Purity | Size | Price | VIP Price | USA Stock *0-1 Day | Global Stock *5-7 Days | Quantity | |||||
{[ item.p_purity ]} | {[ item.pr_size ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} |
{[ getRatePrice(item.pr_usd, 1,1) ]} | {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]} | {[ item.pr_usastock ]} | Inquiry - | {[ item.pr_chinastock ]} | Inquiry - |
* Storage: {[proInfo.prStorage]}
CAS No. : | 32664-13-4 | MDL No. : | MFCD04108263 |
Formula : | C11H12BrNO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XLCYXINIUJNTPF-UHFFFAOYSA-N |
M.W : | 254.12 | Pubchem ID : | 289296 |
Synonyms : |
|
Num. heavy atoms : | 14 |
Num. arom. heavy atoms : | 6 |
Fraction Csp3 : | 0.36 |
Num. rotatable bonds : | 1 |
Num. H-bond acceptors : | 2.0 |
Num. H-bond donors : | 0.0 |
Molar Refractivity : | 64.36 |
TPSA : | 21.59 Ų |
GI absorption : | High |
BBB permeant : | Yes |
P-gp substrate : | No |
CYP1A2 inhibitor : | Yes |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -5.9 cm/s |
Log Po/w (iLOGP) : | 2.74 |
Log Po/w (XLOGP3) : | 2.74 |
Log Po/w (WLOGP) : | 2.62 |
Log Po/w (MLOGP) : | 3.14 |
Log Po/w (SILICOS-IT) : | 4.1 |
Consensus Log Po/w : | 3.07 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 0.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -3.39 |
Solubility : | 0.103 mg/ml ; 0.000405 mol/l |
Class : | Soluble |
Log S (Ali) : | -2.85 |
Solubility : | 0.361 mg/ml ; 0.00142 mol/l |
Class : | Soluble |
Log S (SILICOS-IT) : | -4.62 |
Solubility : | 0.00608 mg/ml ; 0.0000239 mol/l |
Class : | Moderately soluble |
PAINS : | 0.0 alert |
Brenk : | 0.0 alert |
Leadlikeness : | 0.0 |
Synthetic accessibility : | 2.92 |
Signal Word: | Warning | Class: | |
Precautionary Statements: | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 | UN#: | |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | |
GHS Pictogram: |
![]() |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
79% | Stage #1: 2-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamide With thionyl chloride Stage #2: In diethyl ether at 20℃; for 6h; Stage #3: With sodium hydroxide In water | |
With thionyl chloride In toluene | ||
With thionyl chloride Ambient temperature; |
Multi-step reaction with 2 steps 1: thionyl chloride / toluene 2: NaOH / methanol / Heating | ||
With thionyl chloride In dichloromethane | ||
3.63 g | With thionyl chloride at 20℃; for 24h; Cooling with ice; | |
Multi-step reaction with 2 steps 1.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 1.2: 3 h / 20 °C / Inert atmosphere 2.1: sodium hydroxide / ethanol / 0.5 h / 25 °C / Inert atmosphere | ||
Multi-step reaction with 2 steps 1: thionyl chloride / toluene / 3 h / Inert atmosphere; Reflux 2: sodium hydroxide / methanol / 1 h / Reflux | ||
Multi-step reaction with 2 steps 1: thionyl chloride / toluene / 3 h / 0 °C / Reflux; Inert atmosphere 2: sodium hydroxide / diethyl ether; methanol / 1 h / Reflux |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | With triethylamine; triphenylphosphine at 100℃; for 36h; Yield given; | |
81% | With triethylamine; triphenylphosphine at 100℃; for 36h; Yields of byproduct given; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 0.333333h; Stage #2: 2-methylphenyl aldehyde In tetrahydrofuran; hexane at -78 - 20℃; for 3.5h; Further stages.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 30% 2: 10% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With Ph2CuLi*LiCN In diethyl ether at 0℃; for 0.5h; Stage #2: benzyl bromide In diethyl ether at 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1: 35% 2: 10% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With Ph2CuLi*LiCN In diethyl ether at 0℃; for 0.5h; Stage #2: benzyl chloride In diethyl ether at 20℃; for 1h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With Ph2CuLi*LiCN In diethyl ether at 0℃; for 0.5h; Stage #2: With water; ammonium chloride In diethyl ether |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium hydroxide In methanol Heating; | ||
