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Chemical Structure| 299441-52-4 Chemical Structure| 299441-52-4

Structure of 299441-52-4

Chemical Structure| 299441-52-4

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Product Details of [ 299441-52-4 ]

CAS No. :299441-52-4
Formula : C16H13N3OS
M.W : 295.36
SMILES Code : O=C(NC1=CC=C(C2=CSC(N)=N2)C=C1)C3=CC=CC=C3
MDL No. :MFCD01119367

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Application In Synthesis of [ 299441-52-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 299441-52-4 ]

[ 299441-52-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 53137-27-2 ]
  • [ 299441-52-4 ]
  • N-(4-(4-benzamidophenyl)thiazol-2-yl)-2,4-dimethylthiazole-5-carboxamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
48% With pyridine; propylphosphonic anhydride; In ethyl acetate; acetonitrile; at 48.5℃; for 96h;Sealed tube; To a suspension of N-(4-(2-aminothiazol-4-yl)phenyl)benzamide (0.041 g, 0.138 mmol) and <strong>[53137-27-2]2,4-dimethylthiazole-5-carboxylic acid</strong> (0.024 g, 0.152 mmol), and pyridine (0.01 mL, 0.623 mmol) in acetonitrile (1.5 mL) in a sealed tube was added propylphosphonic anhydride solution (50 wt % in ethyl acetate, 0.29 mL, 0.485 mmol). The sealed tube was heated to 48.5 C. for 4 days. After cooling, the mixture was quenched with water (10 mL) and extracted with 8:2 dichloromethane/isopropanol (2*25 mL) followed by washing once with sat. NaHCO3 (100 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The residue was purified by precipitating in dichloromethane and filtration to give N-(4-(4-benzamidophenyl)thiazol-2-yl)-2,4-dimethylthiazole-5-carboxamide (0.029 g, 48%) as a beige solid. 1H NMR (400 MHz, DMSO-d): delta 10.34 (s, 1H), 7.96 (d, 2H, J=7.2 Hz), 7.89 (m, 4H), 7.57 (m, 4H), 2.67 (s, 3H), 2.62 (s, 3H). MS (ESI): Calcd. for C22H18N4O2S2: 434, found 435 (M+1)+.
 

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