[ CAS No. 30290-78-9 ] {[proInfo.proName]}

Name: 30290-78-9|4-Phenyl-1,2,3,4-tetrahydroquinoline|95%
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Quality Control of [ 30290-78-9 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 30290-78-9 ]

SDS Specification

Alternatived Products of [ 30290-78-9 ]

Product Details of [ 30290-78-9 ]

CAS No. :	30290-78-9	MDL No. :	MFCD20331711
Formula :	C₁₅H₁₅N	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	YUEVNAMKBJHWDG-UHFFFAOYSA-N
M.W :	209.29	Pubchem ID :	12209396
Synonyms :

Calculated chemistry of [ 30290-78-9 ]

Physicochemical Properties

Num. heavy atoms :	16
Num. arom. heavy atoms :	12
Fraction Csp3 :	0.2
Num. rotatable bonds :	1
Num. H-bond acceptors :	0.0
Num. H-bond donors :	1.0
Molar Refractivity :	70.83
TPSA :	12.03 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	Yes
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	Yes
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.91 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.44
Log Po/w (XLOGP3) :	3.75
Log Po/w (WLOGP) :	3.06
Log Po/w (MLOGP) :	3.47
Log Po/w (SILICOS-IT) :	3.61
Consensus Log Po/w :	3.27

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.99
Solubility :	0.0215 mg/ml ; 0.000103 mol/l
Class :	Soluble
Log S (Ali) :	-3.7
Solubility :	0.0422 mg/ml ; 0.000202 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-5.57
Solubility :	0.000562 mg/ml ; 0.00000269 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	2.0
Synthetic accessibility :	2.37

Safety of [ 30290-78-9 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 30290-78-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 30290-78-9 ]

[ 30290-78-9 ] Synthesis Path-Downstream 1~33

1
[ 605-03-8 ]
[ 64-17-5 ]
[ 30290-78-9 ]

Reference： [1]Patent: DE79385,
Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 4,p. 1142

2
[ 605-03-8 ]
[ 30290-78-9 ]

Reference： [1]Chemische Berichte,1895,vol. 28,p. 1042
[2]Pharmaceutical Chemistry Journal,1980,vol. 14,p. 532 - 538
Khimiko-Farmatsevticheskii Zhurnal,1980,vol. 14,p. 38 - 43
[3]Patent: DE79385,
Fortschr. Teerfarbenfabr. Verw. Industriezweige,vol. 4,p. 1142

3
[ 30290-78-9 ]
[ 108-24-7 ]
1-acetyl-4-phenyl-1,2,3,4-tetrahydro-quinoline [ No CAS ]

Reference： [1]Koenigs; Meimberg [Chemische Berichte, 1895, vol. 28, p. 1042]

4
[ 30290-78-9 ]
[ 74-88-4 ]
[ 27623-83-2 ]

Reference： [1]Koenigs; Meimberg [Chemische Berichte, 1895, vol. 28, p. 1042]

5
[ 30290-78-9 ]
1-nitroso-4-phenyl-1,2,3,4-tetrahydro-quinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium nitrite in saurer Loesung;
	With sodium nitrite in saurer Loesung;

Reference： [1]Koenigs; Meimberg [Chemische Berichte, 1895, vol. 28, p. 1042]
[2]Current Patent Assignee: Hoechster Farbw. - DE79385, 1800, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 1142][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 1142]

6
[ 30290-78-9 ]
[ 111663-92-4 ]

Yield	Reaction Conditions	Operation in experiment
	Benzoylieren, nach Schotten-Baumann;

Reference： [1]Koenigs; Meimberg [Chemische Berichte, 1895, vol. 28, p. 1042]

7
[ 4888-33-9 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	With ethanol; sodium
	With diisobutylaluminium hydride In toluene for 5h; Reflux;

Reference： [1]Perold; v.Reiche [Journal of the American Chemical Society, 1957, vol. 79, p. 465]
[2]Chisholm, David R.; Zhou, Garr-Layy; Pohl, Ehmke; Valentine, Roy; Whiting, Andrew [Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 1851 - 1862]

8
[ 30290-78-9 ]
[ 79-04-9 ]
[ 76061-90-0 ]

Yield	Reaction Conditions	Operation in experiment
84.3%	for 0.666667h; Heating;

Reference： [1]Shvedov, V. I.; Vasil'eva, V. F.; Korsakova, I. Ya.; Galitsina, V. A.; Medvedev, B. A.; et al. [Pharmaceutical Chemistry Journal, 1980, vol. 14, # 8, p. 532 - 538][Khimiko-Farmatsevticheskii Zhurnal, 1980, vol. 14, # 8, p. 38 - 43]