1.857 g | With sodium hydroxide In methanol for 1h; Reflux; | |
1.857 g | With sodium hydroxide In methanol; diethyl ether for 1h; Reflux; | To the same round-bottom flask was added NaOH (15 mmol, 1.5 equiv) and MeOH (80 mL), and the mixture was heated to reflux open to air for 1 hour. After cooling to room temperature, diethyl ether (200 mL) was added. The resulting solution was washed 3 times with brine. The organic layer was dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure. The crude mixture was purified via flash column chromatography (0%=>10% acetone in hexanes) to afford the desired phenyloxazoline. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52.1% | In tetrahydrofuran at 20 - 50℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With potassium phosphate; copper(l) iodide; <i>L</i>-proline In dimethyl sulfoxide at 110℃; for 24h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate In toluene for 48h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate In toluene for 72h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: CH2Cl2 2: thionyl chloride / toluene 3: NaOH / methanol / Heating | ||
Multi-step reaction with 2 steps 1: dichloromethane / 4 h / 20 °C / Cooling with ice 2: thionyl chloride / 24 h / 20 °C / Cooling with ice | ||
Multi-step reaction with 3 steps 1.1: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 2.2: 3 h / 20 °C / Inert atmosphere 3.1: sodium hydroxide / ethanol / 0.5 h / 25 °C / Inert atmosphere |
Multi-step reaction with 3 steps 1: triethylamine / 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere 2: thionyl chloride / toluene / 3 h / Inert atmosphere; Reflux 3: sodium hydroxide / methanol / 1 h / Reflux | ||
Multi-step reaction with 3 steps 1: triethylamine / 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere 2: thionyl chloride / toluene / 3 h / 0 °C / Reflux; Inert atmosphere 3: sodium hydroxide / diethyl ether; methanol / 1 h / Reflux | ||
Multi-step reaction with 2 steps 1.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 2.1: thionyl chloride 2.2: 6 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: 92 percent / thionyl chloride / 24 h / 40 °C 2: CH2Cl2 3: thionyl chloride / toluene 4: NaOH / methanol / Heating | ||
Multi-step reaction with 3 steps 1: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 2 h / Reflux 2: dichloromethane / 4 h / 20 °C / Cooling with ice 3: thionyl chloride / 24 h / 20 °C / Cooling with ice | ||
Multi-step reaction with 4 steps 1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 20 °C / Inert atmosphere 2.1: triethylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere 3.1: triethylamine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere 3.2: 3 h / 20 °C / Inert atmosphere 4.1: sodium hydroxide / ethanol / 0.5 h / 25 °C / Inert atmosphere |
Multi-step reaction with 4 steps 1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 0 - 20 °C / Inert atmosphere 2: triethylamine / 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere 3: thionyl chloride / toluene / 3 h / Inert atmosphere; Reflux 4: sodium hydroxide / methanol / 1 h / Reflux | ||
Multi-step reaction with 4 steps 1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 0 - 20 °C / Inert atmosphere 2: triethylamine / 1,4-dioxane / 1 h / 0 - 20 °C / Inert atmosphere 3: thionyl chloride / toluene / 3 h / 0 °C / Reflux; Inert atmosphere 4: sodium hydroxide / diethyl ether; methanol / 1 h / Reflux | ||
