Alternatived Products of [ 30877-30-6 ]
Product Details of [ 30877-30-6 ]
| CAS No. : | 30877-30-6 |
MDL No. : | MFCD11521319 |
| Formula : |
C10H11N
|
Boiling Point : |
- |
| Linear Structure Formula : | - |
InChI Key : | - |
| M.W : |
145.20
|
Pubchem ID : | - |
| Synonyms : |
|
Safety of [ 30877-30-6 ]
| Signal Word: | Warning |
Class: | N/A |
| Precautionary Statements: | P305+P351+P338 |
UN#: | N/A |
| Hazard Statements: | H319 |
Packing Group: | N/A |
| GHS Pictogram: |
|
Application In Synthesis of [ 30877-30-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 30877-30-6 ]
- 1
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[ 791609-49-9 ]
-
[ 30877-30-6 ]
| Yield | Reaction Conditions | Operation in experiment |
| 91% |
With manganese(IV) oxide; 4 A molecular sieve In benzene at 40 - 50℃; for 2h; |
|
- 2
-
[ 30877-30-6 ]
-
[ 791609-49-9 ]
| Yield | Reaction Conditions | Operation in experiment |
| 95% |
With sodium cyanoborohydride In acetic acid at 12℃; for 2h; |
|
| 90% |
With sodium cyanoborohydride; acetic acid at 12℃; for 2h; |
|
Reference：
[1]Chandra, Tilak; Brown, Kenneth L.
[Tetrahedron Letters, 2005, vol. 46, # 12, p. 2071 - 2074]
[2]Brown, Kenneth L.; Chandra, Tilak; Zou, Shawn; Valente, Edward J.
[Nucleosides, nucleotides and nucleic acids, 2005, vol. 24, # 8, p. 1147 - 1165]
- 3
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[ 610-91-3 ]
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[ 1188-33-6 ]
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[ 30877-30-6 ]
| Yield | Reaction Conditions | Operation in experiment |
|
With nitrogen; In N,N-dimethyl-formamide; |
EXAMPLE 27 Preparation of 5,6-dimethylindole A 500-ml. three-necked flask fitted with a thermometer and 15-cm. Vigreux column connected to a descending condenser with a receiver and nitrogen inlet was charged with 33.0 g. of <strong>[610-91-3]5-nitropseudocumene</strong>, 48.3 g. of N,N-dimethylformamide diethyl acetal, and 200 ml. of N,N-dimethylformamide. The reaction vessel was immersed in an oil bath, preheated to 165, for 31 hours. The pot temperature was maintained above 140 by continuous distillation of the formed ethanol. The volatile components were removed by vacuum distillation at 25/0.5 mm. The residue was triturated with methanol and the insoluble material crystallized from 600 ml. methanol to give 25.5 g. (58%) of trans-β-dimethylamino-2,5-dimethyl-4-nitrostyrene as dark red needles having a melting point of 130-131. |
- 4
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[ 30877-30-6 ]
-
[ 611-73-4 ]
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[ 1538596-12-1 ]
| Yield | Reaction Conditions | Operation in experiment |
| 88% |
With iodine; oxygen; palladium diacetate; caesium carbonate In 1-methyl-pyrrolidin-2-one at 45℃; for 12h; Schlenk technique; Sealed tube; |
Representative procedure for the synthesis of 3-acylindoles (3)
General procedure: A 10 mL oven-dried Schlenk tube was charged with phenylglyoxylic acid 1a (49.5mg, 0.33mmol), indole 2a (35.1mg, 0.3mmol), I2 (164.5mg, 0.65mmol), Pd(OAc)2 (10mol%, 6.7mg, 0.03mmol), Cs2CO3 (292mg, 0.9mmol). The tube was evacuated and filled with O2 (this procedure was repeated three times). Then NMP (1.5mL) were added with a syringe under a counter flow of O2. The tube was sealed with a screw cap. The reaction was stirred at 45°C for 12h, and was then allowed to cool to ambient temperature. The mixture was added 20mL EtOAc, and filtered, washed with water. The organic layers were dried over Na2SO4 and filtered. Solvents were evaporated under reduced pressure. The residue was purified by flash column chromatography with hexane/ethyl acetate to give the corresponding product 3. |
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