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Chemical Structure| 30005-58-4 Chemical Structure| 30005-58-4

Structure of 30005-58-4

Chemical Structure| 30005-58-4

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Product Details of [ 30005-58-4 ]

CAS No. :30005-58-4
Formula : C11H12ClN
M.W : 193.67
SMILES Code : ClC1=CC=C(C2=CCNCC2)C=C1

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Application In Synthesis of [ 30005-58-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30005-58-4 ]

[ 30005-58-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 51304-61-1 ]
  • [ 30005-58-4 ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide; In water; The 4- (4-CHLOROPHENYL)-1, 2, 3, 6-tetrahydropyridine hydrochloride (2.52 g, 10.9 mmol) was treated with 1N NAOH (20 mL); and aqueous mixture was extracted with CH2C12 (20 mL). The organic layer was separated, dried over NA2S04, and filtered. The solvent was removed under reduced pressure. To a solution OF 4- (4-CHLOROPHENYL)-1, 2,3, 6-TETRAHYDROPYRIDINE (2.07 g, 10.7 mmol) in acetone (25 mL) was added 1,3-propane sultone (1.41 g, 11.8 MMOL). The mixture was stirred at reflux for 2h. The reaction mixture was cooled to room temperature. The solid was collected by filtration, washed with acetone (2 x 20 mL) and dried in vacuo. The product was suspended in 50% MEOH/ACETONE (75 mL). The suspension was stirres at reflux for 5 minutes before 25 mL of cold acetone was added. The solid material was filtered and washed with acetone (2 x 25 mL). This allowed the isolation of compound J, 1. 48 g (44%).
 

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