Multi-step reaction with 3 steps 1.1: thionyl chloride / 6 h / Reflux; Inert atmosphere 2.1: dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere 3.1: thionyl chloride 3.2: 6 h / 20 °C |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 4 steps 1: 1.) BuLi, B(OMe)3, 2.) Na2CO3, H2O / 2.) (PPh3)4Pd / 1.) THF, hexane, -78 deg C, 30 min; 0 deg C, 1.5 h, 2.) DME, EtOH, reflux, 16 h 2: 70 percent / HCl, H2O / 16 h / Heating 3: 94 percent / TFAA / CHCl3 / 0.5 h / Ambient temperature 4: 90 percent / HBr, H2O / acetic acid / 16 h / Heating |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: 1.) BuLi, B(OMe)3, 2.) Na2CO3, H2O / 2.) (PPh3)4Pd / 1.) THF, hexane, -78 deg C, 30 min; 0 deg C, 1.5 h, 2.) DME, EtOH, reflux, 16 h 2: 70 percent / HCl, H2O / 16 h / Heating 3: 94 percent / TFAA / CHCl3 / 0.5 h / Ambient temperature |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: 81 percent / Et3N, PPh3 / PdCl2(PPh3)2, NiCl2(DPPE) / 36 h / 100 °C / 2280 Torr 2: 97 percent / aq. acid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: (i) Mg, J2, THF, (ii) /BRN= 106924/ 2: aq. HCl / 5 h / Heating 3: B2H6 / tetrahydrofuran |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: (i) Mg, J2, THF, (ii) /BRN= 128556/ 2: aq. HCl / Heating 3: B2H6 / tetrahydrofuran |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
15.a 1'-Methyl-1,2',3,3',4',5',6',7'-octohydrospiro[isobenzofuran-1,4'-azepine]-3-one a. Reaction of 2,3,4,5,6,7-hexahydro-1-methylazepin-4-one and 2-(2-bromophenyl)-4,4-dimethyl-2-oxazoline by the method described in Example 1c provides 4-[2-(4,4-dimethyl-2-oxazolin-2-yl)phenyl]-2,3,4,5,6,7-hexahydro-4-hydroxy-1-methylazepine. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
a. Reaction of 1-benzyl-3-pyrrolidone and 2-(2-bromophenyl)-4,4-dimethyl-2-oxazoline by the method described in Example 1c provides 1-benzyl-3-[2-(4,4-dimethyl-2-oxazolin-2-yl)phenyl]-3-hydroxypyrrolidine as an oil. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
92% | In benzene keeping under Ar (60°C), keeping (15 min, 60°C), cooling; filtration, washing (hexane), recrystn. (CHCl3/hexane); |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With n-butyllithium; water; ammonium chloride In diethyl ether; hexane; ethyl acetate under N2, n-BuLi in hexane added to a soln. of the organic compound (-78°C), stirred (30 min), siphoned to B(OCH3)3 or BH3*THF, precooled (-78°C), stirred (ice bath, 15 min), NH4Cl, cold water and ethyl acetate added, stirred (10 min); organic layer separated, washed (cold water), set aside (overnight, room temp.); elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With n-butyllithium In diethyl ether; hexane byproducts: (C6H4Br)(CONC(CH3)2CH2); under N2, n-BuLi in hexane slowly added to a soln. of the organic compound, quenched with B(OMe)3; distilled (reduced pressure, -10°C), residue extracted (CH2Cl2),concentrated (-10°C), not isolated; (1)H NMR, (13)C NMR, MS; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
73% | With magnesium; triflic acid; HMPA In tetrahydrofuran; methanol; dichloromethane Ar-atmosphere; TfOH addn. (1 equiv.) to Bi-compd. and HMPA (2 equiv.) (0°C), stirring (2 h, room temp.); evapn., drying, dissolving (THF)and addn. to soln. of Grignard compd. (THF, from Mg and Br-deriv., -20. degree.C), stirring (15 min, warming); quenching with aq. NH4Cl (0°C), phase sepn., water phase extn. (benzene), org. phases grying (MgSO4), evapn. (vac.), crystn. (benzen/MeOH1/4); elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | With n-butyllithium In not given N2-atmosphere; addn. of BuLi (in hexane) to ligand precursor (in Et2O orTHF, not specified) at -78°C, stirring at -78°C for 30 mi n, dropwise addn. of stoich. amt. Ph3SnCl at -78°C, stirring at room temp. for 5 h; filtration, evapn., recrystn. (Et2O or Et2O/CH2Cl2=2:1, not specified); elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
43% | With n-butyllithium In not given N2-atmosphere; addn. of BuLi (in hexane) to ligand precursor (in Et2O orTHF, not specified) at -78°C, stirring at -78°C for 30 mi n, dropwise addn. of stoich. amt. HgCl2 at -78°C, stirring at room temp. for 5 h; filtration, evapn., recrystn. (Et2O or Et2O/CH2Cl2=2:1, not specified); elem. anal.; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With potassium carbonate In 1,2-dimethoxyethane; water for 20h; Heating; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With zinc(II) chloride In chlorobenzene for 24h; Reflux; | |
64% | With zinc(II) chloride In chlorobenzene Reflux; | |