9
[ 100-42-5 ]
[ 622-79-7 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	With trifluorormethanesulfonic acid 1.) C₆H₆, from 0 deg C to RT, 10 min, 2.) benzene, RT, 1 h; Yield given. Multistep reaction;

Reference： [1]Pearson, William H.; Fang, Wen-Kui [Israel Journal of Chemistry, 1997, vol. 37, # 1, p. 39 - 46]

11
1-acetyl-4-phenyl-1,2,3,4-tetrahydro-quinoline [ No CAS ]
[ 30290-78-9 ]

Reference： [1]Koenigs; Meimberg [Chemische Berichte, 1895, vol. 28, # 1042, p. 1043]

12
[ 7647-01-0 ]
[ 605-03-8 ]
[ 64-17-5 ]
[ 7732-18-5 ]
[ 30290-78-9 ]

13
[ 87374-48-9 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
7 % Chromat.	In acetonitrile at 20℃; for 0.5h; Photolysis;

Reference： [1]Leo, Edgar A.; Domingo, Luis R.; Miranda, Miguel A.; Tormos, Rosa [Journal of Organic Chemistry, 2006, vol. 71, # 12, p. 4439 - 4444]

14
[ 30290-78-9 ]
[ 76061-98-8 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 84.3 percent / 0.67 h / Heating 2: 62 percent / ethanol / 2 h

15
[ 30290-78-9 ]
[ 76061-83-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: 84.3 percent / 0.67 h / Heating 2: urotropine, NaI / ethanol / 24 h / Ambient temperature 3: 84 percent / ethanol / 0.67 h / Heating

16
[ 30290-78-9 ]
[ 695143-00-1 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: 84.3 percent / 0.67 h / Heating 2: urotropine, NaI / ethanol / 24 h / Ambient temperature

17
[ 2983-48-4 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: conc. aq. HCl / butan-1-ol / 9 h 2: Na, n-butanol / Heating

18
[ 30290-78-9 ]
4-phenyl-3,4-dihydro-2<i>H</i>-quinolin-6-one oxime [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: sodium nitrite / in saurer Loesung 2: glacial acetic acid; alcoholic hydrochloric acid / 30 °C
	Multi-step reaction with 2 steps 1: sodium nitrite / in saurer Loesung 2: hydrogenchloride; acetic acid / 30 °C

19
[ 3056-73-3 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: concentrated aqueous hydriodic acid 2: ethanol; sodium
	Multi-step reaction with 2 steps 1: Polyphosphoric acid / 0.17 h / 120 °C 2: diisobutylaluminium hydride / toluene / 5 h / Reflux

20
[ 14371-10-9 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C 2: polyphosphoric acid / 100 °C / Inert atmosphere
	Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 15 h / Inert atmosphere 2: polyphosphoric acid / 6 h / 100 °C

Reference： [1]Rao Lingam, V.S. Prasada; Thomas, Abraham; Mukkanti, Khagga; Gopalan, Balasubramanian [Synthetic Communications, 2011, vol. 41, # 12, p. 1809 - 1828]
[2]Jung, Dahyeon; Kim, Min Hye; Kim, Jinho [Organic Letters, 2016, vol. 18, # 24, p. 6300 - 6303]

21
[ 92573-86-9 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
71%	With polyphosphoric acid at 100℃; Inert atmosphere;
	With polyphosphoric acid at 100℃; for 6h;

Reference： [1]Location in patent: experimental part Rao Lingam, V.S. Prasada; Thomas, Abraham; Mukkanti, Khagga; Gopalan, Balasubramanian [Synthetic Communications, 2011, vol. 41, # 12, p. 1809 - 1828]
[2]Jung, Dahyeon; Kim, Min Hye; Kim, Jinho [Organic Letters, 2016, vol. 18, # 24, p. 6300 - 6303]

22
[ 62-53-3 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 2 steps 1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane / 20 °C 2: polyphosphoric acid / 100 °C / Inert atmosphere
	Multi-step reaction with 3 steps 1.1: dichloromethane / 0.5 h 1.2: 4 h / 20 °C 2.1: Polyphosphoric acid / 0.17 h / 120 °C 3.1: diisobutylaluminium hydride / toluene / 5 h / Reflux
	Multi-step reaction with 2 steps 1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 15 h / Inert atmosphere 2: polyphosphoric acid / 6 h / 100 °C

