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[ CAS No. 1446333-79-4 ]

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2D
Chemical Structure| 1446333-79-4
Chemical Structure| 1446333-79-4
Structure of 1446333-79-4 *Storage: {[proInfo.prStorage]}

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Product Details of [ 1446333-79-4 ]

CAS No. :1446333-79-4MDL No. :MFCD28397290
Formula : C11H6BrFO3 Boiling Point : -
Linear Structure Formula :-InChI Key :-
M.W :285.07Pubchem ID :-
Synonyms :

Computed Properties of [ 1446333-79-4 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 1446333-79-4 ]

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Precautionary Statements:UN#:
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Application In Synthesis of [ 1446333-79-4 ]

  • Downstream synthetic route of [ 1446333-79-4 ]

[ 1446333-79-4 ] Synthesis Path-Downstream   1~7

  • 1
  • [ 1211590-31-6 ]
  • [ 1446333-79-4 ]
  • [ 1446333-80-7 ]
YieldReaction ConditionsOperation in experiment
75% In ethanol; at 95.0℃; for 18.0h; Step A: A mixture of 3-(2-bromoacetyl)-7-fluoro-2H-chromen-2-one (500 mg, 1.75 mmol), <strong>[1211590-31-6]3-fluoro-5-methylpyridin-2-amine</strong> (240 mg, 1.9 mmol) and EtOH (3 mL) was heated at 95 C for 18 h. The reaction mixture was partitioned between CH2CI2 and aqueous K2C03. The organic layer was dried over MgS04, filtered, and concentrated under vacuum. The residue was triturated with 1 : 1 hexane/acetone, yielding 7-fluoro-3-(8-fluoro-6-methylimidazo[l,2-a]pyridin- 2-yl)-2H-chromen-2-one (412 mg, 75%) as an orange solid. 1H NMR (500 MHz, CDC13): delta 8.85 (1H, s), 8.50 (1H, d, J= 2.5 Hz), 7.77 (1H, m), 7.63 (1H, dd, J= 9Hz, 6 Hz), 7.11 (1H, dd, J= 9 Hz, 2 Hz), 7.07 (1H, td, J= 8.5 Hz, 2.5 Hz), 6.80 (1H, d, J= 6 Hz), 2.34 (3H, s).
75% In ethanol; at 95.0℃; for 18.0h; Step A: A mixture of 3-(2-bromoacetyl)-7-fluoro-2H-chromen-2-one (500 mg, 1.75 mmol), <strong>[1211590-31-6]3-fluoro-5-methylpyridin-2-amine</strong> (240 mg, 1.9 mmol) and EtOH (3 mL) was heated at 95 C. for 18 h. The reaction mixture was partitioned between CH2Cl2 and aqueous K2CO3. The organic layer was dried over MgSO4, filtered, and concentrated under vacuum. The residue was triturated with 1:1 hexane/acetone, yielding 7-fluoro-3-(8-fluoro-6-methylimidazo[1,2-a]pyridin-2-yl)-2H-chromen-2-one (412 mg, 75%) as an orange solid. 1H NMR (500 MHz, CDCl3): delta 8.85 (1H, s), 8.50 (1H, d, J=2.5 Hz), 7.77 (1H, m), 7.63 (1H, dd, J=9 Hz, 6 Hz), 7.11 (1H, dd, J=9 Hz, 2 Hz), 7.07 (1H, td, J=8.5 Hz, 2.5 Hz), 6.80 (1H, d, J=6 Hz), 2.34 (3H, s).
  • 2
  • [ 1211590-31-6 ]
  • [ 1446333-79-4 ]
  • [ 1446331-60-7 ]
  • 3
  • [ 91678-81-8 ]
  • [ 1446333-79-4 ]
  • 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-fluoro-2H-chromen-2-one hydrobromide [ No CAS ]
YieldReaction ConditionsOperation in experiment
90% In acetonitrile at 120℃; for 0.333333h; Sealed tube;
90% In acetonitrile at 120℃; for 0.333333h; Sealed tube; 43.A Step A: A mixture of 3-(2-bromoacetyl)-7-fluoro-2H-chromen-2-one (0.684 g, 2.4 mmol, prepared in Example 36, Part 2) and 3,5-dimethylpyrazin-2-amine (0.246 g, 2.0 mmol) in CH3CN (10 mL) was stirred at 120° C. in a sealed tube for 20 min. The mixture was cooled to room temperature and diluted with Et2O to produce a precipitate. The solid was collected by vacuum filtration, washed with Et2O and dried to give 3-(6,8-dimethylimidazo[1,2-a]pyrazin-2-yl)-7-fluoro-2H-chromen-2-one hydrobromide (0.7 g, 90%) as a tan solid. MS m/z 310.1 [M+H]+.
  • 4
  • [ 1446333-79-4 ]
  • [ 19842-07-0 ]
  • C18H13FN2O2 [ No CAS ]
  • 5
  • [ 5521-58-4 ]
  • [ 1446333-79-4 ]
  • C16H10FN3O2 [ No CAS ]
  • 6
  • [ 1446333-79-4 ]
  • [ 14667-55-1 ]
  • 1-(2-(7-fluoro-2-oxo-2H-chromen-3-yl)-2-oxoethyl)-2,3,5-trimethylpyrazin-1-ium bromide [ No CAS ]
  • 7
  • [ 50840-23-8 ]
  • [ 1446333-79-4 ]
  • 7-fluoro-3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)-2H-chromen-2-one hydrobromide [ No CAS ]
YieldReaction ConditionsOperation in experiment
42% In ethanol; at 95℃; for 16h; Step A: Following the procedure in Example 36, Part 3, 3-(2-bromoacetyl)-7-fluoro-2H-chromen-2-one (0.855 g, 3.0 mmol) and <strong>[50840-23-8]5-methylpyrimidin-2-amine</strong> (0.327 g, 3.0 mmol) in EtOH (6.0 mL) gave 7-fluoro-3-(6-methylimidazo[1,2-a]pyrimidin-2-yl)-2H-chromen-2-one hydrobromide (0.37 g, 42%) as a pale yellow solid. MS m/z 296.2 [M+H]+.
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