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[ CAS No. 332-26-3 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 332-26-3
Chemical Structure| 332-26-3
Structure of 332-26-3 * Storage: {[proInfo.prStorage]}
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Product Details of [ 332-26-3 ]

CAS No. :332-26-3 MDL No. :MFCD00039475
Formula : C8H4F3NS Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 203.18 Pubchem ID :-
Synonyms :

Safety of [ 332-26-3 ]

Signal Word:Danger Class:6.1
Precautionary Statements:P261-P264-P270-P271-P280-P301+P310+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501 UN#:2811
Hazard Statements:H301-H315-H319-H335-H335 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 332-26-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 332-26-3 ]

[ 332-26-3 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 332-26-3 ]
  • [ 330-17-6 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride at 140℃;
  • 3
  • [ 2923-18-4 ]
  • [ 126747-14-6 ]
  • [ 332-26-3 ]
YieldReaction ConditionsOperation in experiment
20% With potassium phosphate; 1,10-Phenanthroline; copper(I) thiocyanate; sulfur; silver carbonate In N,N-dimethyl-formamide at 130℃; for 24h; Inert atmosphere; Sealed tube; Glovebox; 4.2. General procedure for synthesis of aryl trifluoromethylthioethers General procedure: In a glovebox, to a test tube equipped with a magnetic stir bar, aryl boronic acid 1 (0.2 mmol), CuSCN (24.1 mg, 0.2 mmol, 1 equiv), 1,10-phenanthroline (36.0 mg, 0.2 mmol, 1 equiv), S8 (19.2 mg, 0.6 mmol, 3.0 equiv), CF3CO2Na (136 mg, 1.0 mmol, 5 equiv), Ag2CO3 (110 mg, 0.4 mmol, 2.0 equiv), K3PO4 (127 mg, 0.6 mmol, 3.0 equiv), and DMF(4 mL) were added. The vessel was sealed with a septum and taken out from the glovebox. The mixture was stirred vigorously at 130 °C for 24 h. Phenyl trifluoromethyl sulfide (35.6 mg, 0.2 mmol) was added as an internal standard, and the yield of the crude reaction was measured by 19F NMR before workup. The reaction solution was filtered through Celite on silica and the filter cake was washed with diethyl ether. The filtrate was then washed with brine and concentrated. The residue was purified by silica gel column chromatography with petroleum ether to provide pure aryl trifluoromethyl thioether.
  • 4
  • [ 122148-91-8 ]
  • [ 2923-16-2 ]
  • [ 332-26-3 ]
  • 5
  • [ 1413732-47-4 ]
  • [ 126747-14-6 ]
  • [ 332-26-3 ]
YieldReaction ConditionsOperation in experiment
82% With oxygen; In 1-methyl-pyrrolidin-2-one; at 20.0℃; for 1.0h; General procedure: Arylboronic acid 2 (0.12 mmol) and (bpy)Cu(SCF3) 1 (0.1 mmol) were added to a Schlenk flask fitted with magnetic stir bar and O2 balloon. The flask was evacuated and back filled with O2. The solvent NMP (2.0 mL) was added by syringe at room temperature and the solution was stirred for 1 h. For the products reported with isolated yields (3a, 3k, 3l, 3m, 3n, 3o, 3p, 3q, 3r, 3s, 3t, 3u and 3w), the reaction mixture was diluted with EtOAc, then washed with water and brine. The organic phase was dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated under reduced pressure and the residue was purified by flash chromatography on silica gel (n-hexane/ethyl acetate gradient) to afford the desired compounds. Gram-scale synthesis of compound 5 was prepared following the similar procedure. The relatively volatile products (3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j and 3v) were not isolated and their yields were determined by 19F NMR measurement in CDCl3 of the reaction mixture. For the products reported with 19F NMR yields, PhOCF3 (1.0 equiv) was added to the reaction mixture as internal standard added after the reaction completed. The reaction mixture was purified by flash chromatography on silica gel (pentane/diethyl ether gradient) to afford the desired compounds.
  • 6
  • [ 15223-20-8 ]
  • [ 873-74-5 ]
  • [ 332-26-3 ]
YieldReaction ConditionsOperation in experiment
59% General procedure: To a flame-dried flask under N2 atmosphere equipped with a magneticstir bar were added 2 (153.8 mg, 0.6 mmol, 3 equiv), arenediazonium salt 1 (0.2 mmol, 1.0 equiv), [Ru(phen)3Cl2] (7.13 mg, 0.01 mmol, 5 mol%), and anhyd DMSO (2 mL). The reaction mixture was stirred at 25 C under white LED irradiation for 16 h. Conversion was checked by 19F NMR with PhOCF3 as internal standard. The mixture was partitioned between Et2O and H2O. The aqueous layer was extracted with Et2O and the combined organic layers were dried (MgSO4), filtered, and concentrated to dryness. The crude residue was purified by chromatography to afford the desired product 3. Note: As the products are very volatile, solvents must be carefully removed.
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