32412-39-8|1-(5-Bromothiophen-2-yl)propan-1-one| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 32412-39-8 ] Purity: 97% (stabilized with Cu+HQ+MgO) SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 32412-39-8 ]

CAS No. :	32412-39-8
Formula :	C₇H₇BrOS
M.W :	219.10
SMILES Code :	CCC(C1=CC=C(Br)S1)=O
MDL No. :	MFCD01993682
InChI Key :	JQAYKLHWCBPAEX-UHFFFAOYSA-N
Pubchem ID :	255121

Safety of [ 32412-39-8 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H319
Precautionary Statements:	P305+P351+P338

Application In Synthesis of [ 32412-39-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 32412-39-8 ]

[ 32412-39-8 ] Synthesis Path-Downstream 1~33

1
[ 1003-09-4 ]
[ 79-03-8 ]
[ 32412-39-8 ]

Yield	Reaction Conditions	Operation in experiment
95%		To a stirred solution of AlCl3 (29.44 g, 221 mmol) in EDC (300 mL) at 0C, propionyl chloride (17.02 g, 184 mmol) was added and reaction mixture was stirred for 20 min at 0C. To this solution, compound 231 (30 g, 184 mmol) was added and further stirred at room temperature for overnight. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was diluted with water and extracted with DCM. The combined organic layers were dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure to afford the title compound 227 (38.20 g, 95%) as brown coloured solid; TLC: 20% EtOAc/ hexane (Rf: 0.4); 1H NMR (400 MHz, DMSO-d6): δ 7.79 (d, J=4.4 Hz, 1H), 7.38 (d, J=4.0 Hz, 1H), 2.97-2.92 (m, 2H), 1.07 (t, J=7.2 Hz, 3H); LCMS Calculated for C7H7BrOS: 217.94; Observed: 220.80 (M + 2)+.

References: [1]Patent: WO2018/160878,2018,A1 .Location in patent: Page/Page column 387.
[2]Advanced Synthesis and Catalysis,2018,vol. 360,p. 3471 - 3476.
[3]Journal of Chemical Research - Part S,2003,p. 694 - 695.
[4]Recueil des Travaux Chimiques des Pays-Bas,1949,vol. 68,p. 5,29.
[5]Recueil des Travaux Chimiques des Pays-Bas,1949,vol. 68,p. 5,29.
[6]Organic and Biomolecular Chemistry,2015,vol. 13,p. 11651 - 11656.

2
[ 1003-09-4 ]
[ 123-62-6 ]
[ 32412-39-8 ]

References: [1]Journal of the American Chemical Society,1950,vol. 72,p. 3695,3696, 3697.
[2]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 2546 - 2550.

3
[ 32412-39-8 ]
[ 51433-48-8 ]
1-(5-bromo-[2]thienyl)-propan-1-one semicarbazone [ No CAS ]

References: [1]Journal of the American Chemical Society,1950,vol. 72,p. 3695,3696, 3697.

4
[ 32412-39-8 ]
[ 151-50-8 ]
[ 90326-41-3 ]

References: [1]Bulletin de la Societe Chimique de France,1961,p. 2161 - 2165.

7
[ 32412-39-8 ]
[ 90841-28-4 ]

References: [1]Bulletin de la Societe Chimique de France,1961,p. 2161 - 2165.

8
[ 32412-39-8 ]
[ 91335-24-9 ]

References: [1]Bulletin de la Societe Chimique de France,1961,p. 2161 - 2165.

9
[ 32412-39-8 ]
[ 544-97-8 ]
2-bromo-5-<i>tert</i>-pentyl-thiophene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With titanium tetrachloride; In dichloromethane; toluene; at -50 - 20℃;Cooling with acetonitrile ice bath;	To a nitrogen flushed round bottom flask equipped with a stir bar and addition funnel was added 80 mL methylene chloride. TiC14 (2.3 mL, 21.0 mmol) was added and the mixture cooled with a dry ice-acetonitrile bath to about-50C. To this was added Me2Zn (2M in toluene, 10.5 mL, 21 mmol). The resulting thick slurry was allowed to stir for at least 10 minutes. A solution of 1- (5-bromo-thiophen-2-yl)-propan-1-one [prepared as described in JACS 1950, 3695] (2.191 g, 10.1 mmol) in 20 mL methylene chloride was added to the reaction mixture via addition over a period of 35 minutes. The ice bath was allowed to melt and the reaction was allowed to warm up overnight. The reaction was then carefully poured into 500 mL ice/water and then extracted three times with 100 mL methylene chloride. The combined organics were washed twice with 1 N HCI (100 mL) and once with brine (100 mL). The organics were then dried over Na2SO4, treated with charcoal, filtered and concentrated to a residue that was chromatographed over silica gel eluting with 100% hexanes. Evaporation of the proper fractions yielded the product as a colorless liquid (1.256 g, 5.39 mmol). 1H NMR (CDCI3) : δ 6.85 (d, 1 H), 6.53 (d, 1 H), 1.62 (q, 2H), 1.31 (s, 6H), 0.81 (t, 3H).

References: [1]Patent: WO2004/69792,2004,A2 .Location in patent: Page 105-106.

10
[ 32412-39-8 ]
[ 5446-18-4 ]
[ 95-92-1 ]
[ 1013649-25-6 ]