 29310-88-1 Chemical Structure| 29310-88-1

Structure of 3-omega-Bromoacetylcoumarin
CAS No.: 29310-88-1

Chemical Structure| 29310-88-1

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Product Details of [ 29310-88-1 ]

CAS No. :29310-88-1
Formula : C11H7BrO3
M.W : 267.08
SMILES Code : O=C1C(C(CBr)=O)=CC2=C(O1)C=CC=C2
MDL No. :MFCD00488331
InChI Key :NTYOLVNSXVYRTJ-UHFFFAOYSA-N
Pubchem ID :2063461

Safety of [ 29310-88-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331-H341
Precautionary Statements:P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 29310-88-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 29310-88-1 ]

[ 29310-88-1 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 36822-11-4 ]
  • [ 29310-88-1 ]
  • [ 1233880-63-1 ]
  • 2
  • [ 3528-17-4 ]
  • [ 29310-88-1 ]
  • [ 100-52-7 ]
  • [ 17356-08-0 ]
  • 3-(7-phenyl-6,7-dihydrothiazolo[3,2-a]thiochromeno[4,3-d]pyrimidin-9-yl)-2H-chromen-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% General procedure: A mixture of thiochroman-4-one 1 (1 mmol), benzaldehyde 2(1 mmol), thiourea 3 (1 mmol) was stirred in presence of ionic liquid,[Bmim]HSO4 (1 mL) at 80 C for 20 min followed by the additionof 3-bromo-1-phenylpropan-1-one 4 (1 mmol) and theresulting mixture was further stirred at 80 C for 40-70 min. Theprogress of reaction was monitored by TLC. After completion ofthe reaction, the mixture was diluted with 20 mL of water,2 20 mL of EtOAc was added and shaken vigorously. The organiclayer was separated from the solution. The aqueous layer wasevaporated, the ionic liquid was dried at 60-70 C under vacuumand then reused. The results have shown that the [Bmim]HSO4ionic liquid could be reused at least for four times. The productwas purified by column chromatography on neutral alumina(100-200 mesh), eluted with a solvent system of ethyl acetate-hexane to afford the title compounds 5a-n.
  • 3
  • [ 3528-17-4 ]
  • [ 29310-88-1 ]
  • [ 104-88-1 ]
  • [ 17356-08-0 ]
  • 3-(7-(4-chlorophenyl)-6,7-dihydrothiazolo[3,2-a]thiochromeno[4,3-d]pyrimidin-9-yl)-2H-chromen-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% General procedure: A mixture of thiochroman-4-one 1 (1 mmol), benzaldehyde 2(1 mmol), thiourea 3 (1 mmol) was stirred in presence of ionic liquid,[Bmim]HSO4 (1 mL) at 80 C for 20 min followed by the additionof 3-bromo-1-phenylpropan-1-one 4 (1 mmol) and theresulting mixture was further stirred at 80 C for 40-70 min. Theprogress of reaction was monitored by TLC. After completion ofthe reaction, the mixture was diluted with 20 mL of water,2 20 mL of EtOAc was added and shaken vigorously. The organiclayer was separated from the solution. The aqueous layer wasevaporated, the ionic liquid was dried at 60-70 C under vacuumand then reused. The results have shown that the [Bmim]HSO4ionic liquid could be reused at least for four times. The productwas purified by column chromatography on neutral alumina(100-200 mesh), eluted with a solvent system of ethyl acetate-hexane to afford the title compounds 5a-n.
  • 4
  • [ 3528-17-4 ]
  • [ 29310-88-1 ]
  • [ 104-87-0 ]
  • [ 17356-08-0 ]
  • 3-((7-p-tolyl)-6,7-dihydrothiazolo[3,2-a]thiochromeno[4,3-d]pyrimidin-9-yl)-2H-chromen-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
86% General procedure: A mixture of thiochroman-4-one 1 (1 mmol), benzaldehyde 2(1 mmol), thiourea 3 (1 mmol) was stirred in presence of ionic liquid,[Bmim]HSO4 (1 mL) at 80 C for 20 min followed by the additionof 3-bromo-1-phenylpropan-1-one 4 (1 mmol) and theresulting mixture was further stirred at 80 C for 40-70 min. Theprogress of reaction was monitored by TLC. After completion ofthe reaction, the mixture was diluted with 20 mL of water,2 20 mL of EtOAc was added and shaken vigorously. The organiclayer was separated from the solution. The aqueous layer wasevaporated, the ionic liquid was dried at 60-70 C under vacuumand then reused. The results have shown that the [Bmim]HSO4ionic liquid could be reused at least for four times. The productwas purified by column chromatography on neutral alumina(100-200 mesh), eluted with a solvent system of ethyl acetate-hexane to afford the title compounds 5a-n.
  • 5
  • [ 3528-17-4 ]
  • [ 29310-88-1 ]
  • [ 99-61-6 ]
  • [ 17356-08-0 ]
  • 3-(7-(3-nitrophenyl)-6,7-dihydrothiazolo[3,2-a]thiochromeno[4,3-d]pyrimidin-9-yl)-2H-chromen-2-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
84% General procedure: A mixture of thiochroman-4-one 1 (1 mmol), benzaldehyde 2(1 mmol), thiourea 3 (1 mmol) was stirred in presence of ionic liquid,[Bmim]HSO4 (1 mL) at 80 C for 20 min followed by the additionof 3-bromo-1-phenylpropan-1-one 4 (1 mmol) and theresulting mixture was further stirred at 80 C for 40-70 min. Theprogress of reaction was monitored by TLC. After completion ofthe reaction, the mixture was diluted with 20 mL of water,2 20 mL of EtOAc was added and shaken vigorously. The organiclayer was separated from the solution. The aqueous layer wasevaporated, the ionic liquid was dried at 60-70 C under vacuumand then reused. The results have shown that the [Bmim]HSO4ionic liquid could be reused at least for four times. The productwas purified by column chromatography on neutral alumina(100-200 mesh), eluted with a solvent system of ethyl acetate-hexane to afford the title compounds 5a-n.
  • 6
  • [ 30748-47-1 ]
  • [ 29310-88-1 ]
  • [ 2231-57-4 ]
  • (E)-3-(2-(2-(1-(2-amino-4-methylthiazol-5-yl)ethylidene)hydrazinyl)-6H-1,3,4-thiadiazin-5-yl)-2H-chromen-2-one [ No CAS ]
  • 7
  • [ 30748-47-1 ]
  • [ 29310-88-1 ]
  • [ 79-19-6 ]
  • (E)-3-(2-(2-(1-(2-amino-4-methylthiazol-5-yl)ethylidene)hydrazinyl)thiazol-4-yl)-2H-chromen-2-one [ No CAS ]
 

Historical Records

Categories

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[ 29310-88-1 ]

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Related Parent Nucleus of
[ 29310-88-1 ]

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