With chlorobenzene; zinc(II) chloride |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In toluene at 110℃; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1.5h; Inert atmosphere; Stage #2: Triisopropyl borate In tetrahydrofuran; hexane at -78 - -15℃; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | at 170℃; for 0.25h; Microwave irradiation; Neat (no solvent); open vessel; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 20 - 64℃; Inert atmosphere; | |
90% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 60℃; for 3h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
69% | With palladium diacetate; bis[2-(diphenylphosphino)phenyl] ether; sodium t-butanolate In toluene at 20℃; for 120h; Reflux; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | With potassium phosphate; copper(l) iodide; <i>L</i>-proline In dimethyl sulfoxide at 110℃; for 14h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61.4% | With potassium phosphate; copper(l) iodide; triethylamine; <i>L</i>-proline In dimethyl sulfoxide at 110℃; for 14h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84.6% | With potassium phosphate; copper(l) iodide; <i>L</i>-proline In dimethyl sulfoxide at 110℃; for 14h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 20 - 64℃; for 12h; Inert atmosphere; | |
76% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 60℃; for 8h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 60℃; for 6h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 60℃; for 2h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 60℃; for 8h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 60℃; for 3h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
65% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 60℃; for 4h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
5% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 60℃; for 24h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In tetrahydrofuran; water at 20 - 64℃; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; Inert atmosphere; Stage #2: N-benzyl-1,2,3,4-tetrahydroquinoline-6-carbaldehyde In tetrahydrofuran; pentane at -78 - 0℃; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
91% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With tert.-butyl lithium In tetrahydrofuran; pentane at -78℃; for 2h; Inert atmosphere; Stage #2: C28H36N2O3 In tetrahydrofuran; pentane at -78 - 0℃; Inrtert atmosphere; Cooling with ice; Stage #3: trifluoroacetic acid Further stages; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 2 steps 1: magnesium; triflic acid; HMPA / tetrahydrofuran; dichloromethane; methanol 2: magnesium; triflic acid; HMPA / tetrahydrofuran; dichloromethane; methanol |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 3 steps 1: magnesium; triflic acid; HMPA / tetrahydrofuran; dichloromethane; methanol 2: magnesium; triflic acid; HMPA / tetrahydrofuran; dichloromethane; methanol 3: acetonitrile; dichloromethane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1: magnesium; triflic acid; HMPA / tetrahydrofuran; dichloromethane; methanol 2: magnesium; triflic acid; HMPA / tetrahydrofuran; dichloromethane; methanol 3: acetonitrile; dichloromethane 4: water; dichloromethane 5: water; dichloromethane 6: water; dichloromethane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Multi-step reaction with 6 steps 1: magnesium; triflic acid; HMPA / tetrahydrofuran; dichloromethane; methanol 2: magnesium; triflic acid; HMPA / tetrahydrofuran; dichloromethane; methanol 3: acetonitrile; dichloromethane 4: water; dichloromethane 5: water; dichloromethane 6: water; dichloromethane |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
