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Chemical Structure| 3291-03-0 Chemical Structure| 3291-03-0

Structure of 3291-03-0

Chemical Structure| 3291-03-0

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Product Details of [ 3291-03-0 ]

CAS No. :3291-03-0
Formula : C10H14N2O4
M.W : 226.23
SMILES Code : O=C(NN)C1=CC(OC)=C(OC)C(OC)=C1
MDL No. :MFCD00014758

Safety of [ 3291-03-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 3291-03-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3291-03-0 ]

[ 3291-03-0 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 92-55-7 ]
  • [ 3291-03-0 ]
  • 5-nitrofurfurylidene 2-(3,4,5-trimethoxybenzydrazide) [ No CAS ]
  • 2
  • [ 10406-06-1 ]
  • [ 3291-03-0 ]
  • [ 1252802-30-4 ]
  • 3
  • [ 33985-71-6 ]
  • [ 3291-03-0 ]
  • N'-((1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)methylene)-3,4,5-trimethoxybenzhydrazide [ No CAS ]
YieldReaction ConditionsOperation in experiment
73% With trifluoroacetic acid; In chloroform; for 4h;Reflux; Inert atmosphere; General procedure: Aldehyde 2 (1 mmol) and the corresponding hydrazide 3 (1mmol) were dissolved in CHCl3 (10 mL). Trifluoroacetic acid (a few drops) was added and the resulted solution heated to reflux for 4 h. After cooling, the solvent was removed in vacuum and the residue was washed with cold diethyl ether. The product was further used without any other purification.
  • 4
  • [ 3291-03-0 ]
  • [ 143982-40-5 ]
  • (E)-N'-((imidazo[1,2-a]pyrimidin-2-yl)methylene)-3,4,5-trimethoxybenzohydrazide [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% In ethanol; for 1.0h;Reflux; General procedure: Aromatic/heteroaromatic aldehydes a-l(1.0 mmol) was added to ethanol (2 mL) containingcompound 3 (100 mg, 0.40 mmol) and heated toreux point for 1h. The solids obtained was flteredand slurred with ethanol (1mL) followed by n-Hexaneto get the hydrazones 4a-l .
  • 5
  • [ 103854-64-4 ]
  • [ 3291-03-0 ]
  • C21H21N3O5 [ No CAS ]
YieldReaction ConditionsOperation in experiment
In ethanol; at 80℃; for 3h; General procedure: 8-Methoxyquinoline-2-carbaldehyde (25, 0.534 mmol) was refluxedwith various substituted acylhydrazines (0.587 mmol, 1.1 eq) in ethanol(5-10 mL) to get acyl hydrazides of 8-hydroxyquinoline. After completionof reaction, quinoline acyl hydrazides were found as precipitateson cooling to -15 C. Precipitates were washed with coldethanol and dried under vacuum. These acyl hydrazides were used directlyfor one pot synthesis of 2,5-disubstituted-1,3,4-oxadiazole usingiodine/K2CO3 catalysed oxidative cyclization. To the acyl hydrazides(1.0 eq) in DMSO (5-10 mL), K2CO3 (3.0 eq) and iodine (1.2 eq) wereadded in sequence and refluxed at 110 C. After the completion, thereaction mixture was cooled and saturated solution of sodium thiosulfatewas added. The precipitates were collected and dried under highvacuum to get the respective compounds (33-50).
  • 6
  • [ 3291-03-0 ]
  • [ 143982-40-5 ]
  • N'-((imidazo[1,2-a] pyrimidin-2-yl)methylene)-3,4,5-trimethoxybenzohydrazide [ No CAS ]
YieldReaction ConditionsOperation in experiment
72% In ethanol; for 5.0h;Reflux; General procedure: To a stirred solution of compound 3 (100 mg, 0.30 mmol) in ethanol was added corresponding benzohydrazides (1.0 mmol) and refluxed for 5 h. The reaction medium was poured into water and extracted with ethyl acetate. The organic layer was washed with water followed by brine solution, dried over anhydrous sodium sulphate, filtered and concentrated under reduced pressure, to obtain the pure compounds.
 

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