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Chemical Structure| 326894-74-0 Chemical Structure| 326894-74-0

Structure of 326894-74-0

Chemical Structure| 326894-74-0

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Product Details of [ 326894-74-0 ]

CAS No. :326894-74-0
Formula : C6H3F3IN
M.W : 272.99
SMILES Code : FC(C1=CC(I)=NC=C1)(F)F
MDL No. :MFCD13189353

Safety of [ 326894-74-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331
Precautionary Statements:P261-P264-P270-P271-P280-P302+P352-P304+P340-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 326894-74-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 326894-74-0 ]

[ 326894-74-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 326894-74-0 ]
  • [ 57090-88-7 ]
  • 1-(4-(trifluoromethyl)pyridin-2-yl)-1H-imidazole-4-carbonitrile [ No CAS ]
YieldReaction ConditionsOperation in experiment
With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; In N,N-dimethyl-formamide; at 100℃; for 2h; General procedure: A solution of <strong>[57090-88-7]4-cyano-1H-imidazole</strong> (1000 mg, 10.74 mmol), 4-iodo -2-(trifluoromethyl)pyridine (3800 mg,14 mmol), (1R,2R)-N1,N2-dimethyl cyclohexane -1,2-diamine (150 mg, 1.07 mmol), CuI (200 mg, 1.07 mmol) and Cs2CO3 (7000 mg, 21.5 mmol) in 20 mL anhydrous DMF was stirred at 100 oC for 2 hours. The reaction mixture was cooled to room temperature and poured into 200 mL water. The mixture was extracted with ethyl acetate (80 mL*3). The organic layer were combined, washed by brine, dried by Na2SO4 and evaporated. The crude product was purified by silica flash column to afford compound 2 as white solid(1.5 g, 59percent yield).
 

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