78% | With potassium phosphate; copper(l) iodide; <i>L</i>-proline In dimethyl sulfoxide at 110℃; for 14h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium In tetrahydrofuran; hexane at -89℃; for 0.833333h; Stage #2: bis(p-methoxyphenyl)methanone In tetrahydrofuran; hexane at -89 - 20℃; for 16h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With 2,2,6,6-tetramethylpiperidinylmagnesium chloride In tetrahydrofuran at 25℃; for 2h; Schlenk technique; Inert atmosphere; Stage #2: With iodine In tetrahydrofuran at 25℃; for 12h; Schlenk technique; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
37% | With palladium (II) nitrate; silver nitrate; N-fluorobis(benzenesulfon)imide In acetonitrile at 80℃; for 24h; Inert atmosphere; Microwave irradiation; Sealed tube; | General Procedures for Fluorination General procedure: As a typical experiment, the oxazoline derivative 5 (0.5 mmol), NFSI (0.75mmol), Pd(NO3)2 (0.1 mmol), and AgNO3 (0.25mmol) were charged into an oven dried microwave reaction vial, equipped with a magnetic stirring bar and sealed. The reaction vial was evacuated and purged several times with nitrogen. Anhydrous acetonitrile (5 mL) was added, and the microwave vial purged several times with nitrogen. The microwave vial was placed in a heating block at 80 °C and reactants were allowed to stir for 24hr. After cooling to room temperature, the reaction mixture was filtered through a plug of silica, using ethyl acetate and then washed twice with 3% triethylamine in water solution, twice with brine and then the organic layerwas dried over MgSO4 and filtered. The organic layer was concentrated in vacuo and the residue and was analyzed by gas chromatography using dodecane as an internal standardto determine the conversion of the fluorinated product. The crude product was purified by silica gel column chromatography using an appropriate ratio of the eluent. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
1.422 g | With sodium hydroxide In ethanol at 25℃; for 0.5h; Inert atmosphere; | General Procedures for Preparations of Aryl-2-oxazolines General procedure: Aryl acid (10 mmol) was dissolved in 20 mL of dried methylene chloride and cooled to 0 °C; 5 drops of DMF was added to the suspension. Oxalyl chloride (12 mmol) was added drop-wise to the reaction mixture. The reaction was warmed to room temperature and stirred for 3 h. The solvent was removed in vacuo and the residue was dried for 1 h on high vacuum. The residue was dissolved in 15 mL of methylene chloride and added drop wise to a suspension of 2-amino-2-methyl-1-propanol (1.39 g, 12 mmol), triethylamine (2.02 g, 20 mmol) in 35 mL of methylene chloride at 0 oC. The reaction stirred for 3 hand was warmed to rt. The reaction was diluted with methylene chloride and washed once with dilute HCl and washed twice with brine. The organic layer was dried, (MgSO4) filtered, and concentrated in vacuo to give the crude amide intermediate. The crude amide intermediate (2.07 g 10 mmol) was dissolved in 50 mL of DCM and triethylamine(1.21 g, 12 mmol) was added. The reaction was stirred for 30 min at 0 oC. Mesyl chloride (1.37 g, 12 mmol) was added drop wise and the reaction warmed to room temperature and stirred for 3 h. The reaction was diluted with DCM and washed twice with dilute HCl and twice with brine. The organic layer was dried,(MgSO4), filtered, and concentrated in vacuo to give the crude mesylate intermediate. The crude mesylate product was purified via flash chromatography in a gradient of hexane ethyl acetate respectively. The purified product was then diluted in 20 mL of ethanol and sodium hydroxide (480 mg, 9.3 mmol) was added and the reaction was stirred for 30 min. The reaction mixture was diluted with ethyl acetate and washed 3 times with brine. The organic layer was dried over MgSO4 filtered and concentrated in vacuo to afford the product after flash chromatography. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
54% | Stage #1: diphenylphosphane With copper(l) iodide; N,N`-dimethylethylenediamine In toluene at 20℃; for 0.333333h; Stage #2: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With caesium carbonate In toluene for 6h; Sealed tube; Reflux; | |
