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CAS No. : | 30354-18-8 | MDL No. : | MFCD00011809 |
Formula : | C3H8ClN | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | ZJTROANVDZIEGB-UHFFFAOYSA-M |
M.W : | 93.56 | Pubchem ID : | 11051579 |
Synonyms : |
|
Signal Word: | Danger | Class: | 4.1 |
Precautionary Statements: | P210-P261-P305+P351+P338 | UN#: | 1325 |
Hazard Statements: | H228-H315-H319-H335 | Packing Group: | Ⅲ |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | at 20℃; | General procedure: Synthesis Procedure C. For the title compounds cannot to be obtained with Procedure A and Procedure B, the iminium salts of the amines (Mannich Reagents) were used [29]. A suspension of substrate (1 mmol) and iminium salts of amine (1 mmol) was stirred in acetonitrile or toluene at room temperature (Scheme 2). Precipitated crude product was recrystallized from appropriate solvents to yield the desired Mannich bases. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
(i) HCl, CHCl3, (ii) /BRN= 1736289/, (iii) aq. NaClO4; Multistep reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | In acetonitrile for 72h; Ambient temperature; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride In N,N-dimethyl-formamide 1) 100 deg C, 2.5 h, 2) room temperature, 3 d; Yield given; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | With potassium carbonate In N,N-dimethyl-formamide at 60℃; for 3h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
3.5 g | With hydrogenchloride In 1,2-dimethoxyethane; N,N-dimethyl-formamide for 2.5h; heating on a steam bath; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | In acetonitrile at 45 - 50℃; for 24h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | In acetonitrile for 2h; Ambient temperature; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | In acetonitrile at 110℃; Inert atmosphere; | |
76% | ||
57% | In acetonitrile Reflux; |
57% | In acetonitrile for 3 - 4h; Reflux; Schlenk technique; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | Stage #1: N-cyclohexylacetamide With trichlorophosphate In diethyl ether at 20℃; for 2h; Stage #2: N,N-dimethyl(methylene)ammonium chloride In diethyl ether at 20℃; Stage #3: With perchloric acid In isopropyl alcohol at 0℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
31% | Stage #1: N-(3,4-dichlorophenyl)acetamide With trichlorophosphate In diethyl ether at 20℃; for 2h; Stage #2: N,N-dimethyl(methylene)ammonium chloride In diethyl ether at 20℃; Stage #3: With perchloric acid In isopropyl alcohol at 0℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With acetyl chloride In acetonitrile at 20 - 30℃; | 1 Example 1 : Synthesis of 3-(dimethylamino)-1-(3-(benzyloxy)phenyl)-2- methyl-1-propanone (1); (I)At room temperature 1-(3-(benzyloxy)phenyl)propan-1-one (145.0 g; 0.6 mol) was dissolved in acetonitrile (375 ml) in a 500 ml 3 neck-round bottom flask equipped with an over-head stirrer and a thermometer and under stirring N- Methyl-N-methylene-methaneaminium chloride (57.0 g; 0.61 mol) and acetyl chloride (5 ml) were added. After the addition the temperature rose by 100C. The reaction mixture was stirred at room temperature over night, diethyl ether (375 ml) was added and the product was crystallized by cooling to 5-100C within 3 hours. The resulting solid was filtered by suction and dried at 45°C and 100 mbar. The product was obtained as a colorless solid in 50 % yield (94 g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96% | With potassium carbonate In dichloromethane for 6h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In dichloromethane; at 20℃; | To a solution of <strong>[259860-08-7]6-bromo-5-fluoro-1H-indole</strong> (0.86 g, 4.02 mmol) in CH2Cl2 (30 ml) was added N,N-dimethyl methyleneiminium chloride (0.5 g, 5.34 mmol). The mixture was stirred at room temperature overnight and a aqueous sodium hydroxide (0.22 g, 5.50 mmol, 100 ml water) was added. The aqueous solution was extracted into ethyl acetate. The organic extract was dried (anhydrous sodium sulfate) and concentrated under reduced pressure to give (6-Bromo-5-fluoro-1H-indol-3-ylmethyl)-dimethyl-amine as a light green solid (1.06 g). 1H NMR (DMSO) d: 2.12 (s, 6H), 3.48 (s, 2H), 7.34 (s, 1H), 7.50(d, 1H, J=9.9 Hz), 7.62 (d, 1H, J=6.0 Hz). M-H: 269. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | In acetonitrile; at 85℃; for 4.0h; | To a solution of 6-acetamidotetralone (3.9 g, 19.2 mmol) in dry acetonitrile (80 ml) was quickly added, under an argon atmosphere, N-N-dimethylmethyleneiminium chloride (2.15 g, 23 mmol). The reaction mixture was stirred at 85C for 4 hours. After cooling, the precipitate was filtered off, washed with dry acetonitrile and dried in vacuo to give the title compound Ex 1 as a pale-yellow powder (5.41 g, 18.2 mmol, 95%).'H NMR (300 MHz, D20) : 8 2.10 (s, 3H), 2.90 (s, 6H), 7.29 (d, 1H), 7.39 (s, 1H), 7.83 (d, 1H) ; Melting point: 141-143C (uncorrected). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; sodium borohydrid; potassium carbonate;palladium-carbon; In tetrahydrofuran; methanol; acetonitrile; | REFERENCE EXAMPLE 31 6-Acetylamino-2-(N,N-dimethylamino)methyltetralin A THF solution (40 ml) of 6-acetylamino-1-tetralone (1.692 g) was added to an acetonitrile solution (40 ml) of N,N-dimethylmethylene ammonium chloride (2.04 g), then stirred at room temperature for 24 hours, and concentrated. An aqueous solution of 10% potassium carbonate was added to the residue, which was then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, then dried, and concentrated. The residue was dissolved in methanol (50 ml), to which was added sodium borohydride (0.86 g). The reaction mixture was stirred at room temperature for 1 hour, and water was added thereto, which was then extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, then dried, and concentrated. The residue was dissolved in methanol (50 ml), to which were added 10% palladium-carbon (0.4 g) and 1 N hydrochloric acid (20 ml). Then, this was catalytically reduced under a hydrogen pressure of 1 atmosphere, for 12 hours. The palladium-carbon was removed from the reaction mixture through filtration, the filtrate was concentrated, and an aqueous solution of 10% potassium carbonate was added thereto to form a free form compound. Then, this was extracted with ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, then dried, and concentrated. The resulting crude crystals were recrystallized from ethyl acetate-hexane to obtain the entitled compound (1.862 g). m.p.: 104-107 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
REFERENCE EXAMPLE 666-[(Dimethylamino)methyl]-5-methyl-7,8-dihydro-2-naphthalenamine; 1) 6-Acetylamino-1-tetralone (5.5 g, 0.027 mol) and dimethylmethylenammonium chloride (6.3 g, 0.068 mol) were dissolved in a mixed solution of acetonitrile (100 ml) and tetrahydrofuran (100 ml), which was stirred for 48 hours. The crystallized product was collected by filtration, washed with tetrahydrofuran, and dissolved in ethyl acetate. 0.5N Sodium hydroxide solution was added to the solution for liquid separation. The organic layer was concentrated, to give 6-acetylamino-2-[(dimethylamino)methyl]-1-tetralone (4.48 g) as a colorless oily substance.2) 6-Acetylamino-2-[(dimethylamino)methyl]-1-tetralone (260 mg, 1.00 mmol) obtained was dissolved in tetrahydrofuran (10 ml). 1M Methyl magnesium bromide tetrahydrofuran solution (3 ml) (3.00 mmol) was added to the solution under ice-cooling, which was stirred at room temperature for 16 hours. Aqueous ammonium chloride solution was added to the reaction mixture, and extraction was conducted using ethyl acetate. The organic layer was concentrated, and 5N hydrochloric acid and ethyl acetate were added to the residue for liquid separation. Concentrated hydrochloric acid was added to the water layer, which was refluxed for 4 hours. The reaction mixture was concentrated, and 1N sodium hydroxide solution and ethyl acetate were added to the residue and extraction was conducted. The organic layer was concentrated, and the residue was purified by alumina column chromatography (development solvent; ethyl acetate n-hexane=3:7), to give the titled compound (83 mg) as a colorless oily substance.1H-NMR (CDCl3) delta: 2.04 (3H, s), 2.24 (6H, s), 2.28 (2H, t, J=7.4 Hz), 2.66 (2H, t, J=7.4 Hz), 3.04 (2H, s), 3.62 (2H, s), 6.49 (1H, s), 6.51-6.55 (1H, m), 7.10 (1H, d, J=8.1 Hz). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With triethylamine; In dichloromethane; isopropyl alcohol; at 20 - 35℃; for 12h; | Example 1; 10-hydroxy-camptothecin (1.0 kg), dichloromethane (about 13 kg) and isopropanol (about 8 kg) were charged into a suitable reactor. N, N-dimethylmethyleneiminium chloride (0.3-0.5 kg) was added into the reactor. Triethylamine (0.04-0.2 kg) was then added into the resulting mixture at 20-350C and stirred at 20-350C for at least 12 hours. When the reaction was complete, a mixture of hydrochloric acid (32%, 0.06-0.3 kg) and isopropanol (about 5 kg) was added into the resulting mixture . After the addition was completed, the resulting mixture was stirred, filtered, and then washed with dichloromethane (about 3 kg) . The wet solids were dried to give about 1.5 kg of crude topotecan HCl . |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In N,N-dimethyl-formamide; at 20℃; for 1.0h;Inert atmosphere; | Example 29; 1-(4-bromo-2-methyl-1H-indol-3-yl)-N,N-dimethylmethanamineThe compound (140 g) prepared in Example 28 and N,N-dimethylmethylene ammonium chloride (68 g) were added under a nitrogen atmosphere to N,N-dimethylformamide (1.4 L), followed by stirring at room temperature for 1 hour. The reaction mixture was added to a 5N ice-cooled aqueous sodium hydroxide solution (800 mL), and water (2.0 L) was added thereto, followed by extraction with ethyl acetate twice (2.0 L). The organic layer was washed with water (1.0 L) twice and brine (1.0 L) and dried over magnesium sulfate, followed by concentration under reduced pressure. The resulting residue was washed with hexane (500 mL) and then dried to obtain the title compound (140 g) having the following physical properties.TLC:Rf 0.23 (butanol:acetic acid:water=3:1:1)1H-NMR (CDCl3): delta 2.30, 2.31, 3.71, 6.87, 7.10-7.26, 7.20 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In butan-1-ol; at 135℃; for 1h; | Example 43; 1-(4-bromo-2-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamineN,N-dimethylmethyleneammonium chloride (410 mg) was added to a solution of the compound (590 mg) prepared in Example 42 in n-butyl alcohol (10 mL), followed by stirring at 135 C. for 1 hour, and cooling to room temperature. To the reaction mixture tert-butyl methyl ether and 1N hydrochloric acid were added, followed by separation of the organic layer. Thereafter, the aqueous layer was extracted with tert-butyl methyl ether. The aqueous layer was neutralized under ice-cooling with a 5N aqueous sodium hydroxide solution, and the aqueous layer was extracted with methylene chloride. The organic layer was dried over magnesium sulfate and concentrated under reduced pressure to obtain the title compound (510 mg) having the following physical properties.TLC:Rf 0.09 (methylene chloride:methanol=9:1)1H-NMR (CDCl3): delta 2.32, 2.51, 3.69, 7.23, 7.96, 10.69 |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
23% | In acetonitrile; for 2h;Reflux; | General procedure: Dimethylmethyleneiminium chloride (1 eq.) was suspended in dry acetonitrile. 1 eq. of the appropriate indanone was added and the reaction mixture was refluxed for 2 hours. After cooling to room temperature, the product crystallized spontaneously as colourless crystals that were filtered off, were washed with diethyl ether, dichloromethane, and ethyl acetate and dried under vacuo. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
62% | In acetonitrile; for 2h;Reflux; | General procedure: Dimethylmethyleneiminium chloride (1 eq.) was suspended in dry acetonitrile. 1 eq. of the appropriate indanone was added and the reaction mixture was refluxed for 2 hours. After cooling to room temperature, the product crystallized spontaneously as colourless crystals that were filtered off, were washed with diethyl ether, dichloromethane, and ethyl acetate and dried under vacuo. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | In acetonitrile for 2h; Reflux; | General Procedure for the preparation of indanone derivatives (18-25). 41 General procedure: Dimethylmethyleneiminium chloride (1 eq.) was suspended in dry acetonitrile. 1 eq. of the appropriate indanone was added and the reaction mixture was refluxed for 2 hours. After cooling to room temperature, the product crystallized spontaneously as colourless crystals that were filtered off, were washed with diethyl ether, dichloromethane, and ethyl acetate and dried under vacuo. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | In acetonitrile; at 20℃; | General procedure: Synthesis Procedure C. For the title compounds cannot to be obtained with Procedure A and Procedure B, the iminium salts of the amines (Mannich Reagents) were used [29]. A suspension of substrate (1 mmol) and iminium salts of amine (1 mmol) was stirred in acetonitrile or toluene at room temperature (Scheme 2). Precipitated crude product was recrystallized from appropriate solvents to yield the desired Mannich bases. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With sodium hydroxide In dichloromethane at 20℃; Inert atmosphere; Schlenk technique; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
