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Chemical Structure| 320423-50-5 Chemical Structure| 320423-50-5

Structure of 320423-50-5

Chemical Structure| 320423-50-5

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Product Details of [ 320423-50-5 ]

CAS No. :320423-50-5
Formula : C9H13N3OS
M.W : 211.28
SMILES Code : O=CC1=CN=C(N2CCN(C)CC2)S1
MDL No. :MFCD01568852

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Application In Synthesis of [ 320423-50-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 320423-50-5 ]

[ 320423-50-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 1003-61-8 ]
  • [ 55-86-7 ]
  • [ 320423-50-5 ]
YieldReaction ConditionsOperation in experiment
50% With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 90℃; for 6h; In a 25 ml flask are added 0.5 g of <strong>[1003-61-8]2-aminothiazole-5-carboxaldehyde</strong>, 1.35 g of K2CO3 in 5 ml of DMF. After dissolution, 0.901 g of 2-chloro-N-(2-chloroethyl)-N-methylethanamine hydrochloride are added. The mixture is left at room temperature for lh then heated to 90C for 5h. Next, the mixture is evaporated, dissolved in 100 ml of water, and the aqueous phase is extracted three times with ethyl acetate. The organic phases are combined, washed with sodium chloride saturated solution, dried over sodium sulfate, filtered, and evaporated to yield 420 mg (50%) of 2-(4- methylpiperazin-l-yl)thiazole-5-carboxaldehyde.1H-NMR: deltaEta pm 400 MHz, DMSO: 9.70 (1H, s), 8.13 (1H, s), 3.60 (4H, m), 2.43 (4H, m), 2.24 (3H, s).
 

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