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Chemical Structure| 928038-44-2 Chemical Structure| 928038-44-2
Chemical Structure| 928038-44-2

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Product Details of 3-Azetidinemethanol HCl

CAS No. :928038-44-2
Formula : C4H10ClNO
M.W : 123.58
SMILES Code : Cl.N1CC(C1)CO
MDL No. :MFCD09743446
InChI Key :AQUVQGSNKVDBBF-UHFFFAOYSA-N
Pubchem ID :24801400

Safety of 3-Azetidinemethanol HCl

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P302+P352-P337+P313-P304+P340-P312-P280-P332+P313

Application In Synthesis of 3-Azetidinemethanol HCl

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 928038-44-2 ]

[ 928038-44-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 928038-44-2 ]
  • [ 103962-05-6 ]
  • 1-(4-trifluoromethoxyphenyl)azetidine-3-methanol [ No CAS ]
YieldReaction ConditionsOperation in experiment
44% With copper(l) iodide; caesium carbonate; L-proline; In dimethyl sulfoxide; at 90℃; for 18h;Inert atmosphere; 1-iodo-4-trifluoromethoxybenzene (288mg, 1.00 mmol), 3-methoxyazetidine hydrochloride (82mg, 0.66mmol), cuprous iodide (25mg, 0.13 mmol), L-proline (30.4 mg, 0.26 mmol) and cesium carbonate (538mg, 1.65 mmol)were dissolved in 10ml of DMSO and heated to 90C and reacted for 18h under nitrogen protection. After the reactionwas completed, the reaction solution was cooled to room temperature, diluted with ethyl acetate, washed with waterand saturated sodium chloride aqueous solution in turn, dried over anhydrous sodium sulfate, filtered, concentratedunder reduced pressure, and then subjected to silica gel column chromatography to obtain 71mg of 1-(4-trifluoromethoxyphenyl)azetidine-3-methanol as a brown solid, yield 44%; 1H NMR (400 MHz, DMSO) δ 7.13 (d, J = 8.8 Hz, 2H),6.43 (d, J = 8.9 Hz, 2H), 4.75 (t, J = 5.3 Hz, 1H), 3.83 (t, J = 7.6 Hz, 2H), 3.60 - 3.51 (m, 4H), 2.80-2.72 (m, 1H).
 

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