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Chemical Structure| 3048-48-4 Chemical Structure| 3048-48-4

Structure of 3048-48-4

Chemical Structure| 3048-48-4

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Product Details of [ 3048-48-4 ]

CAS No. :3048-48-4
Formula : C8H7NS
M.W : 149.21
SMILES Code : CC1=C2N=CSC2=CC=C1
MDL No. :MFCD11975739
InChI Key :PIUXNZAIHQAHBY-UHFFFAOYSA-N
Pubchem ID :18272

Safety of [ 3048-48-4 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301+H311-H319-H332-H412
Precautionary Statements:P280-P301+P310+P330-P305+P351+P338-P312
Class:6.1
UN#:2810
Packing Group:

Application In Synthesis of [ 3048-48-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3048-48-4 ]

[ 3048-48-4 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3048-48-4 ]
  • [ 2268-77-1 ]
YieldReaction ConditionsOperation in experiment
83% With 1.3-propanedithiol; dimethyl sulfoxide; potassium hydroxide; at 130℃; for 12h;Inert atmosphere; General procedure: To a solution of benzothiazoles or benzoxazoles (1, 1 mmol) in DMSO (3 mL), was added KOH (280 mg, 5 equiv) and 1,3-propanedithiol (207 μL, 2 mmol). The reaction mixture was heated under argon at 130 C for 12 h. After cooling to room temperature, water (10 mL) was added. The pH of the reaction mixture was adjusted to 3-4 using 5% HCl. The resulting mixture was extracted with ethyl acetate (15 mL ×2). The organic layer was washed with water and brine, dried over anhydrous MgSO4 and concentrated using rotary evaporator. The crude product was purified by silica gel column chromatography using ethyl acetate/n-hexane as eluent to afford the corresponding heteroaryl thiols 3.
 

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