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[ CAS No. 332366-57-1 ] {[proInfo.proName]}

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Cat. No.: {[proInfo.prAm]}
3d Animation Molecule Structure of 332366-57-1
Chemical Structure| 332366-57-1
Chemical Structure| 332366-57-1
Structure of 332366-57-1 * Storage: {[proInfo.prStorage]}
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Quality Control of [ 332366-57-1 ]

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Product Details of [ 332366-57-1 ]

CAS No. :332366-57-1 MDL No. :MFCD07644510
Formula : C9H6BrNO Boiling Point : -
Linear Structure Formula :- InChI Key :XKLBNOHKHRAXKK-UHFFFAOYSA-N
M.W :224.05 Pubchem ID :12403680
Synonyms :

Calculated chemistry of [ 332366-57-1 ]

Physicochemical Properties

Num. heavy atoms : 12
Num. arom. heavy atoms : 10
Fraction Csp3 : 0.0
Num. rotatable bonds : 0
Num. H-bond acceptors : 1.0
Num. H-bond donors : 1.0
Molar Refractivity : 52.27
TPSA : 32.86 Ų

Pharmacokinetics

GI absorption : High
BBB permeant : Yes
P-gp substrate : No
CYP1A2 inhibitor : Yes
CYP2C19 inhibitor : No
CYP2C9 inhibitor : No
CYP2D6 inhibitor : No
CYP3A4 inhibitor : No
Log Kp (skin permeation) : -6.77 cm/s

Lipophilicity

Log Po/w (iLOGP) : 1.79
Log Po/w (XLOGP3) : 1.27
Log Po/w (WLOGP) : 2.29
Log Po/w (MLOGP) : 1.56
Log Po/w (SILICOS-IT) : 3.26
Consensus Log Po/w : 2.03

Druglikeness

Lipinski : 0.0
Ghose : None
Veber : 0.0
Egan : 0.0
Muegge : 0.0
Bioavailability Score : 0.55

Water Solubility

Log S (ESOL) : -2.65
Solubility : 0.506 mg/ml ; 0.00226 mol/l
Class : Soluble
Log S (Ali) : -1.56
Solubility : 6.18 mg/ml ; 0.0276 mol/l
Class : Very soluble
Log S (SILICOS-IT) : -4.47
Solubility : 0.00764 mg/ml ; 0.0000341 mol/l
Class : Moderately soluble

Medicinal Chemistry

PAINS : 0.0 alert
Brenk : 0.0 alert
Leadlikeness : 1.0
Synthetic accessibility : 1.56

Safety of [ 332366-57-1 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 332366-57-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 332366-57-1 ]

[ 332366-57-1 ] Synthesis Path-Downstream   1~51

  • 1
  • [ 541-41-3 ]
  • [ 145369-94-4 ]
  • [ 332366-40-2 ]
  • 3
  • [ 187278-01-9 ]
  • [ 145369-94-4 ]
YieldReaction ConditionsOperation in experiment
73% With diphenylether; at 245 - 250℃; for 0.25h;Inert atmosphere; A solution of Meldrum's acid (1) (32.4 g, 225.0 mmol) in trimethyl orthoformate (250 mL) was stirred and heated at reflux for 3 h under N2 to give 2. The solution was allowed to cool to ~50 C, and 4-bromoaniline (25.8 g, 150.0 mmol) in trimethyl orthoformate (80 mL) was added dropwise. The reaction mixture was heated at reflux for 2 h. After removal of the solvent in vacuo, the residue was diluted with hexanes, filtered, and the solid was washed with hexanes and dried to give Meldrum's acid derivative 3 as a yellow solid. Compound 3 was added slowly in small portions (~1.0 g each) to preheated (245 C) Ph2O (500 mL). Caution not to perform this addition too rapidly must be taken as gas violently evolves. The reaction mixture was stirred and heated at 250 C for 15 min, then allowed to cool to room temperature (rt) and diluted with hexanes, filtered. The solid was washed with hexanes, then 30% Et2O/hexanes. The crude product was purified by silica gel column chromatography (16:1-10:1 CH2Cl2/MeOH) to afford 4 (24.6 g, 73%) as a pale brown solid, mp 282-284 C (lit30 282-284 C). 1H NMR (DMSO-d6) delta 11.93 (br s, 1H, NH), 8.17 (d, J = 2.0 Hz, 1H, Ar-H), 7.96 (dd, J = 7.5, 6.0 Hz, 1H), 7.79 (dd, J = 9.0, 2.5 Hz, 1H, Ar-H), 7.53 (d, J = 8.5 Hz, 1H), 6.08 (d, J = 2.5 Hz, 1H, Ar-H).
In diphenylether; pentane;Reflux; Step 2: 6-bromo-1,4-dihydroquinolin-4-one (160b) Compound (160a) (535 mg, 1.64 mmol) was dissolved in hot diphenyl ether (10 mL) and heated under reflux for 30 minutes until the formation of gaseous products ceased. After cooling, pentane (8 mL) was added and the mixture was stirred 48 hours at room temperature. The precipitate was isolated by filtration and washed with pentane to afford compound (160b) (258 mg, 1.15 mmol, 70%).
In 1,2-dichloro-benzene; at 188℃; for 3.5h; 5- [(4-Bromophenylamino) methylene] -2,2-dimethyl-1,3-dioxane-4,6-dione (50 g,15411111101) was added to a 1-liter three-necked flask equipped with o-dichlorobenzene (500111, and the reaction was heated to 188 (reaction time 3.5 hoursSlowly cooled to 0 and stirred for 3 hours, filtered and the residue was washed with methyl tert-butyl ether (100 ml) to give a brown solid(30.6 g, 87%) as a crude product directly for the next step.
  • 5
  • [ 15568-85-1 ]
  • [ 106-40-1 ]
  • [ 145369-94-4 ]
YieldReaction ConditionsOperation in experiment
27% In diphenylether; biphenyl; at 80 - 220℃; for 4h; Diphenyl ether (80 ml) was added to 4-bromoaniline (4.5 g) and 5-(methoxymethylene)-2,2-dimethyl-1,3-dioxan-4,6-dione (5.4 g), and the mixture was stirred at 80C for one hr. Biphenyl (24.2 g) was added thereto, and the mixture was stirred at 220C for 3 hr. The reaction mixture was cooled to room temperature, and diethyl ether was added to the cooled mixture. The precipitated crystal was collected by filtration and was washed with diethyl ether. The residue was purified by column chromatography with a hexane-acetone system to give 6-bromoquinolone (1.57 g, yield 27%). Thionyl chloride (5 ml) and a minor amount of dimethylformamide were added to 6-bromoquinolone (1.6 g), and the mixture was stirred under reflux for 3 hr. The reaction mixture was added to a saturated aqueous sodium bicarbonate solution under ice cooling, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography with a hexane-ethyl acetate system to give 6-bromo-4-chloroquinoline (1.43 g, yield 85%).
  • 6
  • [ 145369-94-4 ]
  • [ 65340-70-7 ]
YieldReaction ConditionsOperation in experiment
92.6% With phosphorus trichloride; In toluene; for 2h;Reflux; willL0g (44.63 mol) of 6-bromoquinolin-4 (1H) -one, 100 ml of toluene and 12.25 g (89.26 mol) of phosphorus trichloride were added to a 250 ml three-necked flask and heated to reflux for 2 hours. , Dried and dried. The solid was beaten with ether (100 ml), filtered and dried to give a yellow powder (yield 92.6%).
85% With thionyl chloride;N,N-dimethyl-formamide; for 3h;Heating / reflux; Diphenyl ether (80 ml) was added to 4-bromoaniline (4.5 g) and 5-(methoxymethylene)-2,2-dimethyl-1,3-dioxan-4,6-dione (5.4 g), and the mixture was stirred at 80C for one hr. Biphenyl (24.2 g) was added thereto, and the mixture was stirred at 220C for 3 hr. The reaction mixture was cooled to room temperature, and diethyl ether was added to the cooled mixture. The precipitated crystal was collected by filtration and was washed with diethyl ether. The residue was purified by column chromatography with a hexane-acetone system to give 6-bromoquinolone (1.57 g, yield 27%). Thionyl chloride (5 ml) and a minor amount of dimethylformamide were added to 6-bromoquinolone (1.6 g), and the mixture was stirred under reflux for 3 hr. The reaction mixture was added to a saturated aqueous sodium bicarbonate solution under ice cooling, and the mixture was extracted with ethyl acetate. The ethyl acetate layer was washed with water and was dried over anhydrous sodium sulfate. The solvent was removed by distillation under the reduced pressure, and the residue was purified by column chromatography with a hexane-ethyl acetate system to give 6-bromo-4-chloroquinoline (1.43 g, yield 85%).
70% With trichlorophosphate; In N,N-dimethyl-formamide; for 2h;Reflux; A mixture of 4 (17.0 g, 131.5 mmol), POCl3 (180 mL) and anhydrous DMF (18 mL) was stirred and heated at reflux for 2 h. After removal of POCl3, the residue was poured into ice water and extracted with EtOAc. The combined organic layers were washed with saturated aqueous NaHCO3, brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The crude product was purified by silica gel column chromatography (4:1 hexanes/EtOAc) to afford 5 (12.8 g, 70%) as a white solid, mp 111-112 C (lit31 111-112 C). 1H NMR (CDCl3) delta 8.79 (d, J = 5.0 Hz, 1H, Ar-H), 8.40 (d, J = 2.5 Hz, 1H, Ar-H), 8.00 (d, J = 9.0 Hz, 1H, Ar-H), 7.84 (dd, J = 9.0, 2.0 Hz, 1H, Ar-H), 7.52 (d, J = 5.0 Hz, 1H, Ar-H).
  • 7
  • [ 79-22-1 ]
  • [ 145369-94-4 ]
  • [ 1104378-66-6 ]
  • 8
  • [ 96-32-2 ]
  • [ 145369-94-4 ]
  • [ 1149374-93-5 ]
YieldReaction ConditionsOperation in experiment
With potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 3h; A mixture of 6-bromo-1H-quinolin-4-one (0.50 g), lambda/,lambda/-dimethylformamide (10 mL) and potassium carbonate (0.34 g) was treated with methyl bromoacetate (0.21 mL), and the resulting mixture was stirred at 60 0C for 3 hours. The mixture was <n="19"/>concentrated under reduced pressure and the residue partitioned between dichloromethane and water. The organic phase was washed with water, dried over magnesium sulfate and concentrated under reduced pressure. The residue was purified by flash chromatography on silica gel, eluting with ethyl acetate to afford the title compound as a yellow solid (0.053 g).MS: ESI (+ve) (Method B): 297 (M+H)+, Retention time 2.1 min.
  • 10
  • [ 1320361-74-7 ]
  • [ 145369-94-4 ]
YieldReaction ConditionsOperation in experiment
45% In diphenylether; at 280℃; for 0.166667h;Microwave irradiation; A mixture of ethyl 3-(4-bromoanilino)propenoate (100 mg, 0.37 mmol) and diphenyl ether (1.6 mL) was exposed to microwaves irradiation at 280 C for 10 min. The brown solid which formed was washed with diethyl ether to give the title compound 3 (44 mg, 45%) as a brown solid. Rf 0.34 (CH2Cl2/MeOH, 9/1); mp 286 C; 1H NMR (400 MHz, (CD3)2SO): delta 11.93 (s, 1H), 8.15 (d, J = 4.0 Hz, 1H), 7.95 (d, J = 8.0 Hz, 1H), 7.78 (dd, Jortho = 8.0 Hz, Jmeta = 4.0 Hz, 1H), 7.52 (d, J = 8.0 Hz, 1H), 6.08 (d, J = 8.0 Hz, 1H); 13C NMR (100 MHz, (CD3)2SO): delta 176.1, 140.3, 139.4, 134.8, 127.6, 121.4, 116.2, 109.5; IR (Nujol): n 1618 cm-1; MS: m/z (M+ + 1) 224.
53 g In diphenylether; at 220℃; for 10h; 80 g of crude 3- (4-bromobenzene ethyl acrylate) was dissolved in 150 ml of diphenyl ether and slowly dropped at 220 CContaining diphenyl ether (400 ml) in a 1 L three-necked flask. After 10 hours of reaction, the point of raw material disappeared. The reaction solution was cooled to room temperatureAnd then poured into 1500ml petroleum ether, allowed to stand overnight after the filter, filter residue with ethyl acetate (150ml) beating, filtration, drying53 g of 6-bromoquinolin-4 (1H) -one (yield 81.06%).
  • 11
  • [ 145369-94-4 ]
  • [ 1260886-58-5 ]
YieldReaction ConditionsOperation in experiment
93% With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20℃; for 0.05h; N-iodosuccinimide (3 g, 13.4 mmol) was added to a solution of 3 (2 g, 8.92 mmol) in dry DMF (27 mL) maintained under stirring at room temperature. After 3 min, the mixture was diluted with water and the precipitate which formed was filtered and washed with water and diethyl ether to afford 2 (2.9 g, 93%) as a withe solid. Rf 0.72 (CH2Cl2/MeOH, 9/1); mp >290 C; 1H NMR (200 MHz, (CD3)2SO): delta 12.27 (s, 1H), 8.47 (s, 1H), 8.10 (d, J = 2.4 Hz, 1 H), 7.79 (dd, Jortho = 9.0 Hz, Jmeta = 2.4 Hz, 1H), 7.47 (d, J = 8.9 Hz, 1H); 13C NMR (100 MHz, (CD3)2SO) delta 172.4, 145.6, 138.9, 135.1, 128.0, 124.1, 121.6, 117.0, 81.3; IR (Nujol): n = 1614 cm-1; MS: m/z (M+ + 1) = 350.
  • 12
  • [ 145369-94-4 ]
  • [ 1086062-66-9 ]
  • 15
  • [ 75-03-6 ]
  • [ 145369-94-4 ]
  • 6-bromo-1-ethyl-1,4-dihydroquinolin-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
50% With potassium carbonate; In N,N-dimethyl-formamide; at 80℃;Inert atmosphere; Under argon atmosphere, ethyl iodide (0.23 mL, 2.85 mmol) was added to a solution of compound (160b) (255 mg, 1.14 mmol) and potassium carbonate (472 mg, 3.42 mmol) in DMF (2 mL). The mixture was heated at 80 C overnight. The middle was poured over ice and the aqueous layer was extracted with ethyl acetate. The organic layer was washed with water, brine, dried over sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (DCM/MeOH 95/5) to give compound (160c) (144 mg, 0.57 mmol, 50%).
  • 16
  • [ 100-39-0 ]
  • [ 145369-94-4 ]
  • N-benzyl-6-bromo-4-quinolone [ No CAS ]
  • 17
  • [ 145369-94-4 ]
  • 3-(6-bromo-1-methyl-4-oxo-1,2,3,4-tetrahydroquinolin-2-yl)propanenitrile [ No CAS ]
  • 18
  • [ 486422-68-8 ]
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)quinolin-4(1H)-one [ No CAS ]
  • 20
  • [ 145369-94-4 ]
  • 4-((4-(4-chloroquinolin-6-yl)phenyl)sulfonyl)morpholine [ No CAS ]
  • 21
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)-N-phenylquinolin-4-amine [ No CAS ]
  • 22
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)-N-(pyridin-2-yl)quinolin-4-amine [ No CAS ]
  • 23
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)-N-(pyridin-3-yl)quinolin-4-amine [ No CAS ]
  • 24
  • [ 145369-94-4 ]
  • N-(1H-benzo[d][1,2,3]triazol-5-yl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine [ No CAS ]
  • 25
  • [ 145369-94-4 ]
  • 3,5-dimethyl-N-(6-(4-(morpholinosulfonyl)phenyl)quinolin-4-yl)isoxazol-4-amine [ No CAS ]
  • 26
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)-N-(6-nitropyridin-3-yl)quinolin-4-amine [ No CAS ]
  • 27
  • [ 145369-94-4 ]
  • N-(2-methoxypyrimidin-5-yl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine [ No CAS ]
  • 28
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)-N-(pyridazin-4-yl)quinolin-4-amine [ No CAS ]
  • 29
  • [ 145369-94-4 ]
  • N-(1-ethyl-1H-pyrazol-5-yl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine [ No CAS ]
  • 30
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)-N-(pyrimidin-4-yl)quinolin-4-amine [ No CAS ]
  • 31
  • [ 145369-94-4 ]
  • N-(4-methoxy-3-methylphenyl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine [ No CAS ]
  • 32
  • [ 145369-94-4 ]
  • 5-ethyl-N-(6-(4-(morpholinosulfonyl)phenyl)quinolin-4-yl)-1,3,4-thiadiazol-2-amine [ No CAS ]
  • 33
  • [ 145369-94-4 ]
  • 5-methyl-N-(6-(4-(morpholinosulfonyl)phenyl)quinolin-4-yl)thiazol-2-amine [ No CAS ]
  • 34
  • [ 145369-94-4 ]
  • 5-cyclopropyl-N-(6-(4-(morpholinosulfonyl)phenyl)quinolin-4-yl)-1,3,4-thiadiazol-2-amine [ No CAS ]
  • 35
  • [ 145369-94-4 ]
  • 3-methyl-N-(6-(4-(morpholinosulfonyl)phenyl)quinolin-4-yl)isothiazol-5-amine [ No CAS ]
  • 36
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)-N-(pyrazin-2-yl)quinolin-4-amine [ No CAS ]
  • 37
  • [ 145369-94-4 ]
  • 5-((6-(4-(morpholinosulfonyl)phenyl)quinolin-4-yl)amino)pyrazine-2-carbonitrile [ No CAS ]
  • 38
  • [ 145369-94-4 ]
  • N-(5-chloropyrimidin-2-yl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine [ No CAS ]
  • 39
  • [ 145369-94-4 ]
  • 6-(4-(morpholinosulfonyl)phenyl)-N-(pyridin-4-yl)quinolin-4-amine [ No CAS ]
  • 40
  • [ 145369-94-4 ]
  • N-(3-chloro-4-methoxyphenyl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine [ No CAS ]
  • 41
  • [ 145369-94-4 ]
  • N-(5,6-dimethyl-1,2,4-triazin-3-yl)-6-(4-(morpholinosulfonyl)phenyl)quinolin-4-amine [ No CAS ]
  • 42
  • [ 145369-94-4 ]
  • 3-methyl-N-(6-(4-(morpholinosulfonyl)phenyl)quinolin-4-yl)isoxazol-5-amine [ No CAS ]
  • 43
  • [ 98948-95-9 ]
  • [ 145369-94-4 ]
YieldReaction ConditionsOperation in experiment
96% In diphenylether; for 1h;Reflux; 6-bromo-4-hydroxy-3-quinolinecarboxylic acid (2.5 g, 9.3 mmol) was added to diphenyl ether (30 mL) and the reaction was heated at reflux for 1 hour. The reaction solution was cooled, poured into n-hexane (200 mL), filtered, washed with n-hexane and dried to give 2.0 g (96%) of whiteColor solid.
  • 44
  • [ 145369-94-4 ]
  • 3-(4-(4-amino-piperidin-1-yl)-3-(3,5-difluoro-phenyl)-quinolin-6-yl)-2-hydroxy-benzonitrile dihydrochloride [ No CAS ]
  • 45
  • [ 145369-94-4 ]
  • C26H27ClN4O3 [ No CAS ]
  • 46
  • [ 145369-94-4 ]
  • 3-(4-(4-amino-piperidin-1-yl)-3-(3,5-difluoro-phenyl)-quinolin-6-yl)-2-hydroxy-benzonitrile [ No CAS ]
  • 47
  • [ 145369-94-4 ]
  • [ 857762-32-4 ]
YieldReaction ConditionsOperation in experiment
78% With N-chloro-succinimide; acetic acid; at 50℃; for 8h; N-Chlorosuccinimide (377 g, 1.05 equiv) was added to a suspension of <strong>[145369-94-4]6-bromoquinolin-4(1H)-one</strong> (Compound A-I, 600 g, 1 equiv) in acetic acid (12 L, 20 vol) at RT. The reaction was then heated to 50 C. and stirred for 8 h. The reaction was cooled to 20 C., filtered, successively washed with AcOH (1.8 L, 3 vol), water (2.4 L, 4 vol), and MTBE (1.2 L, 2 vol), and dried under vacuum on a filter to afford crude Compound A-II. The crude material was stirred in MTBE (7.2 L, 12 vol) for 2 h, filtered, washed with MTBE (0.6 L, 1 vol) and dried under vacuum to afford 541 g (78%) of Compound A-II as an off white solid, which was determined to be 97.35% pure (HPLC-AUC).
  • 48
  • [ 145369-94-4 ]
  • {1-[6-(3-cyano-2-hydroxyphenyl)-3-(3,5-difluorophenyl)quinolin-4-yl]piperidin-4-yl}carbamic acid tert-butyl ester [ No CAS ]
  • 49
  • C36H57FN2O12 [ No CAS ]
  • [ 145369-94-4 ]
  • C43H60FN3O12 [ No CAS ]
YieldReaction ConditionsOperation in experiment
8.66% Alternatively, step f may be a seventh compound as shown in 7d (2-fluoro-3-O-decladate-3-carbonyl-6-O-[3-[6'-(1', Preparation of 4'-dihydro-4'-oxoquinolyl]]-E-prop-2-enyl]erythromycin A 9-O-methylindole-11,12-cyclocarbonateThe sixth compound (0.300 g, 0.412 mmol), palladium acetate (0.0278 g, 0.124 mmol), tris(o-methylphenyl)phosphorate (0.0752 g, 0.247 mmol),<strong>[145369-94-4]6-bromo-3-quinolinecarboxylic acid-4-ol</strong> (0.221 g, 0.824 mmol),Triethylamine (5 mL, 36.071 mmol) was dissolved in 5 mL of acetonitrile and placed in a pressure bottle.Argon was replaced 8 times and sealed. The reaction was carried out at 60 C for 1 h, and then the temperature was raised to 90 C and stirred for 48 h. After the reaction is completed, 20 ml of ethyl acetate is added, washed 3 times with water, once with saturated sodium chloride solution, and then separated by liquid separation.Machine layer. After that, the product was dissolved in methanol, refluxed at 65 C for 1-1.5 h, and the reaction was monitored by thin layer chromatography to give a crude product. columnChromatography (100-200 mesh silica gel, mobile phase is V (dichloromethane): V (ethanol): V (ammonia) = 10:0.5:0.1), as describedThe seventh compound shown in 7d, 29.6 mg (0.0357 mmol, yield 8.66%).
  • 50
  • [ 1666-13-3 ]
  • [ 332366-57-1 ]
  • C15H10BrNOSe [ No CAS ]
YieldReaction ConditionsOperation in experiment
91% With potassium iodide In dimethyl sulfoxide at 20℃; for 12h; Electrochemical reaction; Green chemistry;
  • 51
  • [ 2033-24-1 ]
  • [ 106-40-1 ]
  • [ 332366-57-1 ]
YieldReaction ConditionsOperation in experiment
Stage #1: cycl-isopropylidene malonate With trimethyl orthoformate at 110℃; for 2h; Inert atmosphere; Schlenk technique; Stage #2: 4-bromo-aniline at 110℃; for 2h; Inert atmosphere; Schlenk technique; Stage #3: In diphenylether at 250℃; for 1h; Inert atmosphere; Schlenk technique;
Same Skeleton Products
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