In acetonitrile at 20 - 80℃; for 3h; Inert atmosphere; | 1 Step 1. N.N-dimethyl-l-(lH-pyrrolo[2.3-blpyridin-3-yl)methanamine. To a solution of 1H- pyrrolo[2,3-b]pyridine (25 g, 211.61 mmol) in MeCN (500 mL) was (0117) added dimethylformiminium chloride (25.74 g, 275.09 mmol) at 20 °C under N2. The mixture was stirred at 80 °C for 3 hours. The reaction mixture was cooled down to 20 °C and concentrated under reduced pressure to give the title compound (35 g, crude) as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | Stage #1: 4-benzyloxy-butan-1-ol With oxalyl dichloride In dichloromethane; dimethyl sulfoxide at -78℃; for 1h; Stage #2: With triethylamine In dichloromethane; dimethyl sulfoxide at 0℃; for 0.5h; Stage #3: N,N-dimethyl(methylene)ammonium chloride With 1,8-diazabicyclo[5.4.0]undec-7-ene In dichloromethane; dimethyl sulfoxide at 20℃; for 22h; | 4-(Benzyloxy)-2-methylenebutanal (46): To a solution of oxalyl chloride (2.76 mL, 32.6mmol, 1.5 equiv) in CH2Cl2 (157 mL) was added dropwise at -78 °C DMSO (4.64 mL, 65.3mmol, 3.0 equiv). After stirring for 20 min at that temperature, a solution of 45 (3.92 g,21.8 mmol, 1.0 equiv) in CH2Cl2 (42 mL + 10 mL of washing) was added dropwise over 20min, and the mixture was stirred at -78 °C for 1 h. Triethylamine (15.2 mL, 109 mmol, 5.0equiv) was added, and the resulting mixture was stirred at 0 °C for 30 min. CH2NMe2Cl(4.07 g, 43.5 mmol, 2.0 equiv) and DBU (3.25 mL, 21.8 mmol, 1.0 equiv) were then added;the mixture was stirred at rt for 22 h, the reaction was quenched with sat. NH4Cl (150 mL),and the resulting mixture was extracted with CH2Cl2 (2 x 300 mL). The combined organicextracts were dried over MgSO4 and concentrated under reduced pressure. The residuewas purified by column chromatography (hexane/EtOAc, 30:1 → 10:1) to provide 46(3.56 g, 86% over 2 steps) as a colorless oil.Rf = 0.33 (hexane/EtOAc, 10:1)1H-NMR (400.1 MHz, CDCl3): δ = 9.54 (s, 1H), 7.39-7.24 (m, 5H), 6.39 (dd, J = 0.8, 2.0 Hz,1H), 6.08 (d, J = 0.5 Hz, 1H), 4.51 (s, 2H), 3.60 (t, J = 6.4 Hz, 2H), 2.58 (dt, J = 0.7, 6.4 Hz,2H).13C-NMR (100.6 MHz, CDCl3): δ = 194.4, 147.0, 138.2, 135.6, 128.4, 127.6, 72.8, 67.9, 28.3.IR (neat, ν/cm-1): 3088w, 3063w, 3031w, 2925w, 2858w, 1686s, 1496w, 1454m, 1361m,1101s, 1029w, 948m, 737s, 698s..HRMS (EI): m/z calcd for C12H14O2 [M]+: 190.0989, found: 190.0991. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | Stage #1: 3-cyclohexyl-1H-indole; N,N-dimethyl(methylene)ammonium chloride In tetrahydrofuran at 20℃; for 24h; Inert atmosphere; Schlenk technique; Stage #2: With triethylamine In tetrahydrofuran for 2h; Inert atmosphere; Schlenk technique; | Synthesis of 4b : Dimethylmethyleneammonium chloride (1.20 g, 12.8 mmol) and 3-cyclohexylindole 4a (1.27 g, 6.4 mmol) were added to tetrahydrofuran (20 mL). The mixture was stirred for 24 h at ambient temperature, gradually forming a yellow suspension. Triethylamine (1.8 mL, 13.0 mmol) was added to the mixture, and stirring was continued for 2 h. The solvent was removed in vacuo, affording a white residue. The residue was suspended in water (60.0 mL), and the product was extracted with dichloromethane (2 ×20 mL). The combined organic layers were dried over an- hydrous MgSO 4 , and the solvent was removed in vacuo to afford 4b (1.50 g, 91%) as a pale-yellow oil. 1H NMR (400 MHz, CDCl3) δ= 7.72 (d, J = 7.9 Hz, 1H), 7.48 (d, J = 8.2 Hz, 1H), 7.27 (t, J = 7.5 Hz, 1H), 7.17 (t, J = 7.5 Hz, 1H), 6.97 (s, 1H), 4.73 (s, 2H), 2.94 -2.91 (m, 1H), 2.36 (s, 6H), 2.20 (d, J = 6.6 Hz, 2H), 1.94 -1.85 (m, 3H), 1.60 -1.50 (m, 4H), 1.39 (m, 1H); 13CNMR (100 MHz, CDCl3) δ= 160.27, 150.29, 146.87, 145.15, 144.45, 142.23, 141.61, 132.77, 91.45, 90.86, 65.66, 58.23, 57.01, 49.85, 49.47, 48.52; HRMS (EI): m/z [M] + calcd for C17H24N2 + : 256.1939, found: 256.1940. |
Tags: 30354-18-8 synthesis path| 30354-18-8 SDS| 30354-18-8 COA| 30354-18-8 purity| 30354-18-8 application| 30354-18-8 NMR| 30354-18-8 COA| 30354-18-8 structure
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P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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