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Chemical Structure| 31224-43-8 Chemical Structure| 31224-43-8
Chemical Structure| 31224-43-8

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Product Details of 3-Fluoropyridine-2-carbaldehyde

CAS No. :31224-43-8
Formula : C6H4FNO
M.W : 125.10
SMILES Code : O=CC1=NC=CC=C1F
MDL No. :MFCD07781234
InChI Key :OZIMPUNGBUYCSP-UHFFFAOYSA-N
Pubchem ID :11344017

Safety of 3-Fluoropyridine-2-carbaldehyde

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3-Fluoropyridine-2-carbaldehyde

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 31224-43-8 ]

[ 31224-43-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 31224-43-8 ]
  • ammonium chloride [ No CAS ]
  • [ 31181-79-0 ]
YieldReaction ConditionsOperation in experiment
3.78 g (93%) With sodium borohydrid; In ethanol; ethyl acetate; 2-Hydroxymethyl-3-fluoropyridine A solution of 2-formyl-3-fluoropyridine (4.0 g, 32 mmol) and sodium borohydride (309 mg, 8 mmol) in absolute ethanol (40 mL) was stirred at 0° C. for 15 minutes and at room temperature for 1 hour. The reaction was quenched with saturated aqueous ammonium chloride (5 mL) and filtered through diatomaceous earth to remove solids. The filtrate was evaporated and the resultant white solid was dissolved in ethyl acetate and water. The aqueous layer was extracted with ethyl acetate (5*30 mL) and the combined extracts were dried over anhydrous sodium sulfate. Solvent removal provided 3.78 g (93percent) of the titled product as a pale yellow oil: IR (CHCl3, cm-1) 3607, 3439, 3019, 1607, 1576, 1451, 1416, 1312, 1257, 1218, 1209, 1167, 1105, 1053, 857, 803; 1 H NMR (300 MHz, CDCl3) delta8.38 (m, 1H), 7.39 (m, 1H), 7.26 (m, 1H), 4.83 (s, 2H), 3.73 (br s, 1H); MS (FD) m/e 127 (M+);
  • 2
  • [ 22280-60-0 ]
  • [ 31224-43-8 ]
  • 3
  • [ 31224-43-8 ]
  • [ 1330624-42-4 ]
 

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