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Chemical Structure| 318517-56-5 Chemical Structure| 318517-56-5

Structure of 318517-56-5

Chemical Structure| 318517-56-5

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Product Details of [ 318517-56-5 ]

CAS No. :318517-56-5
Formula : C10H10FN3
M.W : 191.21
SMILES Code : FC1=CC=CC(N2N=C(C)C=C2C)=N1
MDL No. :MFCD00215378

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Application In Synthesis of [ 318517-56-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 318517-56-5 ]

[ 318517-56-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 318517-56-5 ]
  • [ 5932-27-4 ]
  • ethyl 1-(6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridin-2-yl)-1H-pyrazole-3-carboxylate [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% Step 2: Nitrogen protection, <strong>[5932-27-4]1H-<strong>[5932-27-4]pyrazole-3-carboxylic acid ethyl ester</strong></strong> (3.7 g, 26.2 mmol) dissolved in dry DMF(25 mL), 60percent NaH (1.0 g, 26.2 mmol) was added in four portions at 0 °C. After stirring for 15 min, slowly add 2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-fluoropyridine (4.0 g, 20.9 mmol), warmed to 110 ° C and stirred overnight.The reaction was quenched by adding an appropriate amount of water and extracted three times with dichloromethane.The combined organics were dried with MgSO4 for 2 h. Filter out MgSO4,The solvent was distilled off, and the crude product was separated by column chromatography (eluent petroleum ether (60-90 ° C) / ethyl acetate, 15:1 by volume) to obtain white powder.Final (5.7 g, yield 88percent).
 

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