Reference： [1]Rao Lingam, V.S. Prasada; Thomas, Abraham; Mukkanti, Khagga; Gopalan, Balasubramanian [Synthetic Communications, 2011, vol. 41, # 12, p. 1809 - 1828]
[2]Chisholm, David R.; Zhou, Garr-Layy; Pohl, Ehmke; Valentine, Roy; Whiting, Andrew [Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 1851 - 1862]
[3]Jung, Dahyeon; Kim, Min Hye; Kim, Jinho [Organic Letters, 2016, vol. 18, # 24, p. 6300 - 6303]

23
[ 30290-78-9 ]
[ 605-03-8 ]

Yield	Reaction Conditions	Operation in experiment
92%	With diethylazodicarboxylate; In chloroform; toluene; at 20℃; for 12h;	General procedure: To a 10 mL round bottom flask equipped with a magnetic stir bar, 1,2,3,4-tetrahydroquinoline (0.5 mmol), DEAD solution 40 wt% in toluene (2.2 eq, 1.1 mmol, 0.5 mL), and CHCl3 (1.0 mL) was added. The reaction mixture was stirred at room temperature for 12 h. The mixture was concentrated on rotary evaporator. The residue was purified by column chromatography with EtOAc:hexane (1:5) to give quinolines. In case of 2f and 2m, the product spot was close to the spot of the remained DEAD. To eliminate the remained DEAD, 1 equivalent of PPh3 was added after the reaction and the reaction mixture was stirred.[19] After 10 min, the reaction mixture was concentrated on rotary evaporator. The residue was purified by column chromatography with CHCl3:hexane (1:1) to give quinolines.
70%	With 4-tert-Butylcatechol; oxygen; In water; at 20℃; for 20h;Green chemistry;	General procedure: N-heterocycle substrate (0.2 mmol), Na-AMO (20 mg, 10 mol%), catechol Q-2 (3.3 mg, 0.02 mmol) was added into a reaction tube. The reaction tube was filled and protected with oxygen using a O2 balloon, then H2O was added into the reaction tube with a syringe. The reaction was allowed to react at room temperature for 20 h. After completion of reaction, the resulting mixture was filtered, washed with EtOAc and extracted by EtOAc. The organic phases were combined, washed with brine and dried with Na2SO4. Next, organic solution was concentrated under reduced vacuum to give the crude product. Finally, the product was purified by silica gel chromatography to yield the pure product.

Reference： [1]Organic Letters,2016,vol. 18,p. 6300 - 6303
[2]Journal of the American Chemical Society,2014,vol. 136,p. 11910 - 11913
[3]Synthetic Communications,2018,vol. 48,p. 1291 - 1298
[4]Tetrahedron Letters,2020,vol. 61
[5]Organic Letters,2018,vol. 20,p. 6436 - 6439
[6]Catalysis science and technology,2020,vol. 10,p. 360 - 371

24
[ 100-42-5 ]
[ 50-00-0 ]
[ 30290-78-9 ]
copper(II) tetrafluroborate hexahydrate [ No CAS ]
C₄₈H₃₈N₂⁽²⁺⁾*2BF₄^(1-) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87%	In nitromethane at 100℃; for 24h; Sealed tube; Inert atmosphere; Schlenk technique;

Reference： [1]Chen, Wei-Chen; Gandeepan, Parthasarathy; Tsai, Chia-Hung; Luo, Ching-Zong; Rajamalli, Pachaiyappan; Cheng, Chien-Hong [RSC Advances, 2016, vol. 6, # 68, p. 63390 - 63397]

25
[ 30290-78-9 ]
[ 605-03-8 ]
C₃₀H₂₀N₂ [ No CAS ]

Reference： [1]RSC Advances,2016,vol. 6,p. 63390 - 63397

26
[ 102-92-1 ]
[ 30290-78-9 ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1.1: dichloromethane / 0.5 h 1.2: 4 h / 20 °C 2.1: Polyphosphoric acid / 0.17 h / 120 °C 3.1: diisobutylaluminium hydride / toluene / 5 h / Reflux

Reference： [1]Chisholm, David R.; Zhou, Garr-Layy; Pohl, Ehmke; Valentine, Roy; Whiting, Andrew [Beilstein Journal of Organic Chemistry, 2016, vol. 12, p. 1851 - 1862]

27
[ 30290-78-9 ]
4-phenyl-[6]quinolylamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	Multi-step reaction with 3 steps 1: sodium nitrite / in saurer Loesung 2: hydrogenchloride; acetic acid / 30 °C

