Alternatived Products of [ 302341-61-3 ]
Product Details of [ 302341-61-3 ]
CAS No. : | 302341-61-3 |
MDL No. : | MFCD24466038 |
Formula : |
C12H15N3O2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
233.27
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Pubchem ID : | - |
Synonyms : |
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Safety of [ 302341-61-3 ]
Application In Synthesis of [ 302341-61-3 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 302341-61-3 ]
- 1
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[ 17874-78-1 ]
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[ 302341-61-3 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 7 steps
1: SOCl2; DMF / 1,2-dichloro-ethane / Heating
2: NH3 / tetrahydrofuran / -10 °C
3: (CF3CO)2); i-Pr2NEt / CH2Cl2 / 20 °C
4: NH3 / ethanol / -10 °C
5: 93 percent / aq. HCl; H2 / Pd/C / propan-1-ol / 6 h / 1500.12 Torr
6: 90 percent / aq. NaOH / methanol / 50 - 55 °C
7: Et3N / CH2Cl2; trifluoroacetic acid / 1 h / 20 - 25 °C |
|
Reference:
[1]Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
[Synthesis, 2004, # 14, p. 2367 - 2375]
- 2
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[ 41051-03-0 ]
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[ 302341-61-3 ]
Yield | Reaction Conditions | Operation in experiment |
|
Multi-step reaction with 4 steps
1: NH3 / ethanol / -10 °C
2: 93 percent / aq. HCl; H2 / Pd/C / propan-1-ol / 6 h / 1500.12 Torr
3: 90 percent / aq. NaOH / methanol / 50 - 55 °C
4: Et3N / CH2Cl2; trifluoroacetic acid / 1 h / 20 - 25 °C |
|
Reference:
[1]Bernard, Harald; Buelow, Gerd; Lange, Udo E. W.; Mack, Helmut; Pfeiffer, Thomas; Schaefer, Bernd; Seitz, Werner; Zierke, Thomas
[Synthesis, 2004, # 14, p. 2367 - 2375]
- 3
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[ 557-21-1 ]
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[ 285119-72-4 ]
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[ 302341-61-3 ]
Yield | Reaction Conditions | Operation in experiment |
90% |
In N,N-dimethyl-formamide at 70℃; |
55
Preparation 55; 5-Aminomethyl-2-(piperidin-l-ylmethyl)-pyridine; S-ffert-Butoxycarbonylamino-methvD--cyano-pyridine; Under a nitrogen atmosphere, add 3-(tert-butoxycarbonylamino-methyl)-6-chloropyridine (13.1 g, 54 mmol), zinc cyanide (9.5 g, 81 mmol), tris(dibenzylideneacetone)dipalladium(0) (494 mg, 0.54 mmol), and dppf (550 mg, 0.81 mmol) to DMF (130 mL). Heat the mixture at 700C overnight. Cool the mixture to room temperature and dilute with water and EtOAc, Separate the layers, and extract the aqueous layer with EtOAc. Wash the combined organic extracts with water and brine. Dry the organic solution over Na2SO4, filter, and concentrate in vacuo. Purify by chromatography on silica gel (500 g) eluting with hexane/EtOAc (1 :0 to 7:3 gradient) to provide the desired intermediate as a white solid (11.3 g, 90%). MS (ES+) m/z: 234 (M+H)+. |
- 4
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[ 58553-48-3 ]
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[ 302341-61-3 ]
- 5
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[ 89809-65-4 ]
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[ 302341-61-3 ]