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Chemical Structure| 29538-77-0 Chemical Structure| 29538-77-0

Structure of 29538-77-0

Chemical Structure| 29538-77-0

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Product Details of [ 29538-77-0 ]

CAS No. :29538-77-0
Formula : C6H11ClO
M.W : 134.60
SMILES Code : O[C@H]1CC[C@H](Cl)CC1

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Application In Synthesis of [ 29538-77-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 29538-77-0 ]

[ 29538-77-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 29538-77-0 ]
  • [ 1306829-95-7 ]
  • trans-4-(3-bromo-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)cyclohexanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
70% With potassium carbonate; In N,N-dimethyl-formamide; at 150℃; for 12h; To a solution of 3-bromo-6-(methylthio)-li7-pyrazolo[3,4-d]pyrimidine (2.4 g, 9.7 mmol) and trans- 4-hydroxy-cyclohexyl chloride (2.60 g, 19.3 mmol) in DMF (20 mL) was added potassium carbonate (5.3 g, 38.6 mmol). The reaction mixture was heated at 150 C for 12 h, quenched with water, and extracted with EtOAc (3 x 10 mL). The combined organic phases were dried (Na2S04) and concentrated. The residue was purified by column chromatography with pre-packed silica gel disposable column to provide the desired product /ra//.s-4-(3-bromo-6-( ethylthio)- l //-pyrazolo[3,4-d]pyrimidin- l -yl)cyclohexanol (2.3 g, 70%) as a white solid.
 

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