Reference： [1]Current Patent Assignee: Hoechster Farbw. - DE79385, 1800, C [Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 1142][Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 4, p. 1142]

28
[ 30290-78-9 ]
[ 586-96-9 ]
2-((1H-indol-3-yl)(phenyl)methyl)aniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
57%	With 4-nitro-benzoic acid In toluene for 18h; Inert atmosphere;

Reference： [1]Roy, Subhra Kanti; Purkait, Anisha; Aziz, Sk Md Tarik; Jana, Chandan K. [Chemical Communications, 2020, vol. 56, # 21, p. 3167 - 3170]

29
[ 30290-78-9 ]
[ 932-98-9 ]
2-((5-chloro-1H-indol-3-yl)(phenyl)methyl)aniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
51%	With 4-nitro-benzoic acid In toluene for 18h; Inert atmosphere;

Reference： [1]Roy, Subhra Kanti; Purkait, Anisha; Aziz, Sk Md Tarik; Jana, Chandan K. [Chemical Communications, 2020, vol. 56, # 21, p. 3167 - 3170]

30
[ 30290-78-9 ]
[ 3623-23-2 ]
2-((5-bromo-1H-indol-3-yl)(phenyl)methyl)aniline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
50%	With 4-nitro-benzoic acid In toluene for 18h; Inert atmosphere;

Reference： [1]Roy, Subhra Kanti; Purkait, Anisha; Aziz, Sk Md Tarik; Jana, Chandan K. [Chemical Communications, 2020, vol. 56, # 21, p. 3167 - 3170]

31
[ 30290-78-9 ]
[ 555-16-8 ]
[ 126-81-8 ]
10,10-dimethyl-7-(4-nitrophenyl)-3-phenyl-2,3,7,9,10,11-hexahydro-1H,8H-pyrido[3,2,1-de]acridin-8-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
60%	With 2,4 dichlorobenzoic acid In toluene at 130℃; for 2h; Microwave irradiation; diastereoselective reaction;

Reference： [1]Jana, Chandan K.; Mandal, Sumana; Saha, Subhajit [Organic Letters, 2020]

32
[ 50-00-0 ]
[ 30290-78-9 ]
propargyl ether mycophenolate [ No CAS ]
mycophenoyl methyl ester-7-(butynyloxy-(4-phenyltetrahydroquinoline)) [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
72%	With copper(l) iodide In 1,4-dioxane at 120℃; for 1h;	1.4 General procedure for synthesis of new propargylamine mycophenolate derivatives (6a-6aa). General procedure: To the solution of propargylether mycophenolate 3 (100 mg, 0.2685 mmol) in dioxane (1.5mL) was added CuI (0.5 equiv.), HCHO (5.0 equiv) and amine (1.1 equiv). The resultingsolution was stirred at 120 oC for 1 hour. After TLC indicated that the reaction was complete.The reaction mixture was then filtered through a celite and eluted with EtOAc (30.0 mL). Thefiltrate was concentrated in vacuo, the crude residue was then purified by flash columnchromatography.

Reference： [1]Silalai, Patamawadee; Pruksakorn, Dumnoensun; Chairoungdua, Arthit; Suksen, Kanoknetr; Saeeng, Rungnapha [Bioorganic and Medicinal Chemistry Letters, 2021, vol. 45]

33
[ 121194-51-2 ]
[ 605-03-8 ]
[ 30290-78-9 ]
4‐phenyl‐1,2‐dihydroquinoline [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
1: 25% 2: 56% 3: 7%	With Echavarren's catalyst In dichloromethane at 80℃; for 0.5h; Sealed tube; Inert atmosphere;

Reference： [1]Arcadi, Antonio; Calcaterra, Andrea; Fabrizi, Giancarlo; Fochetti, Andrea; Goggiamani, Antonella; Iazzetti, Antonia; Marrone, Federico; Marsicano, Vincenzo; Mazzoccanti, Giulia; Serraiocco, Andrea [Molecules, 2021, vol. 26, # 11]

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 30290-78-9 ] {[proInfo.proName]}

Quality Control of [ 30290-78-9 ]

Related Doc. of [ 30290-78-9 ]

Product Details of [ 30290-78-9 ]

Calculated chemistry of [ 30290-78-9 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 30290-78-9 ]

Application In Synthesis of [ 30290-78-9 ]

[ 30290-78-9 ] Synthesis Path-Downstream 1~33

Related Parent Nucleus of [ 30290-78-9 ]

Tetrahydroquinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Parent Nucleus of
[ 30290-78-9 ]