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Chemical Structure| 299411-68-0 Chemical Structure| 299411-68-0

Structure of 299411-68-0

Chemical Structure| 299411-68-0

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Product Details of [ 299411-68-0 ]

CAS No. :299411-68-0
Formula : C13H12ClNO
M.W : 233.69
SMILES Code : OC1=CC2=C(C3=CC=CC=C31)[C@H](CCl)CN2

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Application In Synthesis of [ 299411-68-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 299411-68-0 ]

[ 299411-68-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 299411-68-0 ]
  • [ 2351-36-2 ]
  • naphthalene-2,6-diylbis[(S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indol-3-yl]methanone} [ No CAS ]
YieldReaction ConditionsOperation in experiment
40 mg With pyridine; In N,N-dimethyl-formamide; at 0 - 20℃; for 16h; General procedure: A hydrogen chloride solution (4 M in EtOAc, 5 mL) was added to 13 (70 mg, 0.21 mmol, 1.0 equiv.) at rt. After 3 h the reaction mixture was concentrated under reduced pressure and dried under high vacuum for 1 h. The residue was dissolved in DMF (5 mL) and cooled to 0 C. Subsequently, pyridine (50 mg, 51 μL, 0.63 mmol, 3.0 equiv.) and the trichloride of 7 (19 mg, 13 μL, 073 mmol, 0.35 equiv.) were added with stirring. The resulting mixture was allowed to warm to rt and stirring was continued for 20 h. Upon completion, the reaction was quenched with ice cold water (20 mL) and extracted with EtOAc (4 x 20 mL). The combined organic layers were washed (brine), dried (MgSO4) and concentrated under reduced pressure. The crude product was purified by flash column chromatography (EtOAc/PE, 1:1) to furnish the target molecule 15 as an orange solid (47 mg, 0.055 mmol, 79% yield).
 

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