54% | Stage #1: diphenylphosphane With copper(l) iodide In toluene at 20℃; for 0.166667h; Stage #2: With N,N`-dimethylethylenediamine In toluene for 0.166667h; Stage #3: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With caesium carbonate In toluene at 110℃; for 6h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: methyl p-toluene sulfinate In tetrahydrofuran; hexane at -78 - 20℃; for 3h; Inert atmosphere; | |
75% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: methyl p-toluene sulfinate In tetrahydrofuran; hexane at -78 - 0℃; for 2h; Inert atmosphere; | The General Procedure for (±)-SOX Ligand Synthesis SOX To an oven-dried round-bottom flask was added a stir bar, phenyloxazoline (5.0 mmol, 1.0 equiv), THF (25 ml, 0.2 M), and tetramethylethylenediamine (TMEDA, 5.5 mmol, 1.1 equiv). The reaction flask was cooled to -78°C. and n-butyllithium (1.6 M in hexane, 5.5 mmol, 1.1 equiv) was added dropwise. The reaction was stirred 20 minutes at -78°C. Subsequently, the methyl sulfinate (6.0 mmol, 1.2 equiv) was added as a solution in THF (12 ml, 0.5 M) dropwise. The reaction was stirred 1 hour at -78°C., then 1 hour at 0°C., then 1 hour at room temperature. The reaction was quenched with water. The mixture was diluted with diethyl ether, and the layers were separated. The aqueous layer was extracted with diethyl ether (20 mL3). The combined organic layers were dried over anhydrous MgSO4, filtered, and concentrated under reduced pressure. The crude residue was purified via flash column chromatography (0%=>20% acetone in hexanes) to afford the (±)-SOX ligand. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
84% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium; N,N,N,N,-tetramethylethylenediamine In tetrahydrofuran; hexane at -78℃; for 0.333333h; Inert atmosphere; Stage #2: methyl p-methoxybenzenesulphinate In tetrahydrofuran; hexane at -78 - 20℃; for 3h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
52% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium In diethyl ether; n-heptane at -78℃; for 1h; Inert atmosphere; Stage #2: 3-methoxynaphthalene-1-carbaldehyde In diethyl ether; n-heptane at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
21% | Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium In diethyl ether; n-heptane at -78℃; for 1h; Inert atmosphere; Stage #2: 4-methoxy-1-naphthaldehyde In diethyl ether; n-heptane at 20℃; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
Stage #1: 2-(2-bromo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole With n-butyllithium In diethyl ether at -78℃; for 2h; Inert atmosphere; Stage #2: C23H28N2OSi In diethyl ether at -78 - 20℃; Stage #3: With hydrogenchloride In water at 80℃; for 24h; | 3 Under the protection of argon, a 100 mL round bottom flask equipped with a magnetic stirrer was charged with bromooxazoline derivatives (7, 0.253 g, 1 mmol) and anhydrous ether (aldrich, 10 mL).-78 , stirring for 30 minutes, n-BuLi (Aldrich, 1.25mL, 1.6M inn-hexane, 2mmol) was slowly added dropwise to the reaction solution, after the dropwise addition,The reaction was continued for 2 hours at the same temperature. The ketone intermediate (6, 0.376 g, 1 mmol) was dissolved in anhydrous ether (Aldrich, 10 mL), and slowly added dropwise to the aforementioned reaction system at -78 ° C.After the dropwise addition, the reaction slowly rose to room temperature, and the reaction was stirred overnight at room temperature.Add 20 mL of water to the reaction bottle to quench the reaction, add 25 mL of dichloromethane,The organic layer was separated, the aqueous layer was extracted three times with dichloromethane, and the organic layers were combined,Wash once with 20mL water, once with 20mL saturated brine, and dry over anhydrous sodium sulfate.The solvent was removed by rotary evaporation, and the obtained crude product was used directly in the next reaction without purification.The above reaction crude product was dissolved in concentrated hydrochloric acid (aldrich, 20 mL, 0.24 mmol) and water (20 mL), and then heated to 80 ° C. and stirred for 24 h. After the reaction was completed, 20 mL of water, 40 mL of dichloromethane and 60 mL of ethyl acetate were added to the reaction system, and saturated sodium bicarbonate solution was added to neutralize the acidity. The organic layer was separated, the aqueous layer was extracted three times with dichloromethane, and the organic layers were combined, washed once with 20 mL of water, once with 20 mL of saturated saline, and dried over anhydrous sodium sulfate. The solvent was removed by rotary evaporation, and the resulting crude product was purified by silica gel column chromatography. The eluent was petroleum ether by volume: ethyl acetate = 5: 1, and a yellow solid was obtained with a yield of 65%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
54 %Spectr. | With dmap; [18F]-potassium fluoride; IPrCuOTf In N,N-dimethyl-formamide at 140℃; for 0.5h; Inert atmosphere; Glovebox; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
30 %Spectr. | With dmap; [1,3-bis(2,6-di-iso-propylphenyl)imidazol-2-ylidene]copper (I) fluoride In N,N-dimethyl-formamide at 140℃; for 21h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
56% | With 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate In toluene at 130℃; Schlenk technique; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
81% | With potassium fluoride; copper(l) iodide; tetraethylene glycol monododecyl ether; tetrabutyl-ammonium chloride; C34H34NO3PPdS In tetrahydrofuran; water at 55 - 60℃; for 18h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
45% | With potassium phosphate; copper(l) iodide In 1,4-dioxane at 110℃; for 1.5h; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | Stage #1: 4,5-dihydro-4,4-dimethyl-2-phenoxazole With di-sec-butylmagnesium In toluene at 25℃; for 1h; Stage #2: With bromine regioselective reaction; |
Tags: 32664-13-4 synthesis path| 32664-13-4 SDS| 32664-13-4 COA| 32664-13-4 purity| 32664-13-4 application| 32664-13-4 NMR| 32664-13-4 COA| 32664-13-4 structure
[ 339316-16-4 ]
(R)-2-(2-Bromophenyl)-4-methyl-4,5-dihydrooxazole
Similarity: 0.95
[ 154701-59-4 ]
(S)-2-(2-Bromophenyl)-4-methyl-4,5-dihydrooxazole
Similarity: 0.95
[ 32664-14-5 ]
2-(4-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.92
[ 51849-84-4 ]
2-(3-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.91
[ 337524-03-5 ]
2-(6-Bromonaphthalen-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.89
[ 339316-16-4 ]
(R)-2-(2-Bromophenyl)-4-methyl-4,5-dihydrooxazole
Similarity: 0.95
[ 154701-59-4 ]
(S)-2-(2-Bromophenyl)-4-methyl-4,5-dihydrooxazole
Similarity: 0.95
[ 32664-14-5 ]
2-(4-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.92
[ 51849-84-4 ]
2-(3-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.91
[ 337524-03-5 ]
2-(6-Bromonaphthalen-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.89
[ 339316-16-4 ]
(R)-2-(2-Bromophenyl)-4-methyl-4,5-dihydrooxazole
Similarity: 0.95
[ 154701-59-4 ]
(S)-2-(2-Bromophenyl)-4-methyl-4,5-dihydrooxazole
Similarity: 0.95
[ 32664-14-5 ]
2-(4-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.92
[ 51849-84-4 ]
2-(3-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.91
[ 337524-03-5 ]
2-(6-Bromonaphthalen-2-yl)-4,4-dimethyl-4,5-dihydrooxazole
Similarity: 0.89
Precautionary Statements-General | |
Code | Phrase |
P101 | If medical advice is needed,have product container or label at hand. |
P102 | Keep out of reach of children. |
P103 | Read label before use |
Prevention | |
Code | Phrase |
P201 | Obtain special instructions before use. |
P202 | Do not handle until all safety precautions have been read and understood. |
P210 | Keep away from heat/sparks/open flames/hot surfaces. - No smoking. |
P211 | Do not spray on an open flame or other ignition source. |
P220 | Keep/Store away from clothing/combustible materials. |
P221 | Take any precaution to avoid mixing with combustibles |
P222 | Do not allow contact with air. |
