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Chemical Structure| 314298-14-1 Chemical Structure| 314298-14-1

Structure of 314298-14-1

Chemical Structure| 314298-14-1

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Product Details of [ 314298-14-1 ]

CAS No. :314298-14-1
Formula : C8H10FNO
M.W : 155.17
SMILES Code : NC1=CC(C)=C(F)C=C1OC
MDL No. :MFCD15527525

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Application In Synthesis of [ 314298-14-1 ]

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  • Downstream synthetic route of [ 314298-14-1 ]

[ 314298-14-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 314298-13-0 ]
  • [ 314298-14-1 ]
YieldReaction ConditionsOperation in experiment
99% Pd-C; In ethanol; Step 2: 4-Fluoro-2-methoxy-5-methyl-phenylamine: A solution of <strong>[314298-13-0]1-fluoro-5-methoxy-2-methyl-4-nitro-benzene</strong> (5.5 g, 29.3 mmol) and 10% Pd-C (1.56 g) in ethanol (300 mL, 0.1 M) was hydrogenated at 1 atm. After stirring overnight, the solution was flushed through a pad of silica gel using 400 mL of ethanol as the eluant. The filtrate was concentrated under reduced pressure to afford 4-fluoro-2-methoxy-5-methyl-phenylamine (4.5 g, 99%) as a pale purple solid: mp 108-110 C.; Rf 0.35 (30% ethyl acetate in heptane); 1H NMR (DMSO-d6, 300 MHz) delta 6.62 (d, J=11.4 Hz, 1H)', 6.43 (d, J=7.8 Hz, 1H), 3.70 (s, 3H), 2.02 (d, J=1.8 Hz, 3H); ESI-LC/MS m/z calcd for C8H10FNO: 155.1; Found 156.0 (M+1)+. Anal. calcd for C8H10FNO: C, 61.92; H, 6.50. Found: C, 61.64; H, 6.53.
 

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