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Chemical Structure| 301180-04-1 Chemical Structure| 301180-04-1

Structure of 301180-04-1

Chemical Structure| 301180-04-1

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Product Details of [ 301180-04-1 ]

CAS No. :301180-04-1
Formula : C18H25NO4
M.W : 319.40
SMILES Code : O=C(C1CN(C(OCC2=CC=CC=C2)=O)CCC1)OC(C)(C)C
MDL No. :MFCD04038570

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Application In Synthesis of [ 301180-04-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 301180-04-1 ]

[ 301180-04-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 98946-18-0 ]
  • [ 78190-11-1 ]
  • [ 301180-04-1 ]
YieldReaction ConditionsOperation in experiment
96% With boron trifluoride diethyl etherate; In tetrahydrofuran; at 20℃; for 18h; [1247] A solution of Example A (18 g, 62 mmol). in THF (250 mL, 0.25 M) was treated with trichloroacetimidate (28 mL, 155 mmol) and BF3.Et2O (18 mL, 1 mL/g) at ambient temperature. After 18 h the reaction mixture was quenched with solid NaHCO3 followed by water and stirred vigorously. Then the solvent was removed, and partitioned with ethyl acetate (250 mL). The organic layer was separated and washed with brine (3×80 mL), dried (Na2SO4) and evaporated to dryness under reduced pressure to obtain the crude product. The title compound (19.2 g, 96%) was obtained by flash chromatography on silica gel eluting with 20% acetone:hexane. MS (ESI) m/e 320 (M+H)+.
 

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