P223 | Keep away from any possible contact with water, because of violent reaction and possible flash fire. |
P230 | Keep wetted |
P231 | Handle under inert gas. |
P232 | Protect from moisture. |
P233 | Keep container tightly closed. |
P234 | Keep only in original container. |
P235 | Keep cool |
P240 | Ground/bond container and receiving equipment. |
P241 | Use explosion-proof electrical/ventilating/lighting/equipment. |
P242 | Use only non-sparking tools. |
P243 | Take precautionary measures against static discharge. |
P244 | Keep reduction valves free from grease and oil. |
P250 | Do not subject to grinding/shock/friction. |
P251 | Pressurized container: Do not pierce or burn, even after use. |
P260 | Do not breathe dust/fume/gas/mist/vapours/spray. |
P261 | Avoid breathing dust/fume/gas/mist/vapours/spray. |
P262 | Do not get in eyes, on skin, or on clothing. |
P263 | Avoid contact during pregnancy/while nursing. |
P264 | Wash hands thoroughly after handling. |
P265 | Wash skin thouroughly after handling. |
P270 | Do not eat, drink or smoke when using this product. |
P271 | Use only outdoors or in a well-ventilated area. |
P272 | Contaminated work clothing should not be allowed out of the workplace. |
P273 | Avoid release to the environment. |
P280 | Wear protective gloves/protective clothing/eye protection/face protection. |
P281 | Use personal protective equipment as required. |
P282 | Wear cold insulating gloves/face shield/eye protection. |
P283 | Wear fire/flame resistant/retardant clothing. |
P284 | Wear respiratory protection. |
P285 | In case of inadequate ventilation wear respiratory protection. |
P231 + P232 | Handle under inert gas. Protect from moisture. |
P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
Code | Phrase |
P301 | IF SWALLOWED: |
P304 | IF INHALED: |
P305 | IF IN EYES: |
P306 | IF ON CLOTHING: |
P307 | IF exposed: |
P308 | IF exposed or concerned: |
P309 | IF exposed or if you feel unwell: |
P310 | Immediately call a POISON CENTER or doctor/physician. |
P311 | Call a POISON CENTER or doctor/physician. |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell. |
P313 | Get medical advice/attention. |
P314 | Get medical advice/attention if you feel unwell. |
P315 | Get immediate medical advice/attention. |
P320 | |
P302 + P352 | IF ON SKIN: wash with plenty of soap and water. |
P321 | |
P322 | |
P330 | Rinse mouth. |
P331 | Do NOT induce vomiting. |
P332 | IF SKIN irritation occurs: |
P333 | If skin irritation or rash occurs: |
P334 | Immerse in cool water/wrap n wet bandages. |
P335 | Brush off loose particles from skin. |
P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
P337 | If eye irritation persists: |
P338 | Remove contact lenses, if present and easy to do. Continue rinsing. |
P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P342 | If experiencing respiratory symptoms: |
P350 | Gently wash with plenty of soap and water. |
P351 | Rinse cautiously with water for several minutes. |
P352 | Wash with plenty of soap and water. |
P353 | Rinse skin with water/shower. |
P360 | Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. |
P361 | Remove/Take off immediately all contaminated clothing. |
P362 | Take off contaminated clothing and wash before reuse. |
P363 | Wash contaminated clothing before reuse. |
P370 | In case of fire: |
P371 | In case of major fire and large quantities: |
P372 | Explosion risk in case of fire. |
P373 | DO NOT fight fire when fire reaches explosives. |
P374 | Fight fire with normal precautions from a reasonable distance. |
P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
P378 | |
P380 | Evacuate area. |
P381 | Eliminate all ignition sources if safe to do so. |
P390 | Absorb spillage to prevent material damage. |
P391 | Collect spillage. Hazardous to the aquatic environment |
P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
Home
* Country/Region
* Quantity Required :
* Cat. No.:
* CAS No :
* Product Name :
* Additional Information :