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Chemical Structure| 3334-05-2 Chemical Structure| 3334-05-2

Structure of 3334-05-2

Chemical Structure| 3334-05-2

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Product Details of [ 3334-05-2 ]

CAS No. :3334-05-2
Formula : C4H8OS
M.W : 104.17
SMILES Code : OC1CSCC1
MDL No. :MFCD00121060
InChI Key :BJYXNFYVCZIXQC-UHFFFAOYSA-N
Pubchem ID :315652

Safety of [ 3334-05-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H317-H319
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 3334-05-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3334-05-2 ]

[ 3334-05-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 3334-05-2 ]
  • [ 21286-54-4 ]
  • (R)-3-[((-)-10-camphorsulfonyl)oxy]tetrahydrothiophene [ No CAS ]
  • (S)-3-[((-)-10-camphorsulfonyl)oxy]tetrahydrothiophene [ No CAS ]
YieldReaction ConditionsOperation in experiment
With dmap; In dichloromethane; at 5 - 20℃; General procedure: 4.2.2 (R)-3-[(Methanesulfonyl)oxy]tetrahydrothiophene 4 (R)-4 Compound (R)-1 (3.0 g, 28.8 mmol) was dissolved in CH2Cl2 (30 mL) and cooled to 5 C. To this solution were added DMAP (5.28 g, 43.2 mmol) and methanesulfonyl chloride (3.96 g, 34.6 mmol) at 5 C, and the mixture was stirred overnight at room temperature. After monitoring that the reaction was complete by TLC (hexane/EtOAc 1:1), 1 M HCl (15 mL) was added. The two layers were separated, and the aqueous layer was extracted with CH2Cl2 (2 * 10 mL). All organic layers were washed with brine, and dried (Na2SO4). The solvent was evaporated in vacuum to provide crude (R)-4. The crude was purified by silica gel chromatography (hexane/EtOAc 2:1-1:1, stepwise) to yield (R)-4 (4.59 g, 87%) as a pale yellow oil
 

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