Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 3176-62-3 | MDL No. : | MFCD00601361 |
Formula : | C8H8N2 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | FWOPJXVQGMZKEP-UHFFFAOYSA-N |
M.W : | 132.16 | Pubchem ID : | 820804 |
Synonyms : |
|
Num. heavy atoms : | 10 |
Num. arom. heavy atoms : | 9 |
Fraction Csp3 : | 0.12 |
Num. rotatable bonds : | 0 |
Num. H-bond acceptors : | 1.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 41.06 |
TPSA : | 28.68 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.72 cm/s |
Log Po/w (iLOGP) : | 1.18 |
Log Po/w (XLOGP3) : | 1.95 |
Log Po/w (WLOGP) : | 1.87 |
Log Po/w (MLOGP) : | 1.45 |
Log Po/w (SILICOS-IT) : | 2.53 |
Consensus Log Po/w : | 1.8 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -2.55 |
Solubility : | 0.369 mg/ml ; 0.00279 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.18 |
Solubility : | 0.879 mg/ml ; 0.00665 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -3.26 |
Solubility : | 0.0721 mg/ml ; 0.000546 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 1.21 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P280-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H317-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With dmap; triethylamine; In acetonitrile; at 0 - 20℃; for 3h; | 1-(tert-butyl)-<strong>[3176-62-3]3-methyl-1H-indazole</strong>-1-carboxylate (32-3); A stirred solution of 610 mg (4.61 mmol) of 32-2 in 5 mL of acetonitrile under nitrogen was treated with 113 mg (0.92 mmol) of DMAP and 704 uL (5.08 mmol) of triethylamine. This mixture was cooled to 0 C. in an icebath. A solution of 1.21 g (5.54 mmol) of (BOC)2O in 10 mL acetonitrile was then added dropwise using an addition funnel. Upon completion of addition, the icebath was removed and the mixture was stirred for an additional 3 hours at room temperature. Solvent was removed in vacuo, and the residue was partitioned between ether and H2O. The pH was adjusted to 2 with 1 N HCl, and the organic layer was separated, dried (MgSO4), filtered and concentrated in vacuo to an orange oil. This crude material was purified by flash chromatography over silica gel with 1:4 ethyl acetate/hexanes to give 956 mg of the desired product 32-3 as a solid. MS: M+1=233.3. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrogenchloride; sodium sulfite; sodium nitrite; In water; | a) 3-Methyl-1H-indazole Concentrated HCl (23 mL) was added to neat 2-aminoacetophenone (11.3 g., 84 mmol) at -10 C. The resulting thick suspension was stirred rapidly while warming to -5 C. Sodium nitrite (5.8 g., 84 mmol) was added dropwise over 15 minutes as a solution in 13 mL of water while maintaining the temperature between -5 C. and 3 C. The reaction mixture was stirred an additional 15 minutes at 0 C., during which time it became an orange solution. At this time, the reaction was poured into a solution of sodium sulfite and sodium bisulfate at 5 C. [solution was made by dissolving sodium sulfite (21.12 g., 160 mmol) in a minimal amount of water (about 75 mL) and adding sodium bisulfate until no more dissolved. A small amount of water was added to dissolve any remaining solids]. The resulting yellow solution was allowed to stir for 15 minutes after which time a solid precipitated. The suspension was allowed to stand at room temperature overnight during which time the precipitate was replaced by a red oil floating on top of the aqueous layer. The entire mixture was basified with 1N sodium hydroxide and extracted with ethyl ether. The organic layer was washed with brine, dried (MgSO4), decolorized, and concentrated to a light yellow solid which was recrystallized from ethyl ether/pentane to afford 3.83 g. of the title A product as a tan crystalline solid, m.p. 110-113 C. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
66% | With dmap; acetic anhydride; triethylamine; In dichloromethane; | Step A 1-Acetyl-<strong>[3176-62-3]3-methyl-1H-indazole</strong> <strong>[3176-62-3]<strong>[3176-62-3]3-Methyl-1H-indazol</strong>e</strong> (6.157 g, 44.6 mmol) in CH2 Cl2 (100 mL) was treated with acetic anhydride (22.75 g, 223 mmol), triethylamine (22.5 g, 228 mmol) and DMAP (0.54 g, 4.5 mmol). The mixture was stirred 1 h at 20 C., poured into water (100 mL) and extracted with CH2 Cl2 (2*100 mL). The extracts were dried (Na2 SO4), concentrated and the residue recrystallized from hexane to give the title compound (4.12 g, 66%) as a white crystalline solid; mp 70-71 C. (from hexane); 1 H NMR (360 MHz, CDCl3) delta 8.41 (d, J=8.4 Hz, 1H, indazole), 7.64 (d, J=8.4 Hz, 1H, indazole), 7.54 (t, J=8.4 Hz, 1H, indazole), 7.35 (t, J=8.4 Hz, 1H, indazole), 2.75 (s, 3H, Ac), 2.58 (s, 3H, Me); MS (CI+) m/e 175 (M+H+); Anal. calcd for C10 H10 N2 O: C, 68.95; H, 5.97; N, 16.08. Found: C, 68.80; H, 5.58; N, 16.18. |
66% | With dmap; acetic anhydride; triethylamine; In dichloromethane; | Step A 1-Acetyl-<strong>[3176-62-3]3-methyl-1H-indazole</strong> <strong>[3176-62-3]<strong>[3176-62-3]3-Methyl-1H-indazol</strong>e</strong> (6.157 g, 44.6 mmol) in CH2 Cl2 (100 mL) was treated with acetic anhydride (22.75 g, 223 mmol), triethylamine (22.5 g, 223 mmol) and DMAP (0.54 g, 4.5 mmol). The mixture was stirred 1 h at 20 C., poured into water (100 mL) and extracted with CH2 Cl2 (2*100 mL). The extracts were dried (Na2 SO4), concentrated and the residue recrystallized from hexane to give the title compound (4.12 g, 66%) as a white crystalline solid; mp 70-71 C. (from hexane); 1 H NMR (360 MHz, CDCl3) delta8.41 (d, J=8.4 Hz, 1H, indazole), 7.64 (d, J=8.4 Hz, 1H, indazole), 7.54 (t, J=8.4 Hz, 1H, indazole), 7.35 (t, J=8.4 Hz, 1H, indazole), 2.75 (s, 3H, Ac), 2.58 (s, 3H, Me); MS (CI+) m/e 175 (M+H+); Anal. calcd for C10 H10 N2 0: C, 68.95, H, 5.97: N, 16.08. Found: C, 68.80;H, 5.58: N, 16.18. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With hydrazine; In ethylene glycol; | A. 3-Methylindazole To a stirring solution of 36.2 g (0.26 mol) of 2-Fluoroacetophenone in 120 mL of ethylene glycol is added 8.6 mL (0.27 mol, 1.05 equiv.) of hydrazine. The resulting solution is stirred 2 h at RT and then heated at 165 C. for 40 h. The solution is cooled to RT, poured into CH2 Cl2 (200 mL) and extracted with H2 O (2*200 mL). The organic layers were combined, dried (MgSO4), and the solvent removed in vacuo. Purification of the crude material by recrystallization form hexane/CHCl3 afforded 26 g of 3-Methylindazole as a light tan solid: 1 H NMR (CDCl3, 300 MHz) delta7.73 (d, 1H, J=8.1), 7.44 (m, 2H), 7.19 (dd, 1H, J=7.0,7.0), 2.67 (s, 3H). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 23℃; | 1 mmol of an oxime reaction product (formed from heating 1-(2-aminophenyl)ethanone, hydroxylamine (supplied as hydroxylamine hydrochloride), and sodium hydroxide at 60) was dissolved in dichloromethane (15 mL), and 2 mmol of triethylamine was added. The reaction was stirred at 23 for 15 minutes, then cooled to 0 C. A 5 mL solution of methanesulfonylchloride (1.2 mmol) in dichloromethane was added slowly, and the reaction was warmed to 23 C. over 5 hours. The reaction was concentrated in vacuo and purified via column chromatography. The product was isolated as a white or off-white to yellow solid or viscous oil, and the yield was about 77%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 15h;Inert atmosphere; | Preparation 28 Preparation of fe/t-butyl (3-methyl-1 H-indazol-1-yl)acetate.A mixture of 3-methyl-1 H-indazole (5 g, 39 mmol) (available from a number of commercial sources including 3B Scientific Corporation, Libertyville, IL 60048 and J & W PharmLab LLC, Levittown, PA 19057), te/t-butyl bromoacetate (8.86 g, 45 mmol) and potassium carbonate (7.8 g, 56 mmol) in 100 mL of anhydrous DMF was heated at 60 0C under nitrogen for 15 h. The reaction mixture was cooled to room temperature, diluted with water and extracted with ethyl acetate three times. The combined organic layers were washed sequentially with water and brine, and were dried over MgSO4. The mixture was filtered and concentrated under reduced pressure. The residue was purified by flash chromatography (ethyl acetate in heptane 0% to 33%) to isolate the title compound (7.05 g, 75%). MS (ES+) calc: 247.3 (M+1 ). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
10% | With triethylamine; In toluene; at 100℃; for 6h; | General procedure: Isonicotinic acid (0.42 mmol) was dissolved in SOCl2 (0.7 mL) and refluxed for 1 h. After cooling, the excess of SOCl2 was removed in vacuo, and the residue oil was dissolved in cold anhydrous toluene (3 mL). To this solution, a mixture of H-indazole-3-carboxylic acid phenylamide 234 (0.42 mmol) and Et3N (0.46 mmol) in 2.8 mL of anhydrous toluene was added. The mixture was stirred at 100 C for 6 h. After cooling, the precipitate was recovered by vacuum filtration and washed with water, followed by 0.5 N NaOH, resulting in 3n, which was recrystallized with ethanol. Yield = 21%; mp = 180 C dec. (EtOH); 1H NMR (CDCl3) delta 7.20 (t, 1H, Ar, J = 7.6 Hz), 7.40 (t, 2H, Ar, J = 7.60 Hz), 7.60 (t, 1H, Ar, J = 8.0 Hz), 7.70 (d, 2H, Ar, J = 8.0 Hz), 7.75 (t, 1H, Ar, J = 8.4 Hz), 7.95 (d, 2H, Ar, J = 4.8 Hz), 8.55 (exch br s, 1H, NH), 8.60 (d, 2H, Ar, J = 8.4 Hz), 8.95 (d, 2H, Ar, J = 4.8 Hz). Anal. (C20H14N4O2) C, H, N. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
20% | With triethylamine; In dichloromethane; at 0 - 20℃; | General procedure: To a cooled (0 C) suspension of 1H-indazole-3-carboxylic acid phenylamide 234 (0.42 mmol) and a catalytic amount of Et3N (0.05 mL) in anhydrous CH2Cl2 (1-2 mL), the appropriate aroyl chloride (1.25 mmol) was added. The mixture was stirred for 1-2 h at 0 C and then for 1-3 h at room temperature. The precipitate was filtered off, and the solvent was evaporated in vacuo. Cold water (20 mL) was added, the mixture was neutralized with 0.5 N NaOH, and the precipitate was recovered by vacuum filtration. For compounds 3c, 3e-f, 3k, and 3q, the reaction mixture was extracted with CH2Cl2 (3 × 15 mL) after dilution. The solvent was dried over sodium sulphate to obtain the desired final compounds. Compound 3c was purified by column chromatography using toluene/ethyl acetate 8:2 as eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
33% | General procedure: Sodium hydride (0.53 g, 6.6 mmol, 60% oil dispresion) was added to the stirred solution of the corresponding azole (3.3 mmol) in anhydrous THF (2 mL) at room temperature. After 15 min, freshly prepared 2-(chloromethyl)-4,5-dihydro-1H-imidazole 2 (0.47 g, 4.0 mmol) was added and the reaction mixture was stirred at ambient temperature for 6 h. The N-alkylation products 3, 5, 7 and 8 were isolated upon quenching the reaction mixture with water (5 mL) followed by extraction with dichloromethane (3 × 5 mL). The combined organic layers were dried over anhydrous sodium sulfate and evaporated under reduced pressure. The oily residue thus obtained was purified on silica with use of chromatotron (Et3N/MeOH/AcOEt 1:5:100). All products were very polar with Rf values close to 0.05.The N-alkylation reaction of indazoles (1) provided the desired N1 substituted products (3) along with the N2 substituted side product. The latter compounds demonstrated considerably lower Rf than 3 and were not isolated in pure form. The alkylation reactions of benzotriazoles 6a and 6c allowed the isolation of N1 substituted products 7a-b (higher Rf) and N2 isomer 8b (lower Rf). However, in the case of 4-methyl-benzotriazole 6b only the N2 substituted isomer 8a was isolated as a pure product.The products 3, 5, 7 and 8 were then converted into water-soluble hydrochloride salts suitable for biological tests with use of methanolic hydrochloric acid solution or by passing gaseous hydrogen chloride through dichloromethane solution of the corresponding free base. |
Tags: 3176-62-3 synthesis path| 3176-62-3 SDS| 3176-62-3 COA| 3176-62-3 purity| 3176-62-3 application| 3176-62-3 NMR| 3176-62-3 COA| 3176-62-3 structure
[ 5757-85-7 ]
1,3-Dimethyl-1H-indazol-5-amine
Similarity: 0.86
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :