[ CAS No. 3343-29-1 ] {[proInfo.proName]}

Name: 3343-29-1|(S)-5-Amino-2-(1,3-dioxoisoindolin-2-yl)-5-oxopentanoic acid|98%
Brand: Ambeed
SKU: A773003
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2D 3D

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Quality Control of [ 3343-29-1 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 3343-29-1 ]

SDS Specification

Alternatived Products of [ 3343-29-1 ]

Product Details of [ 3343-29-1 ]

CAS No. :	3343-29-1	MDL No. :	MFCD00190993
Formula :	C₁₃H₁₂N₂O₅	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	JMKLVQRQCLMCIN-VIFPVBQESA-N
M.W :	276.24	Pubchem ID :	259136
Synonyms :

Calculated chemistry of [ 3343-29-1 ]

Physicochemical Properties

Num. heavy atoms :	20
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.23
Num. rotatable bonds :	5
Num. H-bond acceptors :	5.0
Num. H-bond donors :	2.0
Molar Refractivity :	70.63
TPSA :	117.77 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-8.18 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.73
Log Po/w (XLOGP3) :	-0.27
Log Po/w (WLOGP) :	-0.38
Log Po/w (MLOGP) :	0.07
Log Po/w (SILICOS-IT) :	0.3
Consensus Log Po/w :	0.09

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	0.0
Bioavailability Score :	0.56

Water Solubility

Log S (ESOL) :	-1.27
Solubility :	14.7 mg/ml ; 0.0531 mol/l
Class :	Very soluble
Log S (Ali) :	-1.74
Solubility :	4.98 mg/ml ; 0.018 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-1.88
Solubility :	3.62 mg/ml ; 0.0131 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	0.0
Synthetic accessibility :	2.27

Safety of [ 3343-29-1 ]

Signal Word:	Warning	Class:
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:
Hazard Statements:	H302-H315-H319-H335	Packing Group:
GHS Pictogram:

Application In Synthesis of [ 3343-29-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 3343-29-1 ]
Downstream synthetic route of [ 3343-29-1 ]

[ 3343-29-1 ] Synthesis Path-Upstream 1~1

1
[ 3343-29-1 ]
[ 50-35-1 ]

Reference： [1] Organic Process Research and Development, 1999, vol. 3, # 2, p. 139 - 140

[ 3343-29-1 ] Synthesis Path-Downstream 1~12

1
[ 25830-77-7 ]
[ 3343-29-1 ]

Reference： [1]Journal of the Chemical Society,1949,p. 3315,3318

2
[ 3343-29-1 ]
[ 85148-77-2 ]

Reference： [1]Chemical and pharmaceutical bulletin,1982,vol. 30,p. 3831 - 3833

5
[ 841-67-8 ]
[ 2614-08-6 ]
[ 2614-06-4 ]
(S)-2-(α-carboxybenzamide)glutarimide [ No CAS ]
[ 3343-29-1 ]

Reference： [1]Chemical Research in Toxicology,1998,vol. 11,p. 1521 - 1528

6
[ 3343-29-1 ]
[ 85148-78-3 ]

Reference： [1]Chemical and pharmaceutical bulletin,1982,vol. 30,p. 3831 - 3833

7
[ 3343-29-1 ]
[ 73-22-3 ]

Reference： [1]Chemical and pharmaceutical bulletin,1982,vol. 30,p. 3831 - 3833

8
[ 85-44-9 ]
[ 56-85-9 ]
[ 3343-29-1 ]

Yield	Reaction Conditions	Operation in experiment
72%		Example 1: <n="6"/>Preparation of N-Phthaloyl-L-glutamine:To a dry three necked flask added dry dimethylformamide (DMF) (60 ml) and L- glutamine (2Og, 136mmole). Slowly heated to 40-450C. To the resulting solution added phthalicanhydride (20 g, 135mmole) and heated to 90-950C. Stirred for 3 hr at this temperature, cooled to 65 0C, and distilled DMF under vacuum. Charged DM water (120 ml). pH of the solution adjusted to 1.2 with 6N HCl. Stirred for 2 hr at 15C. Filtered, washed with DM water (40 ml). Dried to get N-phthaloyl-Lglutamine (27 g, 97.8 mmole, 72%) as a white solid, m.p., 168-170 0C.IH NMR (dmso-d6): δ 13.20 (br s, IH, COOH), 8.05-7.75 (m, 4H, Ar), 7.22 (s, IH, CONH2), 6.72 (s,lH, CONH2), 4.72 (dd, IH5CH), 2.50-1.95 (m,4H, CH2CH2), 2.15-2.00 (m, IH, CH2).13C NMR (dmso-d6): δ 173.0, 170.4, 167.3, 134.7, 131.2, 123.3, 51.2, 31.3, 23.9.
~ 52.9%		Example 1: Preparation of N-phtiialoyl-L-glutamineTo a suspension of phthalic anhydride (11.1 g or 0.076 mol) in dimethylformamide (DMF) (62 ml), L-glutamine (10 g or 0.067 mol) was added and the mixture was heated to a temperature of 90C to 95C for a period of 6 to 8 hours (or until completion of the reaction). When the reaction was complete, the excess solvent was removed by distillation at 65C to 70C under reduced pressure. The residue was cooled to a temperature of 25C to 30C and water (100 ml) was added. The solution was acidified with aqueous hydrochloric acid (50%) and stirred for a period of 8 to 10 hours. The resulting N- phthaloyl-L-glutamine was isolated by filtration, washed with water followed by methanol. The product was finally dried to a constant weight at a temperature of 55C to 60C under vacuum (80 to 100 mmHg) to produce an off-white solid.Yield: 9.5 to 11 g (-52.9% molar)
	With triethylamine; In toluene; at 110℃;Product distribution / selectivity;	L-glutamine (10Og) and phthalic anhydride (14Og) were suspended in toluene (1 liter) in a flask provided with a dean stark water separator. Triethyl amine (100 ml) was added to the flask. The contents of the flask were heated gradually to 110C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, the reaction mass was cooled to 50-60C and acetic anhydride (200 ml) was added thereto slowly. The resulting suspension was heated at 1100C, maintained for about three hours and cooled to 25-3O0C to obtain a solid. The solid was filtered and dried at 50-550C to obtain thalidomide (80 g).; L-glutamine (100g) and phthalic anhydride (135g) were suspended in toluene (1 liter) in a flask provided with a dean stark water separator. Triethyl amine (135ml) was added to the flask. The contents of the flask were heated gradually to 1100C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, the reaction mass was cooled to 50-60C and acetyl chloride (200ml) was added thereto slowly. The resulting suspension was heated at 1100C, maintained for about three hours <n="15"/>and cooled to 25-3O0C to obtain a solid. The solid was filtered and dried at 50-550C to obtain thalidomide (65g).; L-glutamine (100g) and phthalic anhydride (125g) were suspended in toluene (1 liter) in a flask provided with a dean stark water separator. Triethyl amine (100ml) was added to the flask. The contents of the flask were heated gradually to 1100C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, toluene was distilled out under vacuum. Acetic anhydride (200ml) was added thereto slowly. The reaction mass was heated at 120C and maintained for two hours. Acetic <n="17"/>anhydride was distilled out under vacuum to obtain a residue. Denatured alcohol (200ml) was added to the residue, refluxed for about half an hour and cooled to 15-200C to obtain a solid. The solid was filtered and dried under vacuum to obtain thalidomide (65g).; L-glutamine (100g) and phthalic anhydride (135g) were suspended in toluene (1 liter) in a flask provided with a dean stark water separator. Triethyl amine (100ml) was added to the flask. The contents of the flask were heated gradually to 11O0C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, toluene was distilled out under vacuum. Acetyl chloride (20OmI) was added slowly to the flask followed by N,N-dimethyl formamide (200ml). The temperature of the reaction mass was raised to 5O0C and maintained for 2 hours. Acetyl chloride was distilled out under vacuum to obtain a residue. Denatured alcohol (200ml) was added to the residue, refluxed for about half an hour and cooled to 15-200C to obtain a solid. The solid was filtered and dried under vacuum to obtain thalidomide (55g).

	With triethylamine; In chlorobenzene; at 110℃;Product distribution / selectivity;	L-glutamine (100g) and phthalic anhydride (125g) suspended in chlorobenzene (1 liter) in a flask provided with a dean stark water separator followed by triethyl amine (135ml). The contents of the flask were heated gradually to 11O0C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, the reaction mass was cooled to 50-600C and acetic anhydride (200ml) was added thereto slowly. The resulting suspension was heated to 1100C, maintained for about three hours and cooled to 25-3O0C to obtain a solid. The solid was filtered and dried at 50-550C to obtain thalidomide (72g).
	With triethylamine; In xylene; at 140℃;Product distribution / selectivity;	L-glutamine (100g) and phthalic anhydride (14Og) were suspended in xylene (1 liter) in a flask provided with a dean stark water separator followed by triethyl amine (130ml). The contents of the flask were heated gradually to 1400C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, the reaction mass was cooled to 50-600C and acetic anhydride (200ml) was added thereto slowly. The resulting suspension was heated at 1100C, maintained for about three hours and cooled to 25-3O0C to obtain a solid. The solid was filtered and dried at 50-550C to obtain thalidomide (73g).

Reference： [1]Patent: WO2008/35378,2008,A2 .Location in patent: Page/Page column 5
[2]Patent: WO2011/154739,2011,A1 .Location in patent: Page/Page column 24-25
[3]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 12-15
[4]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 14
[5]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 13

9
[ 3343-29-1 ]
[ 841-67-8 ]

Yield	Reaction Conditions	Operation in experiment
91%	With 1,1'-carbonyldiimidazole;dmap; In acetonitrile; for 5 - 6h;Heating / reflux;	Example 3:Preparation of Thalidomide: (using CDI in acetonitrile)A stirred mixture of N-phthaloyl-L-glutamine (20 g, 72.4 mmole), l,l'-Carbonyl-di- imidazole (15.85 g, 97.7 mmole) and 4-dimethylamino-pyridine (40 mg, 0.32 mmole) in acetonitrile (60 ml)was heated to reflux for 5-6 hr. The reaction slurry was filtered and the solid was washed with acetonitrile (20 ml). The crude solid was slurried in methanol (40 ml), filtered and washed with fresh methanol (20 ml). The solid was air dried and then dried in vacuum at 60 0C to afford 17.1 g (91%) of Thalidomide as a white powder, m.p. 212-21 A 0C.IH NMR (dmso-d6): δ 1 1.13 (s, IH, NH), 7.95-7.80 (br, s, 4H, Ar), 5.17 (dd, IH, CHCO), 2.92-2.84 (m, IH, CH2CO), 2.64-2.50(m, 2H, CH2CH2), 2.10-2.07 (m, IH, CH2).13C NMR (dmso-d6): δ 172.8, 169.18, 134.9, 131.2, 123.4, 49.0, 30.9, 22.0.
81.3%	With 1,1'-Carbonyl-di-(1,2,4-triazole);dmap; In ethyl acetate; for 4h;Heating / reflux;	Example 2:Preparation of Thalidomide: (using CDT as cyclising reagent)To a dry three necked flask added ethylacetate (30 ml) and N-phthaloyl-L-glutamine (5 g, 18.1 mmole). The slurry was stirred and added l,r-carbonyldi(l,2,4-triazole) (3,95 g, 24 mmole) followed by 4-dimethylamino- pyridine ( 10 mg, 0.08 mmole) as catalyst. The resulting solution was heated to reflux for 4 hr. The reaction mixture was cooled to 25-27C, filtered and the solid was washed with ethylacetate (8 ml). The solid slurried in methanol (15 ml), stirred for 15 min., filtered and washed with methanol (8 ml). Dried the product under vacuum at 60 0C for 5 hr to afford 3.8 g (81.3%) of Thalidomide as a white powder, m.p. 273-275 0C.IH NMR (dmso-d6): δ 1 1.13 (s, IH, NH), 7.95-7.80 (br, s, 4H, Ar), 5.18 (dd, IH, CHCO), 2.96-2, 85 (m, IH, CH2CO), 2.63-2.50 (m, 2H, CH2CH2), 2.09-2.05(m, IH, CH2).13C NMR (dmso-d6): δ 172.8, 169.18, 134.9, 131.2, 123.4, 49.0, 30.9, 22.0.
~ 70%	With dmap; 1,1'-carbonyldiimidazole; In acetonitrile; at 75 - 77℃;Product distribution / selectivity;	Example 2: Preparation of thalidomide (oc-form)To a suspension of N-phthaloyl-L-glutamine (10 g or 0.036 mol) in acetonitrile (100 ml), carbonyl-diimidazole (7.65 g or 0.047 mol) and 4-dimemylaminopyridine (0.016 g or 1.3x10"3 mol) were added and the reaction mixture heated to a temperature of 75C to 77C and held at that temperature for a period of 6 to 8 hours (or until completion of the reaction). The reaction mixture was then allowed to cool to a temperature of 25C to 30C. The solid product was then isolated by filtration and washed with methanol. Finally the product was dried to a constant weight under vacuum (~100 mmHg) at a temperature of 50C to 55C to give the oc-form of thalidomide as a white to off-white solid.Yield: 6.5 to 7.0 g (-70% molar)Melting Range: 271C to 274CHPLC purity: 99.89% (by area normalization)Polymorphic purity (as measured by XRPD): > 99.5%DSC: Single peak at 274C

	With acetic anhydride; In toluene; at 50 - 110℃; for 3h;Product distribution / selectivity;	L-glutamine (10Og) and phthalic anhydride (14Og) were suspended in toluene (1 liter) in a flask provided with a dean stark water separator. Triethyl amine (100 ml) was added to the flask. The contents of the flask were heated gradually to 110C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, the reaction mass was cooled to 50-60C and acetic anhydride (200 ml) was added thereto slowly. The resulting suspension was heated at 1100C, maintained for about three hours and cooled to 25-3O0C to obtain a solid. The solid was filtered and dried at 50-550C to obtain thalidomide (80 g).
	With acetic anhydride; In chlorobenzene; at 50 - 110℃; for 3h;Product distribution / selectivity;	L-glutamine (100g) and phthalic anhydride (125g) suspended in chlorobenzene (1 liter) in a flask provided with a dean stark water separator followed by triethyl amine (135ml). The contents of the flask were heated gradually to 11O0C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, the reaction mass was cooled to 50-600C and acetic anhydride (200ml) was added thereto slowly. The resulting suspension was heated to 1100C, maintained for about three hours and cooled to 25-3O0C to obtain a solid. The solid was filtered and dried at 50-550C to obtain thalidomide (72g).
	With acetic anhydride; In xylene; at 50 - 110℃; for 3h;Product distribution / selectivity;	L-glutamine (100g) and phthalic anhydride (14Og) were suspended in xylene (1 liter) in a flask provided with a dean stark water separator followed by triethyl amine (130ml). The contents of the flask were heated gradually to 1400C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, the reaction mass was cooled to 50-600C and acetic anhydride (200ml) was added thereto slowly. The resulting suspension was heated at 1100C, maintained for about three hours and cooled to 25-3O0C to obtain a solid. The solid was filtered and dried at 50-550C to obtain thalidomide (73g).
	With acetic anhydride; at 120℃; for 2h;Product distribution / selectivity;	L-glutamine (100g) and phthalic anhydride (125g) were suspended in toluene (1 liter) in a flask provided with a dean stark water separator. Triethyl amine (100ml) was added to the flask. The contents of the flask were heated gradually to 1100C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, toluene was distilled out under vacuum. Acetic anhydride (200ml) was added thereto slowly. The reaction mass was heated at 120C and maintained for two hours. Acetic <n="17"/>anhydride was distilled out under vacuum to obtain a residue. Denatured alcohol (200ml) was added to the residue, refluxed for about half an hour and cooled to 15-200C to obtain a solid. The solid was filtered and dried under vacuum to obtain thalidomide (65g).
	With acetyl chloride; In N,N-dimethyl-formamide; at 50℃; for 2h;Product distribution / selectivity;	L-glutamine (100g) and phthalic anhydride (135g) were suspended in toluene (1 liter) in a flask provided with a dean stark water separator. Triethyl amine (100ml) was added to the flask. The contents of the flask were heated gradually to 11O0C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, toluene was distilled out under vacuum. Acetyl chloride (20OmI) was added slowly to the flask followed by N,N-dimethyl formamide (200ml). The temperature of the reaction mass was raised to 5O0C and maintained for 2 hours. Acetyl chloride was distilled out under vacuum to obtain a residue. Denatured alcohol (200ml) was added to the residue, refluxed for about half an hour and cooled to 15-200C to obtain a solid. The solid was filtered and dried under vacuum to obtain thalidomide (55g).
	With acetyl chloride; In toluene; at 50 - 110℃; for 3h;Product distribution / selectivity;	L-glutamine (100g) and phthalic anhydride (135g) were suspended in toluene (1 liter) in a flask provided with a dean stark water separator. Triethyl amine (135ml) was added to the flask. The contents of the flask were heated gradually to 1100C. The water generated during the course of reaction was separated azeotropically. After completion of reaction, the reaction mass was cooled to 50-60C and acetyl chloride (200ml) was added thereto slowly. The resulting suspension was heated at 1100C, maintained for about three hours <n="15"/>and cooled to 25-3O0C to obtain a solid. The solid was filtered and dried at 50-550C to obtain thalidomide (65g).

Reference： [1]Patent: WO2008/35378,2008,A2 .Location in patent: Page/Page column 6
[2]Patent: WO2008/35378,2008,A2 .Location in patent: Page/Page column 5
[3]Patent: WO2011/154739,2011,A1 .Location in patent: Page/Page column 25
[4]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 12
[5]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 14
[6]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 13
[7]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 14-15
[8]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 15
[9]Patent: WO2009/83724,2009,A1 .Location in patent: Page/Page column 12-13

10
[ 56-85-9 ]
[ 22509-74-6 ]
[ 3343-29-1 ]

Reference： [1]Organic Process Research and Development,1999,vol. 3,p. 139 - 140

11
[ 3343-29-1 ]
[ 50-35-1 ]

Reference： [1]Organic Process Research and Development,1999,vol. 3,p. 139 - 140

12
[ 841-67-8 ]
[ 2614-08-6 ]
(S)-2-(α-carboxybenzamide)glutarimide [ No CAS ]
[ 3343-29-1 ]

Reference： [1]Chirality,2017,vol. 29,p. 282 - 293

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Ghs Precautionary Statements

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P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 3343-29-1 ] {[proInfo.proName]}

Quality Control of [ 3343-29-1 ]

Related Doc. of [ 3343-29-1 ]

Product Details of [ 3343-29-1 ]

Calculated chemistry of [ 3343-29-1 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 3343-29-1 ]

Application In Synthesis of [ 3343-29-1 ]

[ 3343-29-1 ] Synthesis Path-Upstream 1~1

[ 3343-29-1 ] Synthesis Path-Downstream 1~12

Related Functional Groups of [ 3343-29-1 ]

Amides

Amines

Carboxylic Acids

Related Parent Nucleus of [ 3343-29-1 ]

Indolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

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[ 3343-29-1 ]

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[ 3